2026 ICD-10-CM Diagnosis Code R53.83Other fatigue

ICD-10-CM Codes›R00–R99›R50-R69›R53

ICD-10-CM R53.83
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

R53.83 is a billable ICD-10-CM diