2026 ICD-10-CM Diagnosis Code F19.27Other psychoactive substance dependence with psychoactive substance-induced persisting dementia

ICD-10-CM Codes›F01–F99›F10-F19›F19

ICD-10-CM F19.27
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

F19.27 is a billable ICD-10-CM diagnosis code for other psychoactive substance dependence with psychoactive substance-induced persisting dementia. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 894 through 897. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Neurocognitive disorders and Other specified substance-related disorders.

Code Identity

ICD-10-CM Code
F19.27
Billable Status
Yes — Valid for Submission
Code Describes
Other psychoactive substance dependence with psychoactive substance-induced persisting dementia
Short Description
Oth psychoactive substance dependence w persisting dementia
Parent Code
F19.2
Other psychoactive substance dependence

Code Classification

ChapterF01–F99Mental and behavioural disorders
SectionF10-F19Mental and behavioral disorders due to psychoactive substance use
CategoryF19Other psychoactive substance related disorders
This CodeF19.27Other psychoactive substance dependence with psychoactive substance-induced persisting dementia

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Other (or unknown) substance use disorder, moderate, with other (or unknown) substance induced major neurocognitive disorder
  • Other (or unknown) substance use disorder, severe, with other (or unknown) substance induced major neurocognitive disorder

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Dementia(degenerative (primary)) (persisting) (unspecified severity) (without behavioral disturbance, psychotic disturbance, mood disturbance, and anxiety)
      • in (due to)
        • psychoactive drug
          • with dependence
    • Dependence(on) (syndrome)
      • drug NEC
        • psychoactive NEC
          • with
            • dementia
    • Disorder(of)
      • cognitive
        • persisting
          • due to
            • specified substance NEC
              • with
                • dependence
    • Disorder(of)
      • substance use (other) (unknown)
        • moderate or severe
          • with substance-induced
            • major neurocognitive disorder

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NVS011
Neurocognitive disorders
Default principal diagnosis: inpatient No · outpatient No
CCSR MBD025
Other specified substance-related disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Dementia

Dementia is a loss of mental functions that is severe enough to affect your daily life and activities. These functions include:

The full article covers:

  • What is dementia?
  • What are the types of dementia?
  • Who is at risk for dementia?
  • What are the symptoms of dementia?
  • How is dementia diagnosed?
  • What are the treatments for dementia?
  • Can dementia be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert F19.27 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
292.82 Drug persisting dementia
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.
ICD-9-CM
304.60 Drug depend NEC-unspec
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About F19.27Overview

Is F19.27 (Other psychoactive substance dependence) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other psychoactive substance dependence with psychoactive substance-induced persisting dementia on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does F19.27 group to?

When other psychoactive substance dependence with psychoactive substance-induced persisting dementia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 894, 895, 896, 897, with relative weights from 0.6169 to 1.7451 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of F19.27?

Under the General Equivalence Mappings, other psychoactive substance dependence with psychoactive substance-induced persisting dementia converts to ICD-9-CM 292.82 (drug persisting dementia) and 304.60 (drug depend NEC-unspec). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.