2025 ICD-10-CM Diagnosis Code T38.5X2S

Approximate Synonyms

The following list of clinical terms are approximate synonyms, alternative descriptions, or common phrases that might be used by patients, healthcare providers, or medical coders to describe the same condition. These synonyms and related diagnosis terms are often used when searching for an ICD-10 code, especially when the exact medical terminology is unclear. Whether you're looking for lay terms, similar diagnosis names, or common language alternatives, this list can help guide you to the correct ICD-10 classification.

Clinical Classification

Clinical Classifications group individual ICD-10-CM diagnosis codes into broader, clinically meaningful categories. These categories help simplify complex data by organizing related conditions under common clinical themes.

They are especially useful for data analysis, reporting, and clinical decision-making. Even when diagnosis codes differ, similar conditions can be grouped together based on their clinical relevance. Each category is assigned a unique CCSR code that represents a specific clinical concept, often tied to a body system or medical specialty.

Clinical Information

• Allylestrenol

  a synthetic steroid with progestational activity.

• Chlorotrianisene

  a powerful synthetic, non-steroidal estrogen.

• Clomiphene

  a triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. note that enclomiphene and zuclomiphene are the (e) and (z) isomers of clomiphene respectively.

• Desogestrel

  a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents (oral contraceptives, combined).

• Dienestrol

  a synthetic, non-steroidal estrogen structurally related to stilbestrol. it is used, usually as the cream, in the treatment of menopausal and postmenopausal symptoms.

• Diethylstilbestrol

  a synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. it was also used formerly as a growth promoter in animals. according to the fourth annual report on carcinogens (ntp 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (merck, 11th ed)

• Dimethisterone

  a synthetic progestational hormone without significant estrogenic or androgenic properties. it was formerly used as the progestational component in sequential oral contraceptive agents .

• Dydrogesterone

  a synthetic progestational hormone with no androgenic or estrogenic properties. unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation.

• Epimestrol

  a synthetic steroid with estrogenic activity.

• Estradiol

  the 17-beta-isomer of estradiol, an aromatized c18 steroid with hydroxyl group at 3-beta- and 17-beta-position. estradiol-17-beta is the most potent form of mammalian estrogenic steroids.

• Estradiol Congeners

  steroidal compounds related to estradiol, the major mammalian female sex hormone. estradiol congeners include important estradiol precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with estrogenic activities.

• Estradiol Dehydrogenases

  enzymes that catalyze the oxidation of estradiol at the 17-hydroxyl group in the presence of nad+ or nadp+ to yield estrone and nadh or nadph. the 17-hydroxyl group can be in the alpha- or beta-configuration. ec 1.1.1.62

• Estrogen Antagonists

  compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds.

• Estrogen Receptor alpha

  one of the estrogen receptors that has marked affinity for estradiol. its expression and function differs from, and in some ways opposes, estrogen receptor beta.

• Estrogen Receptor Antagonists

  compounds and drugs that bind to and block or inhibit the activation of estrogen receptors.

• Ethinyl Estradiol

  a semisynthetic alkylated estradiol with a 17-alpha-ethinyl substitution. it has high estrogenic potency when administered orally, and is often used as the estrogenic component in oral contraceptives.

• Ethinyl Estradiol-Norgestrel Combination

  ethinyl estradiol and norgestrel given in fixed proportions.

• Receptors, Estradiol

  cytoplasmic proteins that bind estradiol, migrate to the nucleus, and regulate dna transcription.

• Steroid 16-alpha-Hydroxylase

  a liver microsomal cytochrome p450 enzyme that catalyzes the 16-alpha-hydroxylation of a broad spectrum of steroids, fatty acids, and xenobiotics in the presence of molecular oxygen and nadph-ferrihemoprotein reductase. this enzyme is encoded by a number of genes from several cyp2 subfamilies.

• Estriol

  a hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at c3, 16-alpha, and 17-beta position. estriol is a major urinary estrogen. during pregnancy, a large amount of estriol is produced by the placenta. isomers with inversion of the hydroxyl group or groups are called epiestriol.

• Estrone

  an aromatized c18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. it is converted from androstenedione directly, or from testosterone via estradiol. in humans, it is produced primarily by the cyclic ovaries, placenta, and the adipose tissue of men and postmenopausal women.

• Glucuronosyltransferase

  a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. they function as drug-metabolizing enzymes that catalyze the conjugation of udpglucuronic acid to a variety of endogenous and exogenous compounds. ec 2.4.1.17.

