2026 ICD-10-CM Diagnosis Code E74.19Other disorders of fructose metabolism

ICD-10-CM Codes›E00–E89›E70-E88›E74

ICD-10-CM E74.19
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E74.19 is a billable ICD-10-CM diagnosis code for other disorders of fructose metabolism. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 391 through 392. Coders also document this condition as deficiency of 6-phosphofructokinase. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.

Code Identity

ICD-10-CM Code
E74.19
Billable Status
Yes — Valid for Submission
Code Describes
Other disorders of fructose metabolism
Short Description
Other disorders of fructose metabolism
Same as the full description in the CMS dataset.
Parent Code
E74.1
Disorders of fructose metabolism

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE74Other disorders of carbohydrate metabolism
This CodeE74.19Other disorders of fructose metabolism

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Deficiency of 6-phosphofructokinase
  • Deficiency of fructose-bisphosphatase
  • Deficiency of fructose-bisphosphate aldolase
  • Deficiency of triokinase
  • Fructose metabolism disorder
  • Fructose-biphosphatase deficiency

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Fructose-1, 6-diphosphatase deficiency

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END016
Other specified and unspecified nutritional and metabolic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Carbohydrate Metabolism Disorders

Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system (enzymes) break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E74.19 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
271.2 Hered fructose intoleran
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E74.19Overview

What is the ICD-10 code for other disorders of fructose metabolism?

The ICD-10-CM code for other disorders of fructose metabolism is E74.19 (sometimes written as E7419). It is billable on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Is E74.19 (Disorders of fructose metabolism) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other disorders of fructose metabolism on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E74.19 group to?

When other disorders of fructose metabolism is the principal diagnosis on an inpatient stay, it groups to MS-DRG 391, 392, with relative weights from 0.7796 to 1.2683 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E74.19?

Under the General Equivalence Mappings, other disorders of fructose metabolism converts to ICD-9-CM 271.2 (hered fructose intoleran). The mapping is approximate, so confirm the match fits the documentation.