2026 ICD-10-CM Diagnosis Code H46.3Toxic optic neuropathy

ICD-10-CM Codes›H00–H59›H46-H47›H46

ICD-10-CM H46.3
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

H46.3 is a billable ICD-10-CM diagnosis code for toxic optic neuropathy. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). Coders also document this condition as alcohol related optic neuropathy. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Drug induced or toxic related condition and Neuro-ophthalmology.

Code Identity

ICD-10-CM Code
H46.3
Billable Status
Yes — Valid for Submission
Code Describes
Toxic optic neuropathy
Short Description
Toxic optic neuropathy
Same as the full description in the CMS dataset.
Parent Code
H46
Optic neuritis

Code Classification

ChapterH00–H59Diseases of the eye and adnexa
SectionH46-H47Disorders of optic nerve and visual pathways
CategoryH46Optic neuritis
This CodeH46.3Toxic optic neuropathy

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Alcohol related optic neuropathy
  • Drug induced optic neuropathy
  • Tobacco related optic neuropathy
  • Toxic optic neuropathy

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Code First

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Neuritis(rheumatoid)
      • optic (nerve) (hereditary) (sympathetic)
        • toxic

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ030
Drug induced or toxic related condition
Default principal diagnosis: inpatient No · outpatient No
CCSR EYE006
Neuro-ophthalmology
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Toxic Optic Neuropathy

    damage to the eye or its function (e.g., visual impairment) due to optic nerve damage secondary to toxic substances such as drugs used in chemotherapy; immunotherapy; or radiation.

Patient EducationClinical

Optic Nerve Disorders

The optic nerve is a bundle of more than 1 million nerve fibers that carry visual messages. You have one connecting the back of each eye (your retina) to your brain. Damage to an optic nerve can cause vision loss. The type of vision loss and how severe it is depends on where the damage occurs. It may affect one or both eyes.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert H46.3 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
377.34 Toxic optic neuropathy
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About H46.3Overview

Is H46.3 (Optic neuritis) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report toxic optic neuropathy on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What is the ICD-9 equivalent of H46.3?

Under the General Equivalence Mappings, toxic optic neuropathy converts to ICD-9-CM 377.34 (toxic optic neuropathy). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.