• Steryl-Sulfatase

  an arylsulfatase with high specificity towards sulfated steroids. defects in this enzyme are the cause of ichthyosis, x-linked.

• Ethisterone

  17 alpha-hydroxypregn-4-en-20-yn-3-one. a synthetic steroid hormone with progestational effects.

• Gestonorone Caproate

  a long-acting potent progestogen structurally related to progesterone. (from martindale, the extra pharmacopoeia, 30th ed, p1185)

• Hexestrol

  a synthetic estrogen that has been used as a hormonal antineoplastic agent.

• Medrogestone

  6,17-dimethylpregna-4,6-diene-3,20-dione. a synthetic progestational hormone with actions similar to those of progesterone. it is used in the treatment of menstrual irregularities and has also been employed in the treatment of prostatic hypertrophy and endometrial carcinoma.

• Megestrol

  a progestational hormone used most commonly as the acetate ester. as the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. it has also been used in the palliative treatment of breast cancer.

• Megestrol Acetate

  megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. it also has anti-androgenic properties. it is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. megestrol acetate has been approved to treat anorexia and cachexia. (from reynolds jef(ed): martindale: the extra pharmacopoeia (electronic version). micromedex, inc, englewood, co, 1995)

• Mestranol

  the 3-methyl ether of ethinyl estradiol. it must be demethylated to be biologically active. it is used as the estrogen component of many combination oral contraceptives.

• Intrauterine Devices, Medicated

  intrauterine devices that release contraceptive agents.

• Progesterone

  the major progestational steroid that is secreted primarily by the corpus luteum and the placenta. progesterone acts on the uterus, the mammary glands and the brain. it is required in embryo implantation; pregnancy maintenance, and the development of mammary tissue for milk production. progesterone, converted from pregnenolone, also serves as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids.

• Progesterone Congeners

  steroidal compounds related to progesterone, the major mammalian progestational hormone. progesterone congeners include important progesterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with progestational activities.

• Progesterone Reductase

  an enzyme that catalyzes the reduction of a 3 beta-hydroxy-delta(5)-steroid to 3-oxo-delta(4)-steroid in the presence of nad. it converts pregnenolone to progesterone and dehydroepiandrosterone to androstenedione. ec 1.1.1.145.

• Progesterone-Binding Globulin

  a glycoprotein migrating as alpha 1-globulin, molecular weight 70,000 to 120,000. the protein, which is present in increased amounts in the plasma during pregnancy, binds mainly progesterone, with other steroids including testosterone competing weakly.

• Receptors, Progesterone

  specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. the cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. there are two kinds of progesterone receptors, a and b. both are induced by estrogen and have short half-lives.

• Steroid 21-Hydroxylase

  an adrenal microsomal cytochrome p450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and nadph-ferrihemoprotein reductase. this enzyme, encoded by cyp21 gene, converts progesterones to precursors of adrenal steroid hormones (corticosterone; hydrocortisone). defects in cyp21 cause congenital adrenal hyperplasia (adrenal hyperplasia, congenital).

• Promegestone

  a synthetic progestin which is useful for the study of progestin distribution and progestin tissue receptors, as it is not bound by transcortin and binds to progesterone receptors with a higher association constant than progesterone.

• Quinestrol

  the 3-cyclopentyl ether of ethinyl estradiol. after gastrointestinal absorption, it is stored in adipose tissue, slowly released, and metabolized principally to the parent compound. it has been used in estrogen replacement therapy. (from ama drug evaluations annual, 1992, p1011)

Coding Guidelines

When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined. If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified (T38). Use the following options for the aplicable episode of care:

• A - initial encounter
• D - subsequent encounter
• S - sequela

MS-DRG Mapping for ICD-10-CM Code T38.5X2S

Diagnosis-Related Groups (DRGs) are used to classify hospital cases for billing and healthcare management. They help standardize how hospitals and other providers are reimbursed for inpatient care. Patients are grouped based on their principal diagnosis into broader categories called Major Diagnostic Categories (MDCs).

Once assigned to a DRG, the hospital receives a set payment for the patient’s care, regardless of the actual services provided. This fixed rate is intended to cover the typical cost of treating patients within that group. The payment amount depends on the DRG's relative weight, which reflects the expected complexity and cost of care based on the severity of the patient’s condition.

Diagnostic related groups encourage healthcare providers to focus on quality and efficiency in patient care while managing costs effectively. The diagnosis code is present in the following groups for version MS-DRG V42.0 applicable from 10/01/2024 through 09/30/2025.

