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  6. 2026 ICD-10-CM Code R74.8

2026 ICD-10-CM Diagnosis Code R74.8

Abnormal levels of other serum enzymes

ICD-10-CM Code:
R74.8
ICD-10 Code for:
Abnormal levels of other serum enzymes
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Not chronic
Code Navigator:

R74.8 is a billable diagnosis code used to specify a medical diagnosis of abnormal levels of other serum enzymes. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2025 through September 30, 2026.

According to ICD-10-CM guidelines this code should not to be used as a principal diagnosis code when a related definitive diagnosis has been established.

Code Classification

  • Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
    R00–R99
    • Abnormal findings on examination of blood, without diagnosis
      R70-R79
      • Abnormal serum enzyme levels
        R74

Approximate Synonyms

The following list of clinical terms are approximate synonyms, alternative descriptions, or common phrases that might be used by patients, healthcare providers, or medical coders to describe the same condition. These synonyms and related diagnosis terms are often used when searching for an ICD-10 code, especially when the exact medical terminology is unclear. Whether you're looking for lay terms, similar diagnosis names, or common language alternatives, this list can help guide you to the correct ICD-10 classification.

  • Absence of renin secretion
  • Absent renal function
  • Alkaline phosphatase above reference range
  • Alkaline phosphatase bone isoenzyme above reference range
  • Alkaline phosphatase bone isoenzyme below reference range
  • Creatine kinase below reference range
  • Creatine kinase below reference range
  • Creatine kinase level above reference range
  • Deficiency of alkaline phosphatase
  • Finding of gamma-glutamyl transferase level
  • Finding of gamma-glutamyl transferase level
  • Finding of gamma-glutamyl transferase level
  • Finding of plasma creatine kinase level
  • Finding of plasma creatine kinase level
  • Finding of serum creatine kinase level
  • Finding of serum creatine kinase level
  • Finding of serum creatine kinase level
  • Gamma-enolase level above reference range
  • Gamma-glutamyl transferase above reference range
  • Gamma-glutamyl transferase below reference range
  • Gamma-glutamyl transferase level outside reference range
  • High lipase level in serum
  • Intestinal alkaline phosphatase above reference range
  • Intestinal alkaline phosphatase below reference range
  • Isolated asymptomatic elevation of creatine phosphokinase
  • Liver enzymes level above reference range
  • Liver enzymes level above reference range due to cystic fibrosis
  • Low alkaline phosphatase due to chronic kidney disease
  • Pancreatic enzyme level above reference range
  • Placental alkaline phosphatase above reference range
  • Placental alkaline phosphatase below reference range
  • Plasma creatine kinase above reference range
  • Plasma creatine kinase below reference range
  • Serum 5-nucleotidase level above reference range
  • Serum acid phosphatase above reference range
  • Serum acid phosphatase below reference range
  • Serum alkaline phosphatase above reference range
  • Serum alkaline phosphatase below reference range
  • Serum alkaline phosphatase level - finding
  • Serum alkaline phosphatase level - finding
  • Serum amylase above reference range
  • Serum amylase outside reference range
  • Serum amylase above reference range
  • Serum creatine kinase above reference range
  • Serum creatine kinase below reference range
  • Serum lactate dehydrogenase level above reference range

Clinical Classification

Clinical Classifications group individual ICD-10-CM diagnosis codes into broader, clinically meaningful categories. These categories help simplify complex data by organizing related conditions under common clinical themes.

They are especially useful for data analysis, reporting, and clinical decision-making. Even when diagnosis codes differ, similar conditions can be grouped together based on their clinical relevance. Each category is assigned a unique CCSR code that represents a specific clinical concept, often tied to a body system or medical specialty.

Abnormal findings without diagnosis

CCSR Code: SYM017

Inpatient Default: Y - Yes, default inpatient assignment for principal diagnosis or first-listed diagnosis.

Outpatient Default: Y - Yes, default outpatient assignment for principal diagnosis or first-listed diagnosis.

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Abnormal level of acid phosphatase
  • Abnormal level of alkaline phosphatase
  • Abnormal level of amylase
  • Abnormal level of lipase triacylglycerol lipase

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Index of External Cause of Injuries

References found for this diagnosis code in the External Cause of Injuries Index:

    • Abnormal, abnormality, abnormalities
      • serum level (of)
        • acid phosphatase
    • Abnormal, abnormality, abnormalities
      • serum level (of)
        • alkaline phosphatase
    • Abnormal, abnormality, abnormalities
      • serum level (of)
        • amylase
    • Abnormal, abnormality, abnormalities
      • serum level (of)
        • enzymes
          • specified NEC
    • Abnormal, abnormality, abnormalities
      • serum level (of)
        • lipase
    • Abnormal, abnormality, abnormalities
      • serum level (of)
        • triacylglycerol lipase
    • Elevated, elevation
      • liver function
        • test
          • alkaline phosphatase
    • Elevated, elevation
      • liver function
        • test
          • hepatic enzyme

Convert R74.8 to ICD-9-CM

Below are the ICD-9 codes that most closely match this ICD-10 code, based on the General Equivalence Mappings (GEMs). This ICD-10 to ICD-9 crosswalk tool is helpful for coders who need to reference legacy diagnosis codes for audits, historical claims, or approximate code comparisons.

Abn serum enzy level NEC

ICD-9-CM: 790.5

Approximate Flag - The approximate mapping means this ICD-10 code does not have an exact ICD-9 equivalent. The matched code is the closest available option, but it may not fully capture the original diagnosis or clinical intent.

View Conversion

Code History

  • FY 2026 - No Change, effective from 10/1/2025 through 9/30/2026
  • FY 2025 - No Change, effective from 10/1/2024 through 9/30/2025
  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.