2026 ICD-10-CM Diagnosis Code E74.12Hereditary fructose intolerance
ICD-10-CM Codes›E00–E89›E70-E88›E74
- Billable — Valid for Submission
- Chronic Condition
E74.12 is a billable ICD-10-CM diagnosis code for hereditary fructose intolerance. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 391 through 392. Coders also document this condition as fructose metabolism disorder. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Fructose metabolism disorder
- Fructosuria
- Hereditary fructosuria
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Fructosemia
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Disorder (of) - See Also: Disease;
- fructose metabolism - E74.10
- hereditary fructose intolerance - E74.12
- Fructosemia (benign) (essential) - E74.12
- hereditary - E74.12
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Disorder(of)
- fructose metabolism
- hereditary fructose intolerance
- Fructosemia(benign) (essential)
- Intolerance
- fructose
- hereditary
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Carbohydrate Metabolism Disorders
Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system (enzymes) break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues.
Read the full article at MedlinePlus
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Convert E74.12 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E74.12Overview
Is E74.12 (Disorders of fructose metabolism) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report hereditary fructose intolerance on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does E74.12 group to?
When hereditary fructose intolerance is the principal diagnosis on an inpatient stay, it groups to MS-DRG 391, 392, with relative weights from 0.7796 to 1.2683 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of E74.12?
Under the General Equivalence Mappings, hereditary fructose intolerance converts to ICD-9-CM 271.2 (hered fructose intoleran). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.
