2026 ICD-10-CM Diagnosis Code R89.4Abnormal immunological findings in specimens from other organs, systems and tissues

ICD-10-CM Codes›R00–R99›R83-R89›R89

ICD-10-CM R89.4
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

R89.4 is a billable ICD-10-CM diagnosis code for abnormal immunological findings in specimens from other organs, systems and tissues. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 947 through 948. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Abnormal findings without diagnosis.

Code Identity

ICD-10-CM Code
R89.4
Billable Status
Yes — Valid for Submission
Code Describes
Abnormal immunological findings in specimens from other organs, systems and tissues
Short Description
Abnormal immunolog findings in specimens from oth org/tiss
Parent Code
R89
Abnormal findings in specimens from other organs, systems and tissues

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR83-R89Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
CategoryR89Abnormal findings in specimens from other organs, systems and tissues
This CodeR89.4Abnormal immunological findings in specimens from other organs, systems and tissues

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Abnormal blood test
  • Adrenal antibody detected
  • Anergy
  • Antibody to extractable nuclear antigen detected
  • Antineutrophil cytoplasmic antibody detected
  • Anti-nuclear factor detected
  • Bence Jones protein detected
  • Borrelia burgdorferi immunoglobulin G and M antibodies detected
  • Borrelia burgdorferi immunoglobulin G antibody detected
  • Borrelia burgdorferi immunoglobulin M antibody detected
  • CDX2 antigen detected
  • Clonal anergy
  • Complement level below reference range
  • Contact sensitivity response - finding
  • Delayed hypersensitivity skin test for histoplasmin positive
  • Finding of Heaf test
  • Flare reaction
  • Free immunoglobulin light chain above reference range
  • Heaf test grade 1
  • Heaf test grade 1-2
  • Heaf test grade 2
  • Heaf test grade 3
  • Heaf test grade 4
  • Heaf: positive
  • HLA-A*31:01 detected
  • HLA-B*15:02 detected
  • HLA-B*57:01 detected
  • HLA-B*58:01 positive
  • Horse erythrocyte antigen test positive
  • Human leukocyte antigen B5701 detected
  • Human leukocyte antigen DQB1*02:02 positive
  • Immunoglobulin above reference range
  • Immunoglobulin below reference range
  • Immunoglobulins outside reference range
  • Interferon gamma assay positive
  • Interferon gamma assay result indeterminate
  • Irregular blood group antibody detected
  • Kveim test positive
  • La antibody detected
  • Local untoward skin test reaction
  • Loss of normal antigens
  • Lyme detected by enzyme-linked immunosorbent assay
  • Lyme detected by immunoblot
  • Mitochondrial antibodies detected
  • Mitochondrial antibodies weakly detected
  • Monoclonal abnormal heavy chain protein devoid of light chains detected
  • Monoclonal alpha heavy chain detected
  • Monoclonal free kappa light chain detected
  • Monoclonal free lambda light chain detected
  • Monoclonal free light chain detected
  • Monoclonal gamma heavy chain detected
  • Monoclonal immunoglobulin A detected
  • Monoclonal immunoglobulin D detected
  • Monoclonal immunoglobulin E detected
  • Monoclonal immunoglobulin G detected
  • Monoclonal immunoglobulin M detected
  • Monoclonal mu heavy chain detected
  • Paraprotein detected
  • Plasma membrane antigenic alteration
  • Ribonucleoprotein antibody detected
  • Ro antibody detected
  • Rubella virus antibody detected
  • Serum monoclonal band present
  • Skin reaction - finding
  • Skin reaction extreme
  • Skin reaction strong
  • Skin test reaction conversion
  • Sm antibody detected
  • Smooth muscle antibodies detected
  • Smooth muscle antibodies weakly detected
  • Specimen contains cold agglutinins
  • Susceptibility skin test abnormal
  • Susceptibility to sarcoid response - finding
  • Systemic untoward skin test reaction
  • Target cell of immunologic reaction
  • Untoward skin test reaction
  • Zika virus IgM antibody detected

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Abnormal, abnormality, abnormalities
      • immunological findings
    • Abnormal, abnormality, abnormalities
      • specimen
        • specified organ, system and tissue NOS
          • immunology

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR SYM017
Abnormal findings without diagnosis
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Clonal Anergy

    functional inactivation of t- or b-lymphocytes rendering them incapable of eliciting an immune response to antigen. this occurs through different mechanisms in the two kinds of lymphocytes and can contribute to self tolerance.

  • Self Tolerance

    the normal lack of the ability to produce an immunological response to autologous (self) antigens. a breakdown of self tolerance leads to autoimmune diseases. the ability to recognize the difference between self and non-self is the prime function of the immune system.

Convert R89.4 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
792.9 Abn find-body subst NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About R89.4Overview

Is R89.4 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report abnormal immunological findings in specimens from other organs, systems and tissues on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does R89.4 group to?

When abnormal immunological findings in specimens from other organs, systems and tissues is the principal diagnosis on an inpatient stay, it groups to MS-DRG 947, 948, with relative weights from 0.8005 to 1.2694 depending on complications. Higher weights mean higher Medicare reimbursement.

Can R89.4 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the abnormal immunological findings in specimens from other organs, systems and tissues is established, that condition takes the principal position instead.

What is the ICD-9 equivalent of R89.4?

Under the General Equivalence Mappings, abnormal immunological findings in specimens from other organs, systems and tissues converts to ICD-9-CM 792.9 (abn find-body subst NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.