2026 ICD-10-CM Diagnosis Code R53.1Weakness

AHRQ’s CCSR groups this code into broader clinical categories.

• Asthenia

  clinical sign or symptom manifested as debility, or lack or loss of strength and energy.

• Neurocirculatory Asthenia

  a clinical syndrome characterized by palpitation, shortness of breath, labored breathing, subjective complaints of effort and discomfort, all following slight physical exertion. other symptoms may be dizziness, tremulousness, sweating, and insomnia. neurocirculatory asthenia is most typically seen as a form of anxiety disorder.

• Bilateral Vestibular Weakness|Bilateral loss of labyrinthine reactivity

  a reduction or absence of vestibular function occurring in both inner ears.

• EORTC QLQ-CLL17 - Muscle Weakness|EOR29-Muscle Weakness|EOR29-Muscle Weakness|EOR2931

  european organization for the research and treatment of cancer quality of life questionnaire - chronic lymphocytic leukemia 17 items (eortc qlq-cll17) have you had muscle weakness?

• Feel Weakness in Arm or Hand Question|Does your arm or hand feel weak|Feel Weakness in Arm or Hand

  a question about whether an individual has or had weakness in their arm or hand.

• Grade 1 Facial Muscle Weakness, CTCAE|Grade 1 Facial muscle weakness

  mild symptoms; clinical or diagnostic observations only; intervention not indicated

• Grade 2 Facial Muscle Weakness, CTCAE|Grade 2 Facial muscle weakness

  moderate symptoms; limiting instrumental adl or mild/moderate impact on age-appropriate normal daily activity (pediatric)

• Grade 2 Generalized Muscle Weakness, CTCAE|Grade 2 Generalized muscle weakness

  symptomatic; evident on physical exam; limiting instrumental adl or mild/moderate impact on age-appropriate normal daily activity (pediatric)

• Grade 2 Muscle Weakness Lower Limb, CTCAE|Grade 2 Muscle weakness lower limb

  symptomatic; evident on physical exam; limiting instrumental adl or mild/moderate impact on age-appropriate normal daily activity (pediatric)

• Grade 2 Muscle Weakness Trunk, CTCAE|Grade 2 Muscle weakness trunk

  symptomatic; evident on physical exam; limiting instrumental adl or mild/moderate impact on age-appropriate normal daily activity (pediatric)

• Grade 2 Muscle Weakness Upper Limb, CTCAE|Grade 2 Muscle weakness upper limb

  symptomatic; evident on physical exam; limiting instrumental adl or mild/moderate impact on age-appropriate normal daily activity (pediatric)

• Grade 2 Pelvic Floor Muscle Weakness, CTCAE|Grade 2 Pelvic floor muscle weakness

  symptomatic, not interfering with bladder, bowel, or vaginal function; limiting instrumental adl or mild/moderate impact on age-appropriate normal daily activity (pediatric)

• Grade 3 Facial Muscle Weakness, CTCAE|Grade 3 Facial muscle weakness

  severe symptoms; limiting self-care adl or severe impact on age-appropriate normal daily activity (pediatric)

• Grade 3 Generalized Muscle Weakness, CTCAE|Grade 3 Generalized muscle weakness

  limiting self-care adl or severe impact on age-appropriate normal daily activity (pediatric)

• Grade 3 Muscle Weakness Lower Limb, CTCAE|Grade 3 Muscle weakness lower limb

  limiting self-care adl or severe impact on age-appropriate normal daily activity (pediatric)

• Grade 3 Muscle Weakness Trunk, CTCAE|Grade 3 Muscle weakness trunk

  limiting self-care adl or severe impact on age-appropriate normal daily activity (pediatric)

• Grade 3 Muscle Weakness Upper Limb, CTCAE|Grade 3 Muscle weakness upper limb

  limiting self-care adl or severe impact on age-appropriate normal daily activity (pediatric)

• Grade 3 Pelvic Floor Muscle Weakness, CTCAE|Grade 3 Pelvic floor muscle weakness

  severe symptoms; limiting self-care adl or severe impact on age-appropriate normal daily activity (pediatric)

• Have Difficulty Climbing Stairs or Getting Out of Chair Because of Weakness in Legs Question|Did you have difficulty climbing stairs or getting up out of a chair because of weakness in your legs|Have Difficulty Climbing Stairs or Getting Out of Chair Because of Weakness in Legs

  a question about whether an individual has or had difficulty climbing stairs or getting up out of a chair because of weakness in their legs.

