2026 ICD-10-CM Diagnosis Code R89.8Other abnormal findings in specimens from other organs, systems and tissues

AHRQ’s CCSR groups this code into broader clinical categories.

• Gene Amplification

  a selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. it occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an rna transcript of the entire repeating sequence of ribosomal rna followed by the reverse transcription of the molecule to produce an additional copy of the original dna sequence. laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of dna from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.

• Nucleic Acid Conformation

  the spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.

• Point Mutation

  a mutation caused by the substitution of one nucleotide for another. this results in the dna molecule having a change in a single base pair.

• Genetic Variation

  genotypic differences observed among individuals in a population.

• Protein Conformation

  the characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. protein structure, quaternary describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).

• Protein Conformation, alpha-Helical

  a secondary structure of proteins that is a right-handed helix or coil, where each amino (n-h) group of the peptide backbone contributes a hydrogen bond to the carbonyl(c=o) group of the amino acid four residues n-terminal to it (n-4). it is the most common type of secondary structure.

• Protein Conformation, beta-Strand

  a secondary structure of proteins where the amino (n-h) groups of a polypeptide backbone, three to ten amino acids in length, establish hydrogen bonds with the carbonyl (c=o) groups in the backbone of adjacent strands. these may form a beta-sheet, where the side chains of the adjacent strands point in the same direction.

• Carbohydrate Conformation

  the characteristic 3-dimensional shape of a carbohydrate.

• DNA Damage

  injuries to dna that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a mutation or a block of dna replication. these deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. they include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the dna backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (pyrimidine dimers) or interstrand crosslinking. damage can often be repaired (dna repair). if the damage is extensive, it can induce apoptosis.

• DNA Damage Tolerance

  strategies that cells use to continue dna replication when replicative dna polymerases stall at dna damage-blocked replication forks. these dna damage tolerant replication mechanisms bypass the dna damage, which may be repaired subsequently by various dna repair mechanisms.

• DNA Repair

  the removal of dna lesions and/or restoration of intact dna strands without base pair mismatches, intrastrand or interstrand crosslinks, or discontinuities in the dna sugar-phosphate backbones.

• Oxidative Stress

  a disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. indicators of oxidative stress include damaged dna bases, protein oxidation products, and lipid peroxidation products (sies, oxidative stress, 1991, pxv-xvi).

• Transcription Factor CHOP

  a ccaat-enhancer binding protein that is induced by dna damage and growth arrest. it serves as a dominant negative inhibitor of other ccaat-enhancer binding proteins.

• Molecular Conformation

  the characteristic three-dimensional shape of a molecule.

• DNA

  a deoxyribonucleotide polymer that is the primary genetic material of all cells. eukaryotic and prokaryotic organisms normally contain dna in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. dna, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

• DDIT4L Gene|DDIT4L|DDIT4L|DNA Damage Inducible Transcript 4 Like Gene

  this gene plays a role in the mtor signaling pathway, the inhibition of cell growth and dna damage responses.

• DDIT4L wt Allele|DNA Damage Inducible Transcript 4 Like wt Allele|DNA Damage-Inducible Transcript 4-Like Gene|DNA-Damage-Inducible Transcript 4-Like Gene|Homolog of Mouse SMHS1 Gene|REDD2|RTP801L|Regulated In Development and DNA Damage Response 2 Gene|Regulated In Development and DNA Damage Responses 2 Gene|Rtp801L|Similar to Smhs1 Protein Gene

  human ddit4l wild-type allele is located in the vicinity of 4q24 and is approximately 5 kb in length. this allele, which encodes dna damage-inducible transcript 4-like protein, is involved in cell growth inhibition in response to dna damage.

• DNA Damage-Inducible Transcript 4-Like Protein|DDIT4L|HIF-1 Responsive Protein RTP801-Like|Protein Regulated In Development and DNA Damage Response 2|REDD-2

  dna damage-inducible transcript 4-like protein (193 aa, ~28 kda) is encoded by the human ddit4l gene. this protein plays a role in the negative regulation of the mtor signaling pathway.

• Cortical Blindness

  visual impairment due to visual cortex dysfunction.

• Depolymerization

  the process that catabolizes the covalent bonds between monomeric structures in a polymer.

