2026 ICD-10-CM Diagnosis Code R74.01Elevation of levels of liver transaminase levels

ICD-10-CM Codes›R00–R99›R70-R79›R74

ICD-10-CM R74.01
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

R74.01 is a billable ICD-10-CM diagnosis code for elevation of levels of liver transaminase levels. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 947 through 948. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established. Coders also document this condition as alanine aminotransferase above reference range. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Abnormal findings without diagnosis.

Code Identity

ICD-10-CM Code
R74.01
Billable Status
Yes — Valid for Submission
Code Describes
Elevation of levels of liver transaminase levels
Short Description
Elevation of levels of liver transaminase levels
Same as the full description in the CMS dataset.
Parent Code
R74.0
Nonspecific elevation of levels of transaminase and lactic acid dehydrogenase [LDH]

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR70-R79Abnormal findings on examination of blood, without diagnosis
CategoryR74Abnormal serum enzyme levels
This CodeR74.01Elevation of levels of liver transaminase levels

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Alanine aminotransferase above reference range
  • Alanine aminotransferase outside reference range
  • Aspartate aminotransferase serum level above reference range
  • Aspartate transaminase level
  • Aspartate transaminase level above reference range
  • Elevated level of transaminase and lactic acid dehydrogenase
  • Serum aspartate aminotransferase level outside reference range

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Elevation of levels of alanine transaminase (ALT)
  • Elevation of levels of aspartate transaminase (AST)

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR SYM017
Abnormal findings without diagnosis
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

ALT Blood Test

An ALT test measures the amount of ALT in your blood. This test is commonly used to help diagnose liver damage or disease.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code History & ChangesHistory

Replacement R74.01 replaces the following previously assigned code(s):

  • R74.0 - Nonspec elev of levels of transamns & lactic acid dehydrgnse
FY 2021AddedAdded to the ICD-10-CM code setEffective October 1, 2020.
FY 2022–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About R74.01Overview

What is the ICD-10 code for elevation of levels of liver transaminase levels?

The ICD-10-CM code for elevation of levels of liver transaminase levels is R74.01 (sometimes written as R7401). It is billable on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Is R74.01 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report elevation of levels of liver transaminase levels on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does R74.01 group to?

When elevation of levels of liver transaminase levels is the principal diagnosis on an inpatient stay, it groups to MS-DRG 947, 948, with relative weights from 0.8005 to 1.2694 depending on complications. Higher weights mean higher Medicare reimbursement.

Can R74.01 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the elevation of levels of liver transaminase levels is established, that condition takes the principal position instead.