ICD-10-CM Code C85.1

Unspecified B-cell lymphoma

Version 2021 Non-Billable Code

Not Valid for Submission

C85.1 is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of unspecified b-cell lymphoma. The code is NOT valid for the year 2021 for the submission of HIPAA-covered transactions.

Short Description:Unspecified B-cell lymphoma
Long Description:Unspecified B-cell lymphoma

Consider the following ICD-10 codes with a higher level of specificity:

  • C85.10 - ... unspecified site
  • C85.11 - ... lymph nodes of head, face, and neck
  • C85.12 - ... intrathoracic lymph nodes
  • C85.13 - ... intra-abdominal lymph nodes
  • C85.14 - ... lymph nodes of axilla and upper limb
  • C85.15 - ... lymph nodes of inguinal region and lower limb
  • C85.16 - ... intrapelvic lymph nodes
  • C85.17 - ... spleen
  • C85.18 - ... lymph nodes of multiple sites
  • C85.19 - ... extranodal and solid organ sites

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code C85.1:

  • If B-cell lineage or involvement is mentioned in conjunction with a specific lymphoma, code to the more specific description.

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code C85.1 are found in the index:

Clinical Information

  • B CELL CLL LYMPHOMA 10 PROTEIN-. a signal transducing adaptor protein that contains an n terminal card domain and functions in the adaptive immune response. it promotes pro caspase 9 maturation and apoptosis activation of nf kappa b and is a substrate for malt1 paracaspase.
  • B CELL LYMPHOMA 3 PROTEIN-. a member of the i kappa b family b cell lymphoma 3 encoded bcl 3 protein is involved in the regulation of transcriptional activation of nf kappa b target genes.
  • LYMPHOMA B CELL-. a group of heterogeneous lymphoid tumors generally expressing one or more b cell antigens or representing malignant transformations of b lymphocytes.
  • PROTO ONCOGENE PROTEINS C BCL 6-. a dna binding protein that contains an n terminal btb poz domain and c terminal cys2 his2 zinc fingers. it represses genetic transcription of target genes by recruiting histone deacetylases. aberrant blc 6 expression is associated with certain types of human b cell lymphoma.

Code Classification

  • Neoplasms (C00–D48)
    • Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96)
      • Oth and unspecified types of non-Hodgkin lymphoma (C85)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Information for Patients


Also called: Non-Hodgkin lymphoma

Lymphoma is a cancer of a part of the immune system called the lymph system. There are many types of lymphoma. One type is Hodgkin disease. The rest are called non-Hodgkin lymphomas.

Non-Hodgkin lymphomas begin when a type of white blood cell, called a T cell or B cell, becomes abnormal. The cell divides again and again, making more and more abnormal cells. These abnormal cells can spread to almost any other part of the body. Most of the time, doctors don't know why a person gets non-Hodgkin lymphoma. You are at increased risk if you have a weakened immune system or have certain types of infections.

Non-Hodgkin lymphoma can cause many symptoms, such as

  • Swollen, painless lymph nodes in the neck, armpits or groin
  • Unexplained weight loss
  • Fever
  • Soaking night sweats
  • Coughing, trouble breathing or chest pain
  • Weakness and tiredness that don't go away
  • Pain, swelling or a feeling of fullness in the abdomen

Your doctor will diagnose lymphoma with a physical exam, blood tests, a chest x-ray, and a biopsy. Treatments include chemotherapy, radiation therapy, targeted therapy, biological therapy, or therapy to remove proteins from the blood. Targeted therapy uses substances that attack cancer cells without harming normal cells. Biologic therapy boosts your body's own ability to fight cancer. If you don't have symptoms, you may not need treatment right away. This is called watchful waiting.

NIH: National Cancer Institute

  • After chemotherapy - discharge (Medical Encyclopedia)
  • B-cell leukemia/lymphoma panel (Medical Encyclopedia)
  • Bone marrow transplant (Medical Encyclopedia)
  • Burkitt lymphoma (Medical Encyclopedia)
  • Lymph node biopsy (Medical Encyclopedia)
  • Non-Hodgkin lymphoma (Medical Encyclopedia)
  • Non-Hodgkin lymphoma - children (Medical Encyclopedia)

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