2024 ICD-10-CM Diagnosis Code T46.995D

Adverse effect of other agents primarily affecting the cardiovascular system, subsequent encounter

ICD-10-CM Code:
T46.995D
ICD-10 Code for:
Adverse effect of agents aff the cardiovascular sys, subs
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Not chronic
Code Navigator:

Code Classification

  • Injury, poisoning and certain other consequences of external causes
    (S00–T88)
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
      (T36-T50)
      • Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system
        (T46)

T46.995D is a billable diagnosis code used to specify a medical diagnosis of adverse effect of other agents primarily affecting the cardiovascular system, subsequent encounter. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024. The code is exempt from present on admission (POA) reporting for inpatient admissions to general acute care hospitals.

This code describes a circumstance which influences the patient's health status but not a current illness or injury. The code is unacceptable as a principal diagnosis.

T46.995D is a subsequent encounter code, includes a 7th character and should be used after the patient has completed active treatment for a condition like adverse effect of other agents primarily affecting the cardiovascular system. According to ICD-10-CM Guidelines a "subsequent encounter" occurs when the patient is receiving routine care for the condition during the healing or recovery phase of treatment. Subsequent diagnosis codes are appropriate during the recovery phase, no matter how many times the patient has seen the provider for this condition. If the provider needs to adjust the patient's care plan due to a setback or other complication, the encounter becomes active again.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Adverse reaction to adrenochrome
  • Adverse reaction to capillary-active drug
  • Adverse reaction to platelet aggregation inhibitor
  • Cardiac inotropic agent adverse reaction
  • Cardiac inotropic agent adverse reaction
  • Enoximone adverse reaction
  • Hemorrhage after administration of thrombolytic agent
  • Milrinone adverse reaction
  • Phosphodiesterase inhibitor adverse reaction
  • Phosphodiesterase inhibitor adverse reaction

Clinical Classification

Clinical Information

  • Aconitine

    a c19 norditerpenoid alkaloid (diterpenes) from the root of aconitum; delphinium and larkspurs. it activates voltage-gated sodium channels. it has been used to induce arrhythmias in experimental animals and it has anti-inflammatory and anti-neuralgic properties.
  • Adrenochrome

    pigment obtained by the oxidation of epinephrine.
  • Diosmin

    a bioflavonoid that strengthens vascular walls.
  • Hesperidin

    a flavanone glycoside found in citrus fruit peels.

Coding Guidelines

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system (T46). Use the following options for the aplicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Code Edits

The Medicare Code Editor (MCE) detects and reports errors in the coding of claims data. The following ICD-10-CM Code Edits are applicable to this code:

  • Unacceptable principal diagnosis - There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)

T46.995D is exempt from POA reporting - The Present on Admission (POA) indicator is used for diagnosis codes included in claims involving inpatient admissions to general acute care hospitals. POA indicators must be reported to CMS on each claim to facilitate the grouping of diagnoses codes into the proper Diagnostic Related Groups (DRG). CMS publishes a listing of specific diagnosis codes that are exempt from the POA reporting requirement. Review other POA exempt codes here.

CMS POA Indicator Options and Definitions

POA IndicatorReason for CodeCMS will pay the CC/MCC DRG?
YDiagnosis was present at time of inpatient admission.YES
NDiagnosis was not present at time of inpatient admission.NO
UDocumentation insufficient to determine if the condition was present at the time of inpatient admission.NO
WClinically undetermined - unable to clinically determine whether the condition was present at the time of inpatient admission.YES
1Unreported/Not used - Exempt from POA reporting. NO

Convert T46.995D to ICD-9-CM

  • ICD-9-CM Code: V58.89 - Other specfied aftercare
    Approximate Flag - The approximate mapping means there is not an exact match between the ICD-10 and ICD-9 codes and the mapped code is not a precise representation of the original code.

Table of Drugs and Chemicals

The parent code T46.995 of the current diagnosis code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.

According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.

Substance Poisoning
Accidental
(unintentional)
Poisoning
Accidental
(self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
effect
Underdosing
Aconite (wild)T46.991T46.992T46.993T46.994T46.995T46.996
AconitineT46.991T46.992T46.993T46.994T46.995T46.996
Aconitum feroxT46.991T46.992T46.993T46.994T46.995T46.996
AdrenochromeT46.991T46.992T46.993T46.994T46.995T46.996
Adrenochrome
  » (mono) semicarbazone
T46.991T46.992T46.993T46.994T46.995T46.996
Adrenochrome
  »derivative
T46.991T46.992T46.993T46.994T46.995T46.996
AurantiinT46.991T46.992T46.993T46.994T46.995T46.996
BenzopyroneT46.991T46.992T46.993T46.994T46.995T46.996
Bioflavonoid (s)T46.991T46.992T46.993T46.994T46.995T46.996
Chlorisondamine chlorideT46.991T46.992T46.993T46.994T46.995T46.996
DiosminT46.991T46.992T46.993T46.994T46.995T46.996
EscinT46.991T46.992T46.993T46.994T46.995T46.996
EthoxazorutosideT46.991T46.992T46.993T46.994T46.995T46.996
Flavodic acidT46.991T46.992T46.993T46.994T46.995T46.996
HesperidinT46.991T46.992T46.993T46.994T46.995T46.996
LeucocianidolT46.991T46.992T46.993T46.994T46.995T46.996
MetescufyllineT46.991T46.992T46.993T46.994T46.995T46.996
NaftazoneT46.991T46.992T46.993T46.994T46.995T46.996
PhenopyrazoneT46.991T46.992T46.993T46.994T46.995T46.996
PholedrineT46.991T46.992T46.993T46.994T46.995T46.996
RutinumT46.991T46.992T46.993T46.994T46.995T46.996
RutosideT46.991T46.992T46.993T46.994T46.995T46.996
TribenosideT46.991T46.992T46.993T46.994T46.995T46.996
TroxerutinT46.991T46.992T46.993T46.994T46.995T46.996

Patient Education


Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

What is a drug interaction?

A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs, foods, or supplements or when taken while you have certain medical conditions. Examples include:

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as gingko and blood thinners
  • Drugs and medical conditions, such as aspirin and peptic ulcers

Interactions could cause a drug to be more or less effective, cause side effects, or change the way one or both drugs work.

What are side effects?

Side effects are unwanted, usually unpleasant, effects caused by medicines. Most are mild, such as a stomachache, dry mouth, or drowsiness, and go away after you stop taking the medicine. Others can be more serious. Sometimes a drug can interact with a disease that you have and cause a side effect. For example, if you have a heart condition, certain decongestants can cause you to have a rapid heartbeat.

What are drug allergies?

Drug allergies are another type of reaction. They can range from mild to life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is less common.

How can I stay safe when taking medicines?

When you start a new prescription or over-the-counter medicine, make sure you understand how to take it correctly. Know which other medicines, foods, and supplements you need to avoid. Always talk to your health care provider or pharmacist if you have questions about your medicines.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.