Present on Admission (POA)

T38.5X2S is exempt from POA reporting - The Present on Admission (POA) indicator is used for diagnosis codes included in claims involving inpatient admissions to general acute care hospitals. POA indicators must be reported to CMS on each claim to facilitate the grouping of diagnoses codes into the proper Diagnostic Related Groups (DRG). CMS publishes a listing of specific diagnosis codes that are exempt from the POA reporting requirement. Review other POA exempt codes here.

CMS POA Indicator Options and Definitions

Convert T38.5X2S to ICD-9-CM

Below are the ICD-9 codes that most closely match this ICD-10 code, based on the General Equivalence Mappings (GEMs). This ICD-10 to ICD-9 crosswalk tool is helpful for coders who need to reference legacy diagnosis codes for audits, historical claims, or approximate code comparisons.

Table of Drugs and Chemicals

The parent code T38.5X2 of the current diagnosis code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.

According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.

Patient Education

Poisoning

A poison is any substance that is harmful to your body. You might swallow it, inhale it, inject it, or absorb it through your skin. Any substance can be poisonous if too much is taken. Poisons can include:

• Prescription or over-the-counter medicines taken in doses that are too high
• Overdoses of illegal drugs
• Carbon monoxide from gas appliances
• Household products, such as laundry powder or furniture polish
• Pesticides
• Indoor or outdoor plants
• Metals such as lead and mercury

The effects of poisoning range from short-term illness to brain damage, coma, and death. To prevent poisoning it is important to use and store products exactly as their labels say. Keep dangerous products where children can't get to them. Treatment for poisoning depends on the type of poison. If you suspect someone has been poisoned, call your local poison control center at 1-800-222-1222 right away.

Self-Harm

What is self-harm?

Self-harm, or self-injury, is when a person hurts his or her own body on purpose. The injuries may be minor, but sometimes they can be severe. They may leave permanent scars or cause serious health problems. Some examples are:

• Cutting yourself (such as using a razor blade, knife, or other sharp object to cut your skin)
• Punching yourself or punching things (like a wall)
• Burning yourself with cigarettes, matches, or candles
• Pulling out your hair
• Poking objects through body openings
• Breaking your bones or bruising yourself

Self-harm is not a mental disorder. It is a behavior - an unhealthy way to cope with strong feelings. However, some of the people who harm themselves do have a mental disorder.

People who harm themselves are usually not trying to attempt suicide. But they are at higher risk of attempting suicide if they do not get help.

Why do people harm themselves?

There are different reasons why people harm themselves. Often, they have trouble coping and dealing with their feelings. They harm themselves to try to:

• Make themselves feel something (because they feel empty or numb inside)
• Block upsetting memories
• Show that they need help
• Release strong feelings that overwhelm them, such as anger, loneliness, or hopelessness
• Punish themselves
• Feel a sense of control

Who is at risk for self-harm?

There are people of all ages who harm themselves, but it usually starts in the teen or early adult years. Self-harm is more common in people who:

• Were abused or went through a trauma as children
• Have mental disorders, such as
  • Depression
  • Eating disorders
  • Post-traumatic stress disorder
  • Certain personality disorders
• Misuse drugs or alcohol
• Have friends who self-harm
• Have low self-esteem

What are the signs of self-harm?

Signs that someone may be hurting themselves include:

• Having frequent cuts, bruises, or scars
• Wearing long sleeves or pants even in hot weather
• Making excuses about injuries
• Having sharp objects around for no clear reason

How can I help someone who self-harms?

If someone you know is self-harming, it is important not to be judgmental. Let that person know that you want to help. If the person is a child or teenager, ask him or her to talk to a trusted adult. If he or she won't do that, talk to a trusted adult yourself. If the person who is self-harming is an adult, suggest mental health counseling.

What the treatments are for self-harm?

There are no medicines to treat self-harming behaviors. But there are medicines to treat any mental disorders that the person may have, such as anxiety and depression. Treating the mental disorder may weaken the urge to self-harm.

Mental health counseling or therapy can also help by teaching the person:

• Problem-solving skills
• New ways to cope with strong emotions
• Better relationship skills
• Ways to strengthen self-esteem

If the problem is severe, the person may need more intensive treatment in a psychiatric hospital or a mental health day program.

Code History

• FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
• FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
• FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
• FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
• FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
• FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
• FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
• FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
• FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.