• Microtubule Depolymerization Process|Disassembly of Microtubules|Microtubule Depolymerization

  any microtubule process involving the removal of tubulin heterodimers from one or both ends of a microtubule.

• Negative Regulation of Microtubule Depolymerization|Microtubule Disassembly Inhibition|Microtubule Stabilization

  any microtubule process that stops, prevents or reduces the frequency, rate or extent of microtubule depolymerization.

• Semuloparin|AVE-5026|AVE5026|SEMULOPARIN|ULMW heparin AVE5026|Ultra-low-molecular-weight Heparin (2000-3000 MW; Phosphazene Depolymerization)|Ultralow-Molecular-Weight Heparin AVE5026

  an ultralow-molecular-weight heparin (ulmwh) (mw: 2000-3000 daltons)consisting of a polydisperse mixture of oligomeric heparin fragments with potential anticoagulant activity. ultralow-molecular-weight heparin ave5026 binds to and activates antithrombin iii (atiii), which may result in the inhibition of activated factor xa and, to a much lesser extent, factor iia (thrombin) and so the inhibition of fibrin formation. compared to low-molecular-weight heparins (lmwhs), ave5026 exhibits an even higher ratio of anti-factor xa to anti-factor iia activity (>30:1). compared to unfractionated heparins, the use of lmwhs is associated with lower incidences of major bleeding, osteoporosis and heparin-induced thrombocytopenia. like lmwhs, this agent may inhibit tumor growth by regulating angiogenesis and apoptosis. ave5026 is prepared by partial depolymerization of unfractionated porcine mucosal heparin.

• DDIT3 Gene Rearrangement|C/EBPzeta Gene Rearrangement|CEBPZ Gene Rearrangement|CHOP-10 Gene Rearrangement|CHOP10 Gene Rearrangement|DDIT3 Rearrangement|DNA Damage Inducible Transcript 3 Gene Rearrangement|DNA-Damage-Inducible Transcript 3 Gene Rearrangement|GADD153 Gene Rearrangement

  a molecular abnormality indicating rearrangement of the ddit3 gene.

• DDIT3 Gene|CHOP|DDIT3|DDIT3|DDIT3|DNA Damage Inducible Transcript 3 Gene

  this gene plays a role in the modulation of transcription.

• DDIT3 wt Allele|C/EBP Zeta Gene|C/EBPzeta|CCAAT/Enhancer-Binding Protein Homologous Protein Zeta Gene|CEBPZ|CHOP|CHOP-10|CHOP10|DNA Damage Inducible Transcript 3 wt Allele|DNA-Damage-Inducible Transcript 3 Gene|GADD153|Growth Arrest- and DNA Damage-Inducible 153 Gene|MGC4154

  human ddit3 wild-type allele is located in the vicinity of 12q13.3 and is approximately 4 kb in length. this allele, which encodes dna damage-inducible transcript 3 protein, is involved in transcriptional suppression. two translocations involving the gene, t(12;16)(q13;p11) with the fus gene and t(12;22)(q13;q12) with the ewsr1 gene, are associated with myxoid liposarcoma.

• DDRD Signature|DDRD Gene Signature|DNA Damage Response Deficiency Gene Signature|DNA Damage Response Deficiency Signature

  a gene expression profile that indicates that the cells in a sample have decreased ability to respond to and repair dna damage.

• Deleterious DNA Damage Response Gene Mutation|DDR Deleterious Gene Alteration|DDR Gene Deleterious Alteration|Deleterious DDR Gene Mutation|Deleterious DNA Damage Response (DDR) Gene Alteration|Deleterious DNA Damage Response Gene Alteration

  a change in the nucleotide sequence of a gene involved in any dna damage response pathway that is associated with increased risk of disease.

• DINOL wt Allele|DINO|DNA Damage, p53 is Stabilized and p53-Responsive Gene|Damage Induced Long Noncoding RNA wt Allele|Damage Induced Noncoding RNA Gene|Damage-Induced Non-Coding RNA Gene

  human dinol wild-type allele is located in the vicinity of 6p21.2 and is approximately 1 kb in length. this allele, which encodes damage induced long noncoding rna, plays a role in stabilization of cellular tumor antigen p53.

• DNA Damage

  drug-, radiation-induced, or spontaneous injuries to dna that introduce deviations from its normal double-helical conformation. these changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in dna sequence. if the damage is minor, it can often be repaired (dna repair); extensive damage can induce apoptosis.

