2026 ICD-10-CM Diagnosis Code R89.0Abnormal level of enzymes in specimens from other organs, systems and tissues

ICD-10-CM Codes›R00–R99›R83-R89›R89

ICD-10-CM R89.0
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

R89.0 is a billable ICD-10-CM diagnosis code for abnormal level of enzymes in specimens from other organs, systems and tissues. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 947 through 948. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Abnormal findings without diagnosis.

Code Identity

ICD-10-CM Code
R89.0
Billable Status
Yes — Valid for Submission
Code Describes
Abnormal level of enzymes in specimens from other organs, systems and tissues
Short Description
Abnormal level of enzymes in specimens from oth org/tiss
Parent Code
R89
Abnormal findings in specimens from other organs, systems and tissues

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR83-R89Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
CategoryR89Abnormal findings in specimens from other organs, systems and tissues
This CodeR89.0Abnormal level of enzymes in specimens from other organs, systems and tissues

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Aspartate transaminase level
  • Aspartate transaminase level above reference range
  • Cardiac enzyme above reference range
  • Cardiac enzyme levels - finding
  • Cardiac enzymes outside reference range
  • Cholesterol esters above reference range
  • Creatine kinase below reference range
  • Drug induction of cytochrome p450 CYP1A2 enzyme
  • Drug induction of cytochrome p450 CYP2C19 enzyme
  • Drug induction of cytochrome p450 CYP2C9 enzyme
  • Drug induction of cytochrome p450 CYP3A enzyme
  • Drug inhibition of cytochrome p450 CYP1A2 enzyme
  • Drug inhibition of cytochrome p450 CYP2C19 enzyme
  • Drug inhibition of cytochrome p450 CYP2C9 enzyme
  • Drug inhibition of cytochrome p450 CYP2D6 enzyme
  • Drug inhibition of cytochrome p450 CYP3A enzyme
  • Immunoreactive trypsinogen level above reference range
  • Serum aspartate aminotransferase level outside reference range
  • Substance induction of cytochrome p450 CYP1A2 enzyme
  • Substance induction of cytochrome p450 CYP2E1 enzyme
  • Substance induction of cytochrome p450 CYP3A enzyme
  • Substance induction of cytochrome p450 enzyme
  • Substance inhibition of cytochrome p450 CYP3A enzyme
  • Substance inhibition of cytochrome p450 enzyme

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Abnormal, abnormality, abnormalities
      • specimen
        • specified organ, system and tissue NOS
          • enzyme level

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR SYM017
Abnormal findings without diagnosis
Default principal diagnosis: inpatient Yes · outpatient Yes

Convert R89.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
792.9 Abn find-body subst NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About R89.0Overview

Is R89.0 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report abnormal level of enzymes in specimens from other organs, systems and tissues on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does R89.0 group to?

When abnormal level of enzymes in specimens from other organs, systems and tissues is the principal diagnosis on an inpatient stay, it groups to MS-DRG 947, 948, with relative weights from 0.8005 to 1.2694 depending on complications. Higher weights mean higher Medicare reimbursement.

Can R89.0 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the abnormal level of enzymes in specimens from other organs, systems and tissues is established, that condition takes the principal position instead.

What is the ICD-9 equivalent of R89.0?

Under the General Equivalence Mappings, abnormal level of enzymes in specimens from other organs, systems and tissues converts to ICD-9-CM 792.9 (abn find-body subst NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.