2026 ICD-10-CM Diagnosis Code R53.0Neoplastic (malignant) related fatigue
ICD-10-CM Codes›R00–R99›R50-R69›R53
- Billable — Valid for Submission
- Not Chronic
R53.0 is a billable ICD-10-CM diagnosis code for neoplastic (malignant) related fatigue. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 947 through 948. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established. Coders also document this condition as cancer-related fatigue. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Conditions due to neoplasm or the treatment of neoplasm and Malaise and fatigue.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Cancer-related fatigue
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Code First
- associated neoplasm
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.
Index to Diseases and InjuriesGuidance
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Fatigue
- neoplasm-related
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Cancer
Cancer is not just one disease but many diseases. Cancer begins in your cells, which are the building blocks of your body. Usually, your body forms new cells as needed, replacing old cells that die. Sometimes this process goes wrong. New cells grow even when you don't need them, and old cells don't die when they should.
The full article covers:
- What is cancer?
- What are the types of cancer?
- How does cancer develop?
- What are the symptoms of cancer?
- How is cancer diagnosed?
- What are the treatments for cancer?
- Can cancer be prevented?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert R53.0 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About R53.0Overview
Is R53.0 (Malaise and fatigue) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report neoplastic (malignant) related fatigue on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does R53.0 group to?
When neoplastic (malignant) related fatigue is the principal diagnosis on an inpatient stay, it groups to MS-DRG 947, 948, with relative weights from 0.8005 to 1.2694 depending on complications. Higher weights mean higher Medicare reimbursement.
Can R53.0 be a principal diagnosis?
Use it with care. This is a symptom code, so once a definitive diagnosis explaining the neoplastic (malignant) related fatigue is established, that condition takes the principal position instead.
What is the ICD-9 equivalent of R53.0?
Under the General Equivalence Mappings, neoplastic (malignant) related fatigue converts to ICD-9-CM 780.79 (malaise and fatigue NEC). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
