2027 ICD-10-CM Diagnosis Code C88Malignant immunoproliferative diseases and certain other B-cell lymphomas

ICD-10-CM Codes›C00–D49›C81-C96›C88

ICD-10-CM C88
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

C88 is a non-billable ICD-10-CM category code for malignant immunoproliferative diseases and certain other B-cell lymphomas, so it cannot be submitted on claims. Use a more specific code from this category instead, such as C88.00, C88.01, C88.20, and C88.21.

Code Identity

ICD-10-CM Code
C88
Billable Status
No — Non-Billable Category
Code Describes
Malignant immunoproliferative diseases and certain other B-cell lymphomas
Short Description
Malig immunoproliferative dis and certain oth B-cell lymph
Chapter
C81-C96
Malignant neoplasms of lymphoid, hematopoietic and related tissue

Code Classification

ChapterC00–D49Neoplasms
SectionC81-C96Malignant neoplasms of lymphoid, hematopoietic and related tissue
CategoryC88Malignant immunoproliferative diseases and certain other B-cell lymphomas
This CodeC88Malignant immunoproliferative diseases and certain other B-cell lymphomas

Specific Coding for Malig immunoproliferative dis and certain oth B-cell lymphOverview

Non-specific codes like C88 require more characters. Use one of these billable codes instead:

  • C88.0 for Waldenstrom macroglobulinemia

  • Use C88.00 for Waldenstrom macroglobulinemia not having achieved remission

  • Use C88.01 for Waldenstrom macroglobulinemia, in remission

  • C88.2 for Heavy chain disease

  • Use C88.20 for Heavy chain disease not having achieved remission

  • Use C88.21 for Heavy chain disease, in remission

  • C88.3 for Immunoproliferative small intestinal disease

  • Use C88.30 for Immunoproliferative small intestinal disease not having achieved remission

  • Use C88.31 for Immunoproliferative small intestinal disease, in remission

  • C88.4 for Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]

  • Use C88.40 for Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma] not having achieved remission

  • Use C88.41 for Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma], in remission

  • C88.8 for Other malignant immunoproliferative diseases

  • Use C88.80 for Other malignant immunoproliferative diseases not having achieved remission

  • Use C88.81 for Other malignant immunoproliferative diseases, in remission

  • C88.9 for Malignant immunoproliferative disease, unspecified

  • Use C88.90 for Malignant immunoproliferative disease, unspecified not having achieved remission

  • Use C88.91 for Malignant immunoproliferative disease, unspecified, in remission

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to C88: its own notes plus those printed at block C81-C96 and Chapter 2. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

  • B-cell lymphoma, unspecified (C85.1-)
  • personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues (Z85.79)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block C81-C96 Malignant neoplasms of lymphoid, hematopoietic and related tissue applies to 533 codes
  • Kaposi's sarcoma of lymph nodes (C46.3)
  • secondary and unspecified neoplasm of lymph nodes (C77.-)
  • secondary neoplasm of bone marrow (C79.52)
  • secondary neoplasm of spleen (C78.89)

Notes

General instructions on how these codes are used.

From Chapter 2 (C00-D49) Neoplasms applies to 1,730 codes
  • Functional activity
  • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
  • Morphology [Histology]
  • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
  • Primary malignant neoplasms overlapping site boundaries
  • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
  • Malignant neoplasm of ectopic tissue
  • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name C88, its category, or a range that includes it.

Applicable To 1

These notes mention C88.

  • Z85.79 Personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues
    Conditions classifiable to C88-C90, C96

Excludes1 1

These codes carry an Excludes1 note naming C88: they are not reported together with it, unless the two conditions are unrelated.

  • C77 Secondary and unspecified malignant neoplasm of lymph nodes
    malignant neoplasm of lymph nodes, specified as primary (C81-C86, C88, C96.-)

Patient EducationClinical

Lymphoma

Lymphoma is a cancer of a part of the immune system called the lymph system. There are many types of lymphoma. One type is Hodgkin disease. The rest are called non-Hodgkin lymphomas.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About C88Overview

Is C88 a billable code?

No. This is a category header that groups the codes for malignant immunoproliferative diseases and certain other B-cell lymphomas, and headers cannot be submitted on claims. Claims for malignant immunoproliferative diseases and certain other B-cell lymphomas need a more specific code from this category, such as C88.00, C88.01, and C88.20.

Can C88 be reported with a code from C85.1?

Not as a rule. The Excludes1 note on C88 lists "B-cell lymphoma, unspecified (C85.1-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).