• Have Difficulty Opening a Jar or Bottle Because of Weakness in Hands Question|Did you have difficulty opening a jar or bottle because of weakness in your hands|Have Difficulty Opening a Jar or Bottle Because of Weakness in Hands

  a question about whether an individual has or had difficulty opening a jar or bottle because of weakness in their hands.

• Have Felt Unusual Weakness Question|Have Felt Unusual Weakness|Have Felt Unusual Weakness

  a question about whether an individual feels or felt unusual weakness.

• Have Weakness in Legs Question|Have Leg Weakness|Have Weakness in Legs|I have weakness in my legs|My legs feel weak

  a question about whether an individual has or had weakness in their legs.

• Have Weakness in Limbs Question|Did you feel weak in your arms and legs|Feel Weak in Arms and Legs|Have Weakness in Limbs|I have weakness in my arms or legs

  a question about whether an individual has or had weakness in their arms or legs.

• Have Weakness of Both Legs Question|Did you have weakness of both legs|Have Weakness of Both Legs

  a question about whether an individual has or had weakness of both legs.

• Have Weakness on One Side of Body Question|Did you have weakness on one side of your body|Have Weakness on One Side of Body

  a question about whether an individual has or had weakness on one side of the body.

• How Much Bothered by Arm Weakness in Affected Arm Question|Arm weakness|How Much Bothered by Arm Weakness in Affected Arm

  a question about how bothered an individual is by arm weakness in their affected arm.

• How Often Experienced Difficulty Doing Everyday Activities Because of Abdominal Muscle Weakness Question|Difficulty doing everyday activities because of abdominal muscle weakness (e.g. making your bed)|How Often Experienced Difficulty Doing Everyday Activities Because of Abdominal Muscle Weakness

  a question about how often an individual has or had experienced difficulty doing everyday activities because of abdominal muscle weakness (e.g.making their bed).

• How Often Experienced Difficulty Sitting up Because Abdominal Muscle Weakness Question|Difficulty sitting up because of abdominal muscle weakness (e.g. getting out of bed)|How Often Experienced Difficulty Sitting up Because Abdominal Muscle Weakness

  a question about how often an individual has or had experienced difficulty sitting up because of abdominal muscle weakness (e.g.getting out of bed).

• Weakness in Arms and/or Legs at its Worst Question|Weakness in Arms and/or Legs at its Worst|Your weakness in the arms and/or legs at its worst

  a question about an individual's weakness in their arms and/or legs at its worst.

• Weakness on One Side of the Body at its Worst Question|Weakness on One Side of the Body at its Worst|Weakness on one side of the body at its worst

  a question about an individual's weakness on one side of the body at its worst.

• Eye Muscle Weakness

  a reduction in the strength of the eye muscles.

• Facial Muscle Weakness, CTCAE|Facial Muscle Weakness|Facial muscle weakness

  a disorder characterized by a reduction in the strength of the facial muscles.

• Facial Muscle Weakness|Facial muscle weakness

  a reduction in the strength of the facial muscles.

• Facial Weakness following Cerebral Infarction|Facial weakness following cerebral infarction

  evidence of facial weakness following cerebral infarction.

• Facial Weakness following Other Cerebrovascular Disease|Facial weakness following other cerebrovascular disease

  evidence of facial weakness following other cerebrovascular disease.

• Facial Weakness following Unspecified Cerebrovascular Disease|Facial weakness following unspecified cerebrovascular disease

  evidence of facial weakness following unspecified cerebrovascular disease.

• FACIT-Searchable Item Library Adult Version - Have Weakness in My Arms or Legs|FSIL-Have Weakness in My Arms or Legs|FSIL-Have Weakness in My Arms or Legs|FSIL0100

  functional assessment of chronic illness therapy-searchable item library adult version (facit-searchable item library adult version) i have weakness in my arms or legs.

• FACIT-Searchable Item Library Adult Version - I Have Weakness in My Legs|FSIL-I Have Weakness in My Legs|FSIL-I Have Weakness in My Legs|FSIL0495

  functional assessment of chronic illness therapy-searchable item library adult version (facit-searchable item library adult version) i have weakness in my legs.