• DNA Damage Response Deficiency|DDRD|DNA Damage Repair Deficiency|DNA Damage Response and Repair Deficiency|Deficient DNA Damage Response

  a decrease in the ability of cells to respond to damaged dna and to repair the damage. this dna repair deficiency can be caused by mutations in the genes involved in the dna damage response and/or dna repair.

• DNA Damage Response Gene Mutation|DDR Gene Alteration|DDR Gene Mutation|DNA Damage Response Gene Alteration|DNA Damage Response Gene Alteration

  any change in the nucleotide sequence of a gene involved in dna damage response pathways.

• DNA Damage-Binding Protein 1|DDB p127 Subunit|DDB1|DDBa|DNA Damage-Binding Protein a|Damage-Specific DNA-Binding Protein 1|HBV X-Associated Protein 1|UV-DDB 1|UV-Damaged DNA-Binding Factor|UV-Damaged DNA-Binding Protein 1|XAP-1|XPE-BF|XPE-Binding Factor|Xeroderma Pigmentosum Group E-Complementing Protein

  dna damage-binding protein 1 (1140 aa, ~127 kda) is encoded by the human ddb1 gene. this protein is involved in both protein ubiquitination and dna damage repair.

• DNA Damage-Binding Protein 2|DDB p48 Subunit|DDB2|DDBb|DNA Damage-Binding Protein b|Damage-Specific DNA-Binding Protein 2|UV-DDB 2|UV-Damaged DNA-Binding Protein 2

  dna damage-binding protein 2 (427 aa, ~48 kda) is encoded by the human ddb2 gene. this protein plays a role in the mediation of dna repair.

• DNA Damage-Inducible Transcript 3 Protein|C/EBP-Homologous Protein|C/EBP-Homologous Protein 10|CHOP|CHOP-10|DDIT-3|DDIT3|Growth Arrest and DNA Damage-Inducible Protein GADD153

  dna damage-inducible transcript 3 protein (169 aa, ~19 kda) is encoded by the human ddit3 gene. this protein plays a role in the sequestration of transcription factors.

• DNA Damage-Inducible Transcript 4 Protein|HIF-1 Responsive Protein|Protein Regulated in Development and DNA Damage Response 1|RTP801

  dna damage-inducible transcript 4 protein (232 aa, ~25 kda) is encoded by the human ddit4 gene. this protein is involved in responses to cellular stress and regulates apoptosis in response to dna damage.

• DNA Repair|DNA Damage Repair|Unscheduled DNA Synthesis

  enzymatic restoration of dna structure after chemical, radiation, or spontaneous damage.

• EWSR1/DDIT3 Fusion Protein|EWS-CHOP Fusion Protein|EWS/CHOP Fusion Protein|EWSR1-DDIT3 Fusion Protein|EWSR1::DDIT3 Fusion Protein|RNA-Binding Protein EWS/DNA Damage-Inducible Transcript 3 Protein Fusion Protein

  a fusion protein encoded by the ewsr1/ddit3 fusion gene. this protein is comprised of the transactivation domain of the rna-binding protein ews followed by the dna-binding basic domain and leucine zipper dimerization domain of the dna damage-inducible transcript 3 protein.

• FUS/DDIT3 Fusion Protein|FUS-CHOP Fusion Protein|FUS-DDIT3 Fusion Protein|FUS/CHOP Fusion Protein|FUS::DDIT3 Fusion Protein|RNA-Binding Protein FUS/DNA Damage-Inducible Transcript 3 Protein Fusion Protein|TLS-CHOP Fusion Protein|TLS/CHOP Fusion Protein

  a fusion protein encoded by the fus/ddit3 fusion gene. this protein is comprised of at least half of the rna-binding protein fus followed by the dna-binding basic domain and leucine zipper dimerization domain of the dna damage-inducible transcript 3 protein.

• GADD45A Gene|GADD45A|GADD45A|Growth Arrest and DNA Damage Inducible Alpha Gene

  this gene plays a role in signal transduction and is induced in response to environmental stress. it is involved in apoptosis, dna repair and negative regulation of cell growth.

