2024 ICD-10-CM Diagnosis Code T38.5X4

Poisoning by other estrogens and progestogens, undetermined

ICD-10-CM Code:
T38.5X4
ICD-10 Code for:
Poisoning by other estrogens and progestogens, undetermined
Is Billable?
Not Valid for Submission
Code Navigator:

Code Classification

  • Injury, poisoning and certain other consequences of external causes
    (S00–T88)
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
      (T36-T50)
      • Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified
        (T38)

T38.5X4 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of poisoning by other estrogens and progestogens, undetermined. The code is not specific and is NOT valid for the year 2024 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding Applicable to Poisoning by other estrogens and progestogens, undetermined

Non-specific codes like T38.5X4 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for poisoning by other estrogens and progestogens, undetermined:

  • Use T38.5X4A for initial encounter - BILLABLE CODE

  • Use T38.5X4D for subsequent encounter - BILLABLE CODE

  • Use T38.5X4S for sequela - BILLABLE CODE

Clinical Information

  • Allylestrenol

    a synthetic steroid with progestational activity.
  • Chlorotrianisene

    a powerful synthetic, non-steroidal estrogen.
  • Clomiphene

    a triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. note that enclomiphene and zuclomiphene are the (e) and (z) isomers of clomiphene respectively.
  • Desogestrel

    a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents (oral contraceptives, combined).
  • Dienestrol

    a synthetic, non-steroidal estrogen structurally related to stilbestrol. it is used, usually as the cream, in the treatment of menopausal and postmenopausal symptoms.
  • Diethylstilbestrol

    a synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. it was also used formerly as a growth promoter in animals. according to the fourth annual report on carcinogens (ntp 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (merck, 11th ed)
  • Dimethisterone

    a synthetic progestational hormone without significant estrogenic or androgenic properties. it was formerly used as the progestational component in sequential oral contraceptive agents .
  • Dydrogesterone

    a synthetic progestational hormone with no androgenic or estrogenic properties. unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation.
  • Epimestrol

    a synthetic steroid with estrogenic activity.
  • Estradiol

    the 17-beta-isomer of estradiol, an aromatized c18 steroid with hydroxyl group at 3-beta- and 17-beta-position. estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
  • Estradiol Congeners

    steroidal compounds related to estradiol, the major mammalian female sex hormone. estradiol congeners include important estradiol precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with estrogenic activities.
  • Estradiol Dehydrogenases

    enzymes that catalyze the oxidation of estradiol at the 17-hydroxyl group in the presence of nad+ or nadp+ to yield estrone and nadh or nadph. the 17-hydroxyl group can be in the alpha- or beta-configuration. ec 1.1.1.62
  • Estrogen Antagonists

    compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds.
  • Estrogen Receptor alpha

    one of the estrogen receptors that has marked affinity for estradiol. its expression and function differs from, and in some ways opposes, estrogen receptor beta.
  • Estrogen Receptor Antagonists

    compounds and drugs that bind to and block or inhibit the activation of estrogen receptors.
  • Ethinyl Estradiol

    a semisynthetic alkylated estradiol with a 17-alpha-ethinyl substitution. it has high estrogenic potency when administered orally, and is often used as the estrogenic component in oral contraceptives.
  • Ethinyl Estradiol-Norgestrel Combination

    ethinyl estradiol and norgestrel given in fixed proportions.
  • Receptors, Estradiol

    cytoplasmic proteins that bind estradiol, migrate to the nucleus, and regulate dna transcription.
  • Steroid 16-alpha-Hydroxylase

    a liver microsomal cytochrome p450 enzyme that catalyzes the 16-alpha-hydroxylation of a broad spectrum of steroids, fatty acids, and xenobiotics in the presence of molecular oxygen and nadph-ferrihemoprotein reductase. this enzyme is encoded by a number of genes from several cyp2 subfamilies.
  • Estriol

    a hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at c3, 16-alpha, and 17-beta position. estriol is a major urinary estrogen. during pregnancy, a large amount of estriol is produced by the placenta. isomers with inversion of the hydroxyl group or groups are called epiestriol.
  • Estrone

    an aromatized c18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. it is converted from androstenedione directly, or from testosterone via estradiol. in humans, it is produced primarily by the cyclic ovaries, placenta, and the adipose tissue of men and postmenopausal women.
  • Glucuronosyltransferase

    a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. they function as drug-metabolizing enzymes that catalyze the conjugation of udpglucuronic acid to a variety of endogenous and exogenous compounds. ec 2.4.1.17.
  • Steryl-Sulfatase

    an arylsulfatase with high specificity towards sulfated steroids. defects in this enzyme are the cause of ichthyosis, x-linked.
  • Ethisterone

