2027 ICD-10-CM Diagnosis Code B00.81Herpesviral hepatitis

ICD-10-CM Codes›A00–B99›B00-B09›B00

ICD-10-CM B00.81
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

B00.81 is a billable ICD-10-CM diagnosis code for herpesviral hepatitis. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 393 through 395, 791, 793, 974 through 976. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 12 closely related codes. Coders also document this condition as Epstein-Barr virus hepatitis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Hepatitis and Viral infection.

Code Identity

ICD-10-CM Code
B00.81
Billable Status
Yes — Valid for Submission
Code Describes
Herpesviral hepatitis
Short Description
Herpesviral hepatitis
Same as the full description in the CMS dataset.
Parent Code
B00.8
Other forms of herpesviral infections

Code Classification

ChapterA00–B99Certain infectious and parasitic diseases
SectionB00-B09Viral infections characterized by skin and mucous membrane lesions
CategoryB00Herpesviral [herpes simplex] infections
This CodeB00.81Herpesviral hepatitis

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Epstein-Barr virus hepatitis
  • Hepatitis caused by human herpes simplex virus

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to B00.81: its own notes plus those printed at B00 and Chapter 1. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From Chapter 1 (A00-B99) Certain infectious and parasitic diseases applies to 1,068 codes
  • diseases generally recognized as communicable or transmissible

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From B00 Herpesviral [herpes simplex] infections applies to 15 codes
  • congenital herpesviral infections (P35.2)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From B00 Herpesviral [herpes simplex] infections applies to 15 codes
  • anogenital herpesviral infection (A60.-)
  • gammaherpesviral mononucleosis (B27.0-)
  • herpangina (B08.5)
From Chapter 1 (A00-B99) Certain infectious and parasitic diseases applies to 1,068 codes
  • carrier or suspected carrier of infectious disease (Z22.-)
  • certain localized infections - see body system-related chapters
  • infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium (O98.-)
  • infectious and parasitic diseases specific to the perinatal period (P35-P39)
  • influenza and other acute respiratory infections (J00-J22)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

From Chapter 1 (A00-B99) Certain infectious and parasitic diseases applies to 1,068 codes
  • code to identify resistance to antimicrobial drugs (Z16.-)

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name B00.81, its category, or a range that includes it.

Excludes1 1

These codes carry an Excludes1 note naming B00.81: they are not reported together with it, unless the two conditions are unrelated.

  • K77 Liver disorders in diseases classified elsewhere
    herpesviral [herpes simplex] hepatitis (B00.81)

Excludes2 4

These codes carry an Excludes2 note naming B00.81: its condition is not part of those codes, and both may be reported when the patient has both.

  • Block B15-B19 Viral hepatitis
    herpesviral [herpes simplex] hepatitis (B00.81)
  • B10 Other human herpesviruses
    herpes simplex (B00.-) names B00.-, which includes this code
  • B10 Other human herpesviruses
    human herpesvirus NOS (B00.-) names B00.-, which includes this code
  • B10 Other human herpesviruses
    human herpesvirus 1 and 2 (B00.-) names B00.-, which includes this code

Code Also 1

These codes say B00.81 may also be needed to fully describe the condition. The note gives no sequencing direction.

  • D81.82 Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]
    herpes virus infections (B00.-) names B00.-, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INF007
Hepatitis
Default principal diagnosis: inpatient Yes · outpatient Yes
CCSR INF008
Viral infection
Default principal diagnosis: inpatient No · outpatient No

Patient EducationClinical

Herpes Simplex

Herpes is an infection that is caused by a herpes simplex virus (HSV). Oral herpes causes cold sores around the mouth or face. Genital herpes affects the genitals, buttocks or anal area. Genital herpes is a sexually transmitted infection (STI). It affects the genitals, buttocks or anal area.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert B00.81 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
054.71 Visceral herpes simplex
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About B00.81Overview

What is the ICD-10 code for herpesviral hepatitis?

The ICD-10-CM code for herpesviral hepatitis is B00.81 (sometimes written as B0081). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is B00.81 (Other forms of herpesviral infections) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report herpesviral hepatitis on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does B00.81 group to?

When herpesviral hepatitis is the principal diagnosis on an inpatient stay, it groups to MS-DRG 793, 791, 394, 974, 976, 975, 395, 393, with relative weights from 0.6379 to 4.2192 depending on complications. Higher weights mean higher Medicare reimbursement.

Is B00.81 a CC or MCC?

CMS lists B00.81 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 12 closely related codes in its exclusion list.

Can B00.81 be reported with P35.2?

Not as a rule. The Excludes1 note at B00, which applies to B00.81, lists "congenital herpesviral infections (P35.2)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).