ICD-10 Diagnosis Code D72.0

Genetic anomalies of leukocytes

Diagnosis Code D72.0

ICD-10: D72.0
Short Description: Genetic anomalies of leukocytes
Long Description: Genetic anomalies of leukocytes
This is the 2017 version of the ICD-10-CM diagnosis code D72.0

Code Classification
  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
    • Other disorders of blood and blood-forming organs (D70-D77)
      • Other disorders of white blood cells (D72)

Information for Medical Professionals

Diagnostic Related Groups
The diagnosis code D72.0 is grouped in the following Diagnostic Related Group(s) (MS-DRG v33.0)


Convert to ICD-9 Additional informationCallout TooltipGeneral Equivalence Map
The ICD-10 and ICD-9 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.
  • 288.2 - Genetic anomaly leukocyt

  • Alders syndrome
  • Combined phagocytic defect
  • Congenital leukocyte adherence deficiency
  • Congenital leukocyte adherence deficiency
  • Congenital leukocyte adherence deficiency
  • De Vaal's syndrome
  • Defective phagocytic cell adhesion
  • Defective phagocytic cell adhesion
  • Defective phagocytic cell adhesion
  • Genetic anomaly of leukocyte
  • Hereditary hypersegmentation
  • Hereditary neutrophilia
  • Hypersegmentation
  • Leukocyte adhesion deficiency - type 1
  • Leukocyte adhesion deficiency - type 2
  • May Hegglin syndrome
  • May-Hegglin anomaly
  • May-Hegglin anomaly
  • Megakaryocytic thrombocytopenia
  • Neutrophilia
  • Neutrophilia
  • Pelger-Huët anomaly
  • Periodontitis co-occurrent with leukocyte adhesion deficiency
  • Quantitative disorder of neutrophils
  • Reticular dysgenesis
  • Reticular dysgenesis with congenital aleukocytosis
  • Severe combined immunodeficiency due to absent peripheral T cell maturation

Index of Diseases and Injuries
References found for the code D72.0 in the Index of Diseases and Injuries:

Information for Patients

Blood Disorders

Also called: Hematologic diseases

Your blood is living tissue made up of liquid and solids. The liquid part, called plasma, is made of water, salts and protein. Over half of your blood is plasma. The solid part of your blood contains red blood cells, white blood cells and platelets.

Blood disorders affect one or more parts of the blood and prevent your blood from doing its job. They can be acute or chronic. Many blood disorders are inherited. Other causes include other diseases, side effects of medicines, and a lack of certain nutrients in your diet.

Types of blood disorders include

  • Platelet disorders, excessive clotting, and bleeding problems, which affect how your blood clots
  • Anemia, which happens when your blood does not carry enough oxygen to the rest of your body
  • Cancers of the blood, such as leukemia and myeloma
  • Eosinophilic disorders, which are problems with one type of white blood cell.

  • Blood differential
  • Blood smear
  • CBC
  • Hematocrit
  • Hemoglobin
  • Low white blood cell count and cancer
  • RBC count
  • RBC indices
  • WBC count

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Genetic Disorders

Genes are the building blocks of heredity. They are passed from parent to child. They hold DNA, the instructions for making proteins. Proteins do most of the work in cells. They move molecules from one place to another, build structures, break down toxins, and do many other maintenance jobs.

Sometimes there is a mutation, a change in a gene or genes. The mutation changes the gene's instructions for making a protein, so the protein does not work properly or is missing entirely. This can cause a medical condition called a genetic disorder.

You can inherit a gene mutation from one or both parents. A mutation can also happen during your lifetime.

There are three types of genetic disorders:

  • Single-gene disorders, where a mutation affects one gene. Sickle cell anemia is an example.
  • Chromosomal disorders, where chromosomes (or parts of chromosomes) are missing or changed. Chromosomes are the structures that hold our genes. Down syndrome is a chromosomal disorder.
  • Complex disorders, where there are mutations in two or more genes. Often your lifestyle and environment also play a role. Colon cancer is an example.

Genetic tests on blood and other tissue can identify genetic disorders.

NIH: National Library of Medicine

  • Genetics

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MYH9-related disorder MYH9-related disorder is a condition that can have many signs and symptoms, including bleeding problems, hearing loss, kidney (renal) disease, and clouding of the lens of the eyes (cataracts).The bleeding problems in people with MYH9-related disorder are due to thrombocytopenia. Thrombocytopenia is a reduced level of circulating platelets, which are cell fragments that normally assist with blood clotting. People with MYH9-related disorder typically experience easy bruising, and affected women have excessive bleeding during menstruation (menorrhagia). The platelets in people with MYH9-related disorder are larger than normal. These enlarged platelets have difficulty moving into tiny blood vessels like capillaries. As a result, the platelet level is even lower in these small vessels, further impairing clotting.Some people with MYH9-related disorder develop hearing loss caused by abnormalities of the inner ear (sensorineural hearing loss). Hearing loss may be present from birth or can develop anytime into late adulthood.An estimated 30 to 70 percent of people with MYH9-related disorder develop renal disease, usually beginning in early adulthood. The first sign of renal disease in MYH9-related disorder is typically protein or blood in the urine. Renal disease in these individuals particularly affects structures called glomeruli, which are clusters of tiny blood vessels that help filter waste products from the blood. The resulting damage to the kidneys can lead to kidney failure and end-stage renal disease (ESRD).Some affected individuals develop cataracts in early adulthood that worsen over time.Not everyone with MYH9-related disorder has all of the major features. All individuals with MYH9-related disorder have thrombocytopenia and enlarged platelets. Most commonly, affected individuals will also have hearing loss and renal disease. Cataracts are the least common sign of this disorder.MYH9-related disorder was previously thought to be four separate disorders: May-Hegglin anomaly, Epstein syndrome, Fechtner syndrome, and Sebastian syndrome. All of these disorders involved thrombocytopenia and enlarged platelets and were distinguished by some combination of hearing loss, renal disease, and cataracts. When it was discovered that these four conditions all had the same genetic cause, they were combined and renamed MYH9-related disorder.
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