    17 alpha-hydroxypregn-4-en-20-yn-3-one. a synthetic steroid hormone with progestational effects.
  • Gestonorone Caproate

    a long-acting potent progestogen structurally related to progesterone. (from martindale, the extra pharmacopoeia, 30th ed, p1185)
  • Hexestrol

    a synthetic estrogen that has been used as a hormonal antineoplastic agent.
  • Medrogestone

    6,17-dimethylpregna-4,6-diene-3,20-dione. a synthetic progestational hormone with actions similar to those of progesterone. it is used in the treatment of menstrual irregularities and has also been employed in the treatment of prostatic hypertrophy and endometrial carcinoma.
  • Megestrol

    a progestational hormone used most commonly as the acetate ester. as the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. it has also been used in the palliative treatment of breast cancer.
  • Megestrol Acetate

    megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. it also has anti-androgenic properties. it is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. megestrol acetate has been approved to treat anorexia and cachexia. (from reynolds jef(ed): martindale: the extra pharmacopoeia (electronic version). micromedex, inc, englewood, co, 1995)
  • Mestranol

    the 3-methyl ether of ethinyl estradiol. it must be demethylated to be biologically active. it is used as the estrogen component of many combination oral contraceptives.
  • Intrauterine Devices, Medicated

    intrauterine devices that release contraceptive agents.
  • Progesterone

    the major progestational steroid that is secreted primarily by the corpus luteum and the placenta. progesterone acts on the uterus, the mammary glands and the brain. it is required in embryo implantation; pregnancy maintenance, and the development of mammary tissue for milk production. progesterone, converted from pregnenolone, also serves as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids.
  • Progesterone Congeners

    steroidal compounds related to progesterone, the major mammalian progestational hormone. progesterone congeners include important progesterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with progestational activities.
  • Progesterone Reductase

    an enzyme that catalyzes the reduction of a 3 beta-hydroxy-delta(5)-steroid to 3-oxo-delta(4)-steroid in the presence of nad. it converts pregnenolone to progesterone and dehydroepiandrosterone to androstenedione. ec 1.1.1.145.
  • Progesterone-Binding Globulin

    a glycoprotein migrating as alpha 1-globulin, molecular weight 70,000 to 120,000. the protein, which is present in increased amounts in the plasma during pregnancy, binds mainly progesterone, with other steroids including testosterone competing weakly.
  • Receptors, Progesterone

    specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. the cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. there are two kinds of progesterone receptors, a and b. both are induced by estrogen and have short half-lives.
  • Steroid 21-Hydroxylase

    an adrenal microsomal cytochrome p450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and nadph-ferrihemoprotein reductase. this enzyme, encoded by cyp21 gene, converts progesterones to precursors of adrenal steroid hormones (corticosterone; hydrocortisone). defects in cyp21 cause congenital adrenal hyperplasia (adrenal hyperplasia, congenital).
  • Promegestone

    a synthetic progestin which is useful for the study of progestin distribution and progestin tissue receptors, as it is not bound by transcortin and binds to progesterone receptors with a higher association constant than progesterone.
  • Quinestrol

    the 3-cyclopentyl ether of ethinyl estradiol. after gastrointestinal absorption, it is stored in adipose tissue, slowly released, and metabolized principally to the parent compound. it has been used in estrogen replacement therapy. (from ama drug evaluations annual, 1992, p1011)

Coding Guidelines

When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined. If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified (T38). Use the following options for the aplicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Table of Drugs and Chemicals

The code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.

According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.

