2027 ICD-10-CM Diagnosis Code N48.33Priapism, drug-induced

ICD-10-CM Codes›N00–N99›N40-N53›N48

ICD-10-CM N48.33
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

N48.33 is a billable ICD-10-CM diagnosis code for priapism, drug-induced. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 729 through 730. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 31 closely related codes. Coders also document this condition as priapism. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Drug induced or toxic related condition and Other specified male genital disorders.

Code Identity

ICD-10-CM Code
N48.33
Billable Status
Yes — Valid for Submission
Code Describes
Priapism, drug-induced
Short Description
Priapism, drug-induced
Same as the full description in the CMS dataset.
Parent Code
N48.3
Priapism

Code Classification

ChapterN00–N99Diseases of the genitourinary system
SectionN40-N53Diseases of male genital organs
CategoryN48Other disorders of penis
This CodeN48.33Priapism, drug-induced

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Priapism
  • Priapism caused by drug

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to N48.33: its own notes plus those printed at N48.3 and Chapter 14. A note printed at a category, block or chapter applies to every code under it.

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Chapter 14 (N00-N99) Diseases of the genitourinary system applies to 838 codes
  • certain conditions originating in the perinatal period (P04-P96)
  • certain infectious and parasitic diseases (A00-B99)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Code First

The underlying condition named in the note is sequenced before this code.

From N48.3 Priapism applies to 5 codes
  • underlying cause

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name N48.33, its category, or a range that includes it.

Excludes2 1

These codes carry an Excludes2 note naming N48.33: its condition is not part of those codes, and both may be reported when the patient has both.

  • Block R10-R19 Symptoms and signs involving the digestive system and abdomen
    symptoms referable to male genital organs (N48-N50) names N48-N50, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ030
Drug induced or toxic related condition
Default principal diagnosis: inpatient Yes · outpatient Yes
CCSR GEN016
Other specified male genital disorders
Default principal diagnosis: inpatient No · outpatient No

Clinical InformationClinical

  • Priapism

    a prolonged painful erection that may lasts hours and is not associated with sexual activity. it is seen in patients with sickle cell anemia, advanced malignancy, spinal trauma; and certain drug treatments.

Patient EducationClinical

Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

The full article covers:

  • What is a drug interaction?
  • What are side effects?
  • What are drug allergies?
  • How can I stay safe when taking medicines?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert N48.33 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
607.3 Priapism
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About N48.33Overview

What is the ICD-10 code for priapism, drug-induced?

The ICD-10-CM code for priapism, drug-induced is N48.33 (sometimes written as N4833). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is N48.33 (Priapism) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report priapism, drug-induced on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does N48.33 group to?

When priapism, drug-induced is the principal diagnosis on an inpatient stay, it groups to MS-DRG 729, 730, with relative weights from 0.6595 to 1.0553 depending on complications. Higher weights mean higher Medicare reimbursement.

Is N48.33 a CC or MCC?

CMS lists N48.33 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 31 closely related codes in its exclusion list.

What is coded first with N48.33?

The Code First note at N48.3, which applies to N48.33, reads: underlying cause. When one of these applies, it is sequenced before N48.33.