2026 ICD-10-CM Diagnosis Code C88Malignant immunoproliferative diseases and certain other B-cell lymphomas

ICD-10-CM Codes›C00–D49›C81-C96›C88

ICD-10-CM C88
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

C88 is a non-billable ICD-10-CM category code for malignant immunoproliferative diseases and certain other B-cell lymphomas, so it cannot be submitted on claims. Use a more specific code from this category instead, such as C88.00, C88.01, C88.20, and C88.21.

Code Identity

ICD-10-CM Code
C88
Billable Status
No — Non-Billable Category
Code Describes
Malignant immunoproliferative diseases and certain other B-cell lymphomas
Short Description
Malig immunoproliferative dis and certain oth B-cell lymph
Chapter
C81-C96
Malignant neoplasms of lymphoid, hematopoietic and related tissue

Code Classification

ChapterC00–D49Neoplasms
SectionC81-C96Malignant neoplasms of lymphoid, hematopoietic and related tissue
CategoryC88Malignant immunoproliferative diseases and certain other B-cell lymphomas
This CodeC88Malignant immunoproliferative diseases and certain other B-cell lymphomas

Specific Coding for Malig immunoproliferative dis and certain oth B-cell lymphOverview

Non-specific codes like C88 require more characters. Use one of these billable codes instead:

  • C88.0 for Waldenstrom macroglobulinemia

  • Use C88.00 for Waldenstrom macroglobulinemia not having achieved remission

  • Use C88.01 for Waldenstrom macroglobulinemia, in remission

  • C88.2 for Heavy chain disease

  • Use C88.20 for Heavy chain disease not having achieved remission

  • Use C88.21 for Heavy chain disease, in remission

  • C88.3 for Immunoproliferative small intestinal disease

  • Use C88.30 for Immunoproliferative small intestinal disease not having achieved remission

  • Use C88.31 for Immunoproliferative small intestinal disease, in remission

  • C88.4 for Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]

  • Use C88.40 for Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma] not having achieved remission

  • Use C88.41 for Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma], in remission

  • C88.8 for Other malignant immunoproliferative diseases

  • Use C88.80 for Other malignant immunoproliferative diseases not having achieved remission

  • Use C88.81 for Other malignant immunoproliferative diseases, in remission

  • C88.9 for Malignant immunoproliferative disease, unspecified

  • Use C88.90 for Malignant immunoproliferative disease, unspecified not having achieved remission

  • Use C88.91 for Malignant immunoproliferative disease, unspecified, in remission

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Type 1 Excludes

  • B-cell lymphoma, unspecified C85.1
  • personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues Z85.79

Patient EducationClinical

Lymphoma

Lymphoma is a cancer of a part of the immune system called the lymph system. There are many types of lymphoma. One type is Hodgkin disease. The rest are called non-Hodgkin lymphomas.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About C88Overview

Is C88 a billable code?

No. This is a category header that groups the codes for malignant immunoproliferative diseases and certain other B-cell lymphomas, and headers cannot be submitted on claims. Claims for malignant immunoproliferative diseases and certain other B-cell lymphomas need a more specific code from this category, such as C88.00, C88.01, and C88.20.