Substance Poisoning
Accidental
(unintentional)
Poisoning
Accidental
(self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
effect
Underdosing
AllylestrenolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Anhydrohydroxy-progesteroneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
ChlormadinoneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
ChlorotrianiseneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
ChlortrianiseneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
ClomifeneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
ClomipheneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Conjugated estrogenic substancesT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
DelalutinT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
DemegestoneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
DesogestrelT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
DiaethylstilboestrolumT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
DienestrolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
DienoestrolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
DiethylstilbestrolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
DiethylstilboestrolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
DimestrolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
DimethisteroneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
DydrogesteroneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
EpiestriolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
EpimestrolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
EstradiolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Estradiol
  »with testosterone
T38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Estradiol
  »benzoate
T38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
EstriolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
EstrogenT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Estrogen
  »with progesterone
T38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Estrogen
  »conjugated
T38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
EstroneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
EstropipateT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Ethinylestradiol, ethinyloestradiolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Ethinylestradiol, ethinyloestradiol
  »with
T38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Ethinylestradiol, ethinyloestradiol
  »with
    »levonorgestrel
T38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Ethinylestradiol, ethinyloestradiol
  »with
    »norethisterone
T38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
EthisteroneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
FosfestrolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Gestonorone caproateT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
HexestrolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
HexoestrolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
HydroxyestroneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
HydroxyprogesteroneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Hydroxyprogesterone
  »caproate
T38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
IsopregnenoneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Lipo-LutinT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
LutocylolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
LutromoneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
MedrogestoneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Medroxyprogesterone acetate (depot)T38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
MegestrolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
MestranolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
MethallenestrilT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
MethallenoestrilT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
MethylestrenoloneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
NomegestrolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
NoretynodrelT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
NormethandroneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
OestradiolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
OestriolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
OestrogenT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
OestroneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
OvarianT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Ovarian
  »hormone
T38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Ovarian
  »stimulant
T38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
OxendoloneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Polyestradiol phosphateT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Polyoestradiol phosphateT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
PregnandiolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
PregneninoloneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
PremarinT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
ProgesteroneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
ProgestinT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Progestin
  »oral contraceptive
T38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
Progestogen NECT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
ProgestoneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
ProlutonT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
PromegestoneT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
ProveraT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
QuinestradiolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
QuinestradolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
QuinestrolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
StilbestrolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
StilboestrolT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6
TaceT38.5X1T38.5X2T38.5X3T38.5X4T38.5X5T38.5X6

Patient Education


Hormones

Hormones are your body's chemical messengers. They travel in your bloodstream to tissues or organs. They work slowly, over time, and affect many different processes, including:

  • Growth and development
  • Metabolism - how your body gets energy from the foods you eat
  • Sexual function
  • Reproduction
  • Mood

Endocrine glands, which are special groups of cells, make hormones. The major endocrine glands are the pituitary, pineal, thymus, thyroid, adrenal glands, and pancreas. In addition, men produce hormones in their testes and women produce them in their ovaries.

Hormones are powerful. It takes only a tiny amount to cause big changes in cells or even your whole body. That is why too much or too little of a certain hormone can be serious. Laboratory tests can measure the hormone levels in your blood, urine, or saliva. Your health care provider may perform these tests if you have symptoms of a hormone disorder. Home pregnancy tests are similar - they test for pregnancy hormones in your urine.


[Learn More in MedlinePlus]

Poisoning

A poison is any substance that is harmful to your body. You might swallow it, inhale it, inject it, or absorb it through your skin. Any substance can be poisonous if too much is taken. Poisons can include:

  • Prescription or over-the-counter medicines taken in doses that are too high
  • Overdoses of illegal drugs
  • Carbon monoxide from gas appliances
  • Household products, such as laundry powder or furniture polish
  • Pesticides
  • Indoor or outdoor plants
  • Metals such as lead and mercury

The effects of poisoning range from short-term illness to brain damage, coma, and death. To prevent poisoning it is important to use and store products exactly as their labels say. Keep dangerous products where children can't get to them. Treatment for poisoning depends on the type of poison. If you suspect someone has been poisoned, call your local poison control center at 1-800-222-1222 right away.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.