• FBRSI - Have Weakness in My Arms or Legs|FAC029-Have Weakness in My Arms or Legs|FAC029-Have Weakness in My Arms or Legs|FAC02903

  functional assessment of cancer therapy-brain symptom index (fbrsi) i have weakness in my arms or legs.

• Feel Weakness in Arm or Hand|Does your arm or hand feel weak

  a question about whether an individual has or had weakness in their arm or hand.

• Focal Motor Weakness|Focal motor weakness

  impairments of brain function, the nerve or spinal cord that affect a specific region of the body.

• Generalized Muscle Weakness, CTCAE|Generalized Muscle Weakness|Generalized muscle weakness

  a disorder characterized by a reduction in the strength of muscles in multiple anatomic sites.

• Generalized Muscle Weakness|Generalized muscle weakness

  a reduction in the strength of muscles in multiple anatomic sites.

• Grade 1 Facial Muscle Weakness, CTCAE|Grade 1 Facial muscle weakness

  asymptomatic; clinical or diagnostic observations only; intervention not indicated

• Grade 1 Generalized Muscle Weakness, CTCAE|Grade 1 Generalized muscle weakness

  symptomatic; perceived by patient but not evident on physical exam

• Grade 1 Muscle Weakness Left-Sided, CTCAE|Grade 1 Muscle weakness left-sided

  symptomatic; perceived by patient but not evident on physical exam

• Grade 1 Muscle Weakness Lower Limb, CTCAE|Grade 1 Muscle weakness lower limb

  symptomatic; perceived by patient but not evident on physical exam

• Grade 1 Muscle Weakness Right-Sided, CTCAE|Grade 1 Muscle weakness right-sided

  symptomatic; perceived by patient but not evident on physical exam

• Grade 1 Muscle Weakness Trunk, CTCAE|Grade 1 Muscle weakness trunk

  symptomatic; perceived by patient but not evident on physical exam

• Grade 1 Muscle Weakness Upper Limb, CTCAE|Grade 1 Muscle weakness upper limb

  symptomatic; perceived by patient but not evident on physical exam

• Grade 1 Pelvic Floor Muscle Weakness, CTCAE|Grade 1 Pelvic floor muscle weakness

  asymptomatic; clinical or diagnostic observations only; intervention not indicated

• Grade 2 Facial Muscle Weakness, CTCAE|Grade 2 Facial muscle weakness

  moderate symptoms; limiting instrumental adl

• Grade 2 Generalized Muscle Weakness, CTCAE|Grade 2 Generalized muscle weakness

  symptomatic; evident on physical exam; limiting instrumental adl

• Grade 2 Muscle Weakness Left-Sided, CTCAE|Grade 2 Muscle weakness left-sided

  symptomatic; evident on physical exam; limiting instrumental adl

• Grade 2 Muscle Weakness Lower Limb, CTCAE|Grade 2 Muscle weakness lower limb

  symptomatic; evident on physical exam; limiting instrumental adl

• Grade 2 Muscle Weakness Right-Sided, CTCAE|Grade 2 Muscle weakness right-sided

  symptomatic; evident on physical exam; limiting instrumental adl

• Grade 2 Muscle Weakness Trunk, CTCAE|Grade 2 Muscle weakness trunk

  symptomatic; evident on physical exam; limiting instrumental adl

• Grade 2 Muscle Weakness Upper Limb, CTCAE|Grade 2 Muscle weakness upper limb

  symptomatic; evident on physical exam; limiting instrumental adl

• Grade 2 Pelvic Floor Muscle Weakness, CTCAE|Grade 2 Pelvic floor muscle weakness

  symptomatic, not interfering with bladder, bowel, or vaginal function; limiting instrumental adl

• Grade 3 Facial Muscle Weakness, CTCAE|Grade 3 Facial muscle weakness

  severe symptoms; limiting self care adl

• Grade 3 Generalized Muscle Weakness, CTCAE|Grade 3 Generalized muscle weakness

  limiting self care adl

• Grade 3 Muscle Weakness Left-Sided, CTCAE|Grade 3 Muscle weakness left-sided

  limiting self care adl

• Grade 3 Muscle Weakness Lower Limb, CTCAE|Grade 3 Muscle weakness lower limb

  limiting self care adl

• Grade 3 Muscle Weakness Right-Sided, CTCAE|Grade 3 Muscle weakness right-sided

  limiting self care adl

• Grade 3 Muscle Weakness Trunk, CTCAE|Grade 3 Muscle weakness trunk

  limiting self care adl

• Grade 3 Muscle Weakness Upper Limb, CTCAE|Grade 3 Muscle weakness upper limb

  limiting self care adl

• Grade 3 Pelvic Floor Muscle Weakness, CTCAE|Grade 3 Pelvic floor muscle weakness

  severe symptoms; limiting self care adl

• Have Difficulty Climbing Stairs or Getting Out of Chair Because of Weakness in Legs|Did you have difficulty climbing stairs or getting up out of a chair because of weakness in your legs

  a question about whether an individual has or had difficulty climbing stairs or getting up out of a chair because of weakness in their legs.

