2026 ICD-10-CM Diagnosis Code F10.221Alcohol dependence with intoxication delirium

ICD-10-CM Codes›F01–F99›F10-F19›F10

ICD-10-CM F10.221
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

F10.221 is a billable ICD-10-CM diagnosis code for alcohol dependence with intoxication delirium. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 894 through 897. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Alcohol-related disorders.

Code Identity

ICD-10-CM Code
F10.221
Billable Status
Yes — Valid for Submission
Code Describes
Alcohol dependence with intoxication delirium
Short Description
Alcohol dependence with intoxication delirium
Same as the full description in the CMS dataset.
Parent Code
F10.22
Alcohol dependence with intoxication

Code Classification

ChapterF01–F99Mental and behavioural disorders
SectionF10-F19Mental and behavioral disorders due to psychoactive substance use
CategoryF10Alcohol related disorders
This CodeF10.221Alcohol dependence with intoxication delirium

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Alcohol, alcoholic, alcohol-induced
      • delirium (acute) (tremens) (withdrawal)
        • with intoxication
          • in
            • dependence
    • Alcohol, alcoholic, alcohol-induced
      • delirium (acute) (tremens) (withdrawal)
        • dependence (acute) (tremens) (withdrawal)
          • with intoxication
    • Alcohol, alcoholic, alcohol-induced
      • intoxication (acute) (without dependence)
        • with
          • dependence
            • with delirium
    • Delirium, delirious(acute or subacute) (not alcohol- or drug-induced)
      • alcoholic (acute) (tremens) (withdrawal)
        • with intoxication
          • in
            • dependence
    • Delirium, delirious(acute or subacute) (not alcohol- or drug-induced)
      • due to (secondary to)
        • alcohol
          • intoxication
            • in
              • dependence
    • Dependence(on) (syndrome)
      • alcohol (ethyl) (methyl) (without remission)
        • with
          • intoxication
            • with delirium
    • Disorder(of)
      • alcohol use
        • moderate or severe
          • with
            • alcohol intoxication
              • delirium

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR MBD017
Alcohol-related disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Alcohol Use Disorder (AUD)

For most adults, moderate alcohol use is probably not harmful. Your risk of developing an alcohol use disorder (AUD) depends on how much, how often, and how quickly you drink alcohol. Alcohol misuse means that drinking causes distress and harm. Over time alcohol misuse can increase your risk of AUD.

The full article covers:

  • What is alcohol use disorder (AUD)?
  • What is binge drinking?
  • What are the dangers of too much alcohol?
  • How do I know if I have an alcohol use disorder (AUD)?
  • What should I do if I think that I might have an alcohol use disorder (AUD)?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert F10.221 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
291.0 Delirium tremens
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About F10.221Overview

Is F10.221 (Alcohol dependence with intoxication) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report alcohol dependence with intoxication delirium on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does F10.221 group to?

When alcohol dependence with intoxication delirium is the principal diagnosis on an inpatient stay, it groups to MS-DRG 894, 895, 896, 897, with relative weights from 0.6169 to 1.7451 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of F10.221?

Under the General Equivalence Mappings, alcohol dependence with intoxication delirium converts to ICD-9-CM 291.0 (delirium tremens). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.