2026 ICD-10-CM Diagnosis Code H47.299Other optic atrophy, unspecified eye

AHRQ’s CCSR groups this code into broader clinical categories.

• Optic Atrophies, Hereditary

  hereditary conditions that feature progressive visual loss in association with optic atrophy. relatively common forms include autosomal dominant optic atrophy (optic atrophy, autosomal dominant) and leber hereditary optic atrophy (optic atrophy, hereditary, leber).

• Optic Atrophy

  atrophy of the optic disk which may be congenital or acquired. this condition indicates a deficiency in the number of nerve fibers which arise in the retina and converge to form the optic disk; optic nerve; optic chiasm; and optic tracts. glaucoma; ischemia; inflammation, a chronic elevation of intracranial pressure, toxins, optic nerve compression, and inherited conditions (see optic atrophies, hereditary) are relatively common causes of this condition.

• Optic Atrophy, Autosomal Dominant

  dominant optic atrophy is a hereditary optic neuropathy causing decreased visual acuity, color vision deficits, a centrocecal scotoma, and optic nerve pallor (hum. genet. 1998; 102: 79-86). mutations leading to this condition have been mapped to the opa1 gene at chromosome 3q28-q29. opa1 codes for a dynamin-related gtpase that localizes to mitochondria.

• Optic Atrophy, Hereditary, Leber

  a maternally linked genetic disorder that presents in mid-life as acute or subacute central vision loss leading to central scotoma and blindness. the disease has been associated with missense mutations in the mtdna, in genes for complex i, iii, and iv polypeptides, that can act autonomously or in association with each other to cause the disease. (from online mendelian inheritance in man, http://www.ncbi.nlm.nih.gov/omim/, mim#535000 (april 17, 2001))

• Autosomal Dominant Optic Atrophy

  an autosomal dominant hereditary condition characterized by optic atrophy and progressive visual loss.

• Dynamin-Like 120 kDa Protein, Mitochondrial|Dynamin-Like Guanosine Triphosphatase|EC 3.6.5.5|Mitochondrial Dynamin-Like GTPase|OPA1|OPA1 Mitochondrial Dynamin Like GTPase|OPA1 Mitochondrial Dynamin-Like GTPase|Optic Atrophy Protein 1

  dynamin-like 120 kda protein, mitochondrial (960 aa, ~112 kda) is encoded by the human opa1 gene. this protein plays a role in gtpase activity that regulates fusion and fission of mitochondria.

• Hereditary Optic Atrophy

  a family of inherited disorders characterized by progressive loss of vision secondary to death of the retinal ganglion cell axons that comprise the optic nerve.

• Leber Hereditary Optic Atrophy

  a hereditary disorder caused by mitochondrial mutations, resulting in the degeneration of the retinal ganglion cells and optic atrophy. it is characterized by an acute or subacute loss of central vision. it may initially affect one eye only, but eventually the central loss of vision becomes bilateral.

• OPA1 wt Allele|BERHS|FLJ12460|KIAA0567|MGM1|MTDPS14|NPG|NTG|OPA1 Mitochondrial Dynamin Like GTPase wt Allele|OPA1 Mitochondrial Dynamin-Like GTPase Gene|OPA1, Mitochondrial Dynamin Like GTPase Gene|Optic Atrophy 1 (Autosomal Dominant) Gene|largeG

  human opa1 wild-type allele is located in the vicinity of 3q29 and is approximately 105 kb in length. this allele, which encodes dynamin-like 120 kda protein, mitochondrial, is involved in the regulation of fusion and fission of mitochondria. mutations in this gene are associated with optic atrophy type 1, mitochondrial dna depletion syndrome 14 and behr syndrome.

• Optic Atrophy

  a disorder characterized by loss of optic nerve fibers. it may be inherited or acquired. acquired causes include ischemia, optic nerve neuropathy, glaucoma, trauma, radiation, brain tumors, and multiple sclerosis. it leads to vision disturbances.

• Optic Atrophy 1|Kjer-type Optic Atrophy|OPA1

  an autosomal dominant form of hereditary optic atrophy caused by mutation(s) in the opa1 gene, encoding dynamin-like 120 kda protein, mitochondrial.

• Wolfram Syndrome|DIDMOAD|DIDMOAD|Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness Syndrome

  a rare inherited syndrome caused by mutations in the wfs1 and cisd2 genes. it is characterized by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness.

• Early-Onset Progressive Encephalopathy with Brain Atrophy and Thin Corpus Callosum|Early-Onset Progressive Diffuse Brain Atrophy-Microcephaly-Muscle Weakness-Optic Atrophy Syndrome|PEBAT

  an autosomal recessive condition caused by mutation(s) in the tbcd gene, encoding tubulin-specific chaperone d. it is characterized by encephalopathy, cerebellar and cerebral atrophy, and a thin corpus callosum.

Optic Nerve Disorders

The optic nerve is a bundle of more than 1 million nerve fibers that carry visual messages. You have one connecting the back of each eye (your retina) to your brain. Damage to an optic nerve can cause vision loss. The type of vision loss and how severe it is depends on where the damage occurs. It may affect one or both eyes.

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