• Have Difficulty Opening a Jar or Bottle Because of Weakness in Hands|Did you have difficulty opening a jar or bottle because of weakness in your hands

  a question about whether an individual has or had difficulty opening a jar or bottle because of weakness in their hands.

• Have Felt Unusual Weakness

  a question about whether an individual feels or felt unusual weakness.

• Have Weakness in Legs|Have Leg Weakness|I have weakness in my legs|My legs feel weak

  a question about whether an individual has or had weakness in their legs.

• Have Weakness in Limbs|Did you feel weak in your arms and legs|Feel Weak in Arms and Legs|I have weakness in my arms or legs

  a question about whether an individual has or had weakness in their arms or legs.

• Have Weakness of Both Legs|Did you have weakness of both legs

  a question about whether an individual has or had weakness of both legs.

• Have Weakness on One Side of Body|Did you have weakness on one side of your body

  a question about whether an individual has or had weakness on one side of the body.

• How Much Bothered by Arm Weakness in Affected Arm|Arm weakness

  a question about how bothered an individual is by arm weakness in their affected arm.

• How Often Experienced Difficulty Doing Everyday Activities Because of Abdominal Muscle Weakness|Difficulty doing everyday activities because of abdominal muscle weakness (e.g. making your bed)

  a question about how often an individual has or had experienced difficulty doing everyday activities because of abdominal muscle weakness (e.g.making their bed).

• How Often Experienced Difficulty Sitting up Because Abdominal Muscle Weakness|Difficulty sitting up because of abdominal muscle weakness (e.g. getting out of bed)

  a question about how often an individual has or had experienced difficulty sitting up because of abdominal muscle weakness (e.g.getting out of bed).

• KFSS - Weakness Interferes With Testing|KFSS1-Weakness Interferes With Testing|KFSS1-Weakness Interferes With Testing|KFSS102A

  kurtzke functional systems scores (kfss) record number 1 in small box when weakness (grade 3 or worse on pyramidal) interferes with testing.

• Kurtzke Functional System Scores KFSS103 Original Result - Severe nystagmus, marked extraocular weakness, or moderate disability of other cranial nerves|KFSS103-Severe nystagmus, marked extraocular weakness, or moderate disability of other cranial nerves|Severe nystagmus, marked extraocular weakness, or moderate disability of other cranial nerves

  kurtzke functional system scores kfss103 original result - severe nystagmus, marked extraocular weakness, or moderate disability of other cranial nerves.

• Muscle Weakness

  a reduction in the strength of one or more muscles.

• Muscle Weakness Left-Sided, CTCAE|Muscle Weakness Left-Sided|Muscle weakness left-sided

  a disorder characterized by a reduction in the strength of the muscles on the left side of the body.

• Muscle Weakness Left-Sided|Muscle weakness left-sided

  a reduction in the strength of the muscles in the left side of the body.

• Muscle Weakness Lower Limb, CTCAE|Muscle Weakness Lower Limb|Muscle weakness lower limb

  a disorder characterized by a reduction in the strength of the lower limb muscles.

• Muscle Weakness Lower Limb|Muscle weakness lower limb

  a reduction in the strength of the lower limb muscles.

• Muscle Weakness Right-Sided, CTCAE|Muscle Weakness Right-Sided|Muscle weakness right-sided

  a disorder characterized by a reduction in the strength of the muscles on the right side of the body.

• Muscle Weakness Right-Sided|Muscle weakness right-sided

  a reduction in the strength of the muscles in the right side of the body.

• Muscle Weakness Trunk, CTCAE|Muscle Weakness Trunk|Muscle weakness trunk

  a disorder characterized by a reduction in the strength of the trunk muscles.

• Muscle Weakness Trunk|Muscle weakness trunk

  a reduction in the strength of the trunk muscles.

