2026 ICD-10-CM Diagnosis Code R53.82Chronic fatigue, unspecified

ICD-10-CM Codes›R00–R99›R50-R69›R53

ICD-10-CM R53.82
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

R53.82 is a billable ICD-10-CM diagnosis code for chronic fatigue, unspecified. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 947 through 948. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established. Coders also document this condition as chronic fatigue syndrome. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Malaise and fatigue.

Code Identity

ICD-10-CM Code
R53.82
Billable Status
Yes — Valid for Submission
Code Describes
Chronic fatigue, unspecified
Short Description
Chronic fatigue, unspecified
Same as the full description in the CMS dataset.
Parent Code
R53.8
Other malaise and fatigue

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR50-R69General symptoms and signs
CategoryR53Malaise and fatigue
This CodeR53.82Chronic fatigue, unspecified

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Chronic fatigue syndrome
  • Tired
  • Tired all the time

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Type 1 Excludes

  • chronic fatigue syndrome G93.32
  • myalgic encephalomyelitis G93.32
  • other post infection and related fatigue syndromes G93.39
  • postviral fatigue syndrome G93.31

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Fatigue
      • chronic

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR SYM007
Malaise and fatigue
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, long-term illness that affects many body systems. Another name for it is chronic fatigue syndrome (CFS). ME/CFS can often make you unable to do your usual activities. Sometimes you may not even be able to get out of bed.

The full article covers:

  • What is myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?
  • What causes myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?
  • Who is more likely to develop myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?
  • What are the symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?
  • How is myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) diagnosed?
  • What are the treatments for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert R53.82 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
780.71 Chronic fatigue syndrome
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About R53.82Overview

Is R53.82 (Other malaise and fatigue) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report chronic fatigue, unspecified on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does R53.82 group to?

When chronic fatigue, unspecified is the principal diagnosis on an inpatient stay, it groups to MS-DRG 947, 948, with relative weights from 0.8005 to 1.2694 depending on complications. Higher weights mean higher Medicare reimbursement.

Can R53.82 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the chronic fatigue, unspecified is established, that condition takes the principal position instead.

What is the ICD-9 equivalent of R53.82?

Under the General Equivalence Mappings, chronic fatigue, unspecified converts to ICD-9-CM 780.71 (chronic fatigue syndrome). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.