• GADD45A wt Allele|DDIT1|DNA Damage-Inducible Gene Gadd45|DNA Damage-Inducible Transcript 1 Gene|DNA Damage-Inducible Transcript-1 Gene|DNA-Damage-Inducible Transcript 1 Gene|GADD45|Growth Arrest and DNA Damage Inducible Alpha wt Allele|Growth Arrest and DNA Damage-Inducible Gene 45|Growth Arrest and DNA-Damage-Inducible, Alpha Gene|Growth Arrest- and DNA Damage-Inducible Gene GADD45, Alpha|RP5-975D15.1

  human gadd45a wild-type allele is located within 1p31.2-p31.1 and is approximately 3 kb in length. this allele, which encodes growth arrest and dna-damage-inducible protein gadd45 alpha, is involved in the modulation of cellular responses to environmental stress.

• Growth Arrest and DNA Damage-Inducible Protein GADD45 Alpha|DDIT-1|DNA Damage-Inducible Transcript 1 Protein|GADD45 Gene Product|GADD45A|GADD45A Protein|Growth Arrest and DNA Damage-Inducible Gene 45 Protein|Growth Arrest and DNA-Damage-Inducible 45 Alpha|Growth Arrest and DNA-Damage-Inducible, Alpha

  growth arrest and dna damage-inducible protein gadd45 alpha (165 aa, ~18 kda) is encoded by the human gadd45a gene. this protein is involved in the regulation of mitogenic signaling.

• Growth Arrest and DNA Damage-Inducible Protein GADD45 Beta|GADD45B|Growth Arrest and DNA-Damage-Inducible Beta|Myeloid Differentiation Primary Response Protein MyD118|Negative Growth Regulatory Protein MyD118

  growth arrest and dna damage-inducible protein gadd45 beta (160 aa, ~18 kda) is encoded by the human gadd45b gene. this protein plays a role in the regulation of cell growth, apoptosis and signaling.

• Interferon-Related DNA Damage Resistance Gene Signature|IFN-Related DNA Damage Resistance Signature|IRDS

  an experimental therapy-predictive system used to assess if patient's tumor may be resistant to chemotherapy. this system is based on the expression profile of a panel of genes that are associated with both interferon signaling pathways and resistance to radiation-induced dna damage.

• MDC1 Gene Mutation|Mediator of DNA Damage Checkpoint 1 Gene Mutation|NFBD1 Gene Mutation

  a change in the nucleotide sequence of the mdc1 gene.

• MDC1 Gene|MDC1|MDC1|Mediator of DNA Damage Checkpoint 1 Gene

  this gene plays a role in cell cycle progression.

• MDC1 wt Allele|Em:AB023051.5|KIAA0170|Mediator of DNA Damage Checkpoint 1 wt Allele|Mediator of DNA-Damage Checkpoint 1 Gene|NFBD1

  human mdc1 wild-type allele is located in the vicinity of 6p21.3 and is approximately 18 kb in length. this allele, which encodes mediator of dna damage checkpoint protein 1, is involved in checkpoint mediated cell cycle arrest.

• Mediator of DNA Damage Checkpoint Protein 1|Homolog to Drosophila Photoreceptor Protein Calphotin|MDC1|Mediator of DNA Damage Checkpoint 1|Nuclear Factor with BRCT Domains 1

  mediator of dna damage checkpoint protein 1 (2089 aa, ~227 kda) is encoded by the human mdc1 gene. this protein plays a role in checkpoint mediated cell cycle arrest.

• Oxidative DNA Damage|DNA Oxidation|Oxidative Damage of DNA

  the oxidation of deoxyribonucleosides in dna strands, which may occur due to exposure to reactive oxygen species (ros). under normal conditions, low levels of oxidized nucleosides are present; this steady state level may play a role epigenetic control of gene expression and is maintained by enzymes of the base excision repair (ber) pathway. elevated levels of oxidative dna damage are associated with oxidative stress, tumorigenesis and certain diseases, including neurologic conditions such as alzheimer disease, systemic lupus erythematosus, bipolar disorder and schizophrenia.

• Protein Phosphatase 1 Regulatory Subunit 15A|Growth Arrest and DNA Damage-Inducible Protein GADD34|Myeloid Differentiation Primary Response Protein MyD116 Homolog

  protein phosphatase 1 regulatory subunit 15a (674 aa, ~73 kda) is encoded by the human ppp1r15a gene. this protein is involved in both signaling and phosphatase recruitment.

• Radiation Induced DNA Damage|DNA Damage, Radiation Induced|Genotoxicity, Radiation Induced|Radiation-Induced DNA Damage

  damage to dna caused by ionizing radiation. can cause base change mutations or strand breakage.

• Radiation Induced DNA Damage|Genotoxicity, Radiation Induced|Radiation-Induced DNA Damage

  damage to dna caused by ionizing radiation. can cause base change mutations or strand breakage.

• Tumor Necrosis Factor Receptor Superfamily Member 10B|Apoptosis Inducing Protein TRICK2A/2B|Apoptosis Inducing Receptor TRAIL-R2|CD262 Antigen|Cytotoxic TRAIL Receptor-2|DR5|DR5|Death Domain Containing Receptor For TRAIL/Apo-2L|Death Receptor 5|Fas-Like Protein|Fas-Like Protein Precursor|P53-Regulated DNA Damage-Inducible Cell Death Receptor (Killer)|TNF Receptor Superfamily Member 10b|TNF-Related Apoptosis-Inducing Ligand Receptor 2|TNFRSF10B|TRAIL Receptor 2|TRAIL receptor 2|TRAIL-R2|TRAIL-R2|TRAILR-2|TRAILR2|Tumor Necrosis Factor Receptor-Like Protein ZTNFR9|death receptor 5|tumor necrosis factor receptor superfamily member 10B

  tumor necrosis factor receptor superfamily member 10b (440 aa, ~48 kda) is encoded by the human tnfrsf10b gene. this protein is involved in the modulation of the caspase cascade.

• XPC Gene Mutation|RAD4 Gene Mutation|XP3 Gene Mutation|XPC Complex Subunit, DNA Damage Recognition and Repair Factor Gene Mutation|XPCC Gene Mutation|Xeroderma Pigmentosum, Complementation Group C Gene Mutation

  a change in the nucleotide sequence of the xpc gene.

• XPC Gene|XPC|XPC|XPC|XPC|XPC Complex Subunit, DNA Damage Recognition and Repair Factor Gene

  this gene is involved in nucleotide excision repair.

• XPC wt Allele|RAD4|RAD4, Yeast, Homolog of Gene|XP3|XPC Complex Subunit, DNA Damage Recognition and Repair Factor wt Allele|XPCC|Xeroderma Pigmentosum, Complementation Group C Gene

  human xpc wild-type allele is located in the vicinity of 3p25 and is approximately 34 kb in length. this allele, which encodes dna repair protein complementing xp-c cells protein, plays a role in the regulation of nucleotide excision repair. mutation of the gene is associated with xeroderma pigmentosum complementation group c.

• Semuloparin|AVE 5026|AVE-5026|AVE5026|SEMULOPARIN|ULMW heparin AVE5026|Ultra-low-molecular-weight Heparin (2000-3000 MW; Phosphazene Depolymerization)|Ultralow-Molecular-Weight Heparin AVE5026

  an ultralow-molecular-weight heparin (ulmwh) (mw: 2000-3000 daltons)consisting of a polydisperse mixture of oligomeric heparin fragments with potential anticoagulant activity. ultralow-molecular-weight heparin ave5026 binds to and activates antithrombin iii (atiii), which may result in the inhibition of activated factor xa and, to a much lesser extent, factor iia (thrombin) and so the inhibition of fibrin formation. compared to low-molecular-weight heparins (lmwhs), ave5026 exhibits an even higher ratio of anti-factor xa to anti-factor iia activity (>30:1). compared to unfractionated heparins, the use of lmwhs is associated with lower incidences of major bleeding, osteoporosis and heparin-induced thrombocytopenia. like lmwhs, this agent may inhibit tumor growth by regulating angiogenesis and apoptosis. ave5026 is prepared by partial depolymerization of unfractionated porcine mucosal heparin.

• DNA Damage Response Deficiency Negative|DDR Deficiency Negative|DDRD Absent|DDRD Negative

  an indication that genetic markers for dna damage response deficiency were not detected in a sample.

• DNA Repair Gene|DNA Damage Repair Gene|DNA Damage Repair Gene

  dna repair genes encode dna repair proteins, involved in enzymatic restoration of dna structure after chemical, radiation, or spontaneous damage. (nci)