2026 ICD-10-CM Diagnosis Code D57.3Sickle-cell trait
ICD-10-CM Codes›D50–D89›D55-D59›D57
- Billable — Valid for Submission
- Chronic Condition
D57.3 is a billable ICD-10-CM diagnosis code for sickle-cell trait. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 811 through 812. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Sickle cell trait/anemia.
D57.3 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 48 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 48, ESRD (V21) category 48, and ESRD (V24) category 48 for payment year 2026.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
D57.3 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.
Source: CMS Payment Year 2026 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Beta plus thalassemia
- Beta zero thalassemia
- Delta beta thalassemia
- Delta beta zero thalassemia
- Glomerular disease due to hematological disease
- Glomerular disorder due to sickle cell trait
- Gouty arthropathy due to sickle-cell trait
- Hereditary hemoglobin S
- Heterozygous hemoglobinopathy
- Retinopathy due to sickle cell trait
- Sickle cell beta plus thalassemia
- Sickle cell retinopathy
- Sickle cell trait
- Sickle cell trait in mother complicating childbirth
- Sickle cell trait in mother complicating pregnancy
- Sickle cell-beta-thalassemia
- Sickle cell-delta beta^0^-thalassemia
- Sickle cell-thalassemia disease
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Hb-S trait
- Heterozygous hemoglobin S
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Disease, diseased See Also: Syndrome;
AS genotype D57.3
Disorder (of) See Also: Disease;
sickle-cell (sickling) (homozygous) See: Disease, sickle-cell;
heterozygous D57.3
trait D57.3
Hemoglobin See Also: condition;
AS genotype D57.3
S (Hb S), heterozygous D57.3
trait D57.3
Hb-S D57.3
S (Hb-S) D57.3
sickle-cell D57.3
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Sickle Cell Trait
the condition of being heterozygous for hemoglobin s.Sickle Cell Trait
an individual who is heterozygous for the mutation that causes sickle cell anemia.
Patient EducationClinical
Sickle Cell Disease
Sickle cell disease (SCD) is a group of inherited red blood cell disorders. If you have SCD, there is a problem with your hemoglobin. Hemoglobin is a protein in red blood cells that carries oxygen throughout the body. With SCD, the hemoglobin forms into stiff rods within the red blood cells. This changes the shape of the red blood cells.
The full article covers:
- What is sickle cell disease (SCD)?
- What causes sickle cell disease (SCD)?
- Who is more likely to have sickle cell disease (SCD)?
- What are the symptoms of sickle cell disease (SCD)?
- How is sickle cell disease (SCD) diagnosed?
- What are the treatments for sickle cell disease (SCD)?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D57.3 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D57.3Overview
What is the ICD-10 code for sickle-cell trait?
The ICD-10-CM code for sickle-cell trait is D57.3 (sometimes written as D573). It is billable on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
Is D57.3 (Sickle-cell disorders) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report sickle-cell trait on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does D57.3 group to?
When sickle-cell trait is the principal diagnosis on an inpatient stay, it groups to MS-DRG 811, 812, with relative weights from 0.9182 to 1.4043 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of D57.3?
Under the General Equivalence Mappings, sickle-cell trait converts to ICD-9-CM 282.5 (sickle-cell trait). The mapping is a direct match.
Does D57.3 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage. D57.3 mapped to HCC 48 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 48 (Coagulation Defects and Other Specified Hematological Disorders), ESRD (V21) category 48 (Coagulation Defects and Other Specified Hematological Disorders), and ESRD (V24) category 48 (Coagulation Defects and Other Specified Hematological Disorders).