• Muscle Weakness Upper Limb, CTCAE|Muscle Weakness Upper Limb|Muscle weakness upper limb

  a disorder characterized by a reduction in the strength of the upper limb muscles.

• Muscle Weakness Upper Limb|Muscle weakness upper limb

  a reduction in the strength of the upper limb muscles.

• Muscle Weakness/Atrophy

  a reduction in the strength and/or mass of one or more muscles.

• NCCN-FACT FBRSI-24 Version 2 - Have Weakness in My Arms or Legs|FAC030-Have Weakness in My Arms or Legs|FAC030-Have Weakness in My Arms or Legs|FAC03005

  national comprehensive cancer network/functional assessment of cancer therapy-brain symptom index-24 version 2 (nccn-fact fbrsi-24 version 2) i have weakness in my arms or legs.

• NCCN-FACT-FPSI 17 Version 2 - I Have Weakness in My Legs|FAC052-I Have Weakness in My Legs|FAC052-I Have Weakness in My Legs|FAC05207

  national comprehensive cancer network/functional assessment of cancer therapy-prostate symptom index 17 version 2 (nccn-fact-fpsi 17 version 2) i have weakness in my legs.

• Pain or Weakness in Shoulder has Caused Work Change|Pain or weakness in my shoulder has caused me to change my work

  a response indicating that an individual has or had shoulder pain or weakness that has caused a work change.

• Pelvic Floor Muscle Weakness, CTCAE|Pelvic Floor Muscle Weakness|Pelvic floor muscle weakness

  a disorder characterized by a reduction in the strength of the muscles of the pelvic floor.

• Pelvic Floor Muscle Weakness|Pelvic floor muscle weakness

  a reduction in the strength of the muscles of the pelvic floor.

• Weakness

  the property of lacking physical strength.

• Weakness in Arms and/or Legs at its Worst|Your weakness in the arms and/or legs at its worst

  a question about an individual's weakness in their arms and/or legs at its worst.

• Weakness on One Side of the Body at its Worst|Weakness on one side of the body at its worst

  a question about an individual's weakness on one side of the body at its worst.

• Early-Onset Progressive Encephalopathy with Brain Atrophy and Thin Corpus Callosum|Early-Onset Progressive Diffuse Brain Atrophy-Microcephaly-Muscle Weakness-Optic Atrophy Syndrome|PEBAT

  an autosomal recessive condition caused by mutation(s) in the tbcd gene, encoding tubulin-specific chaperone d. it is characterized by encephalopathy, cerebellar and cerebral atrophy, and a thin corpus callosum.

• MT-ATP6 wt Allele|ATP Synthase 6 Gene|ATP6|ATPASE-6|ATPase-6|ATPase6|Complex V, ATP Synthase, Subunit ATPase6 Gene|MTATP6|Mitochondrially Encoded ATP Synthase Gene|Mitochondrially Encoded ATP Synthase Membrane Subunit 6 wt Allele|Mitochondrially Encoded ATP Synthase Membrane Subunit A Gene|Spicular Retinitis Pigmentosa with Dementia, Seizures, Ataxia, Proximal Muscle Weakness and Sensory Deficit Gene|Su6m

  human mt-atp6 wild-type allele is located within the circular mitochondrial (mt) chromosome and is approximately 681 bases in length. this allele, which encodes atp synthase subunit a protein, plays a role in proton-transport and atp synthesis. mutation of the gene is associated with neuropathy, ataxia, and retinitis pigmentosa (narp); leber hereditary optic neuropathy (lhon); leigh syndrome (ls); mitochondrial infantile bilateral striatal necrosis (mibsn); myopathy, lactic acidosis, and sideroblastic anemia 3 (mlasa3); adult-onset ataxia and polyneuropathy (apao); infantile hypertrophic cardiomyopathy (cmhi); and mitochondrial complex v (atp synthase) deficiency mitochondrial type 1 (mc5dm1).

• Muscle Weakness, Ped-PRO-CTCAE|Muscle weakness|Ped-PRO-CTCAE, Muscle Weakness

  weakness of muscles as recorded on the ped-pro-ctcae questionnaire.

Muscle Disorders

Your muscles help you move and help your body work. Different types of muscles have different jobs. There are many problems that can affect muscles. Muscle disorders can cause weakness, pain or even paralysis.

Read the full article at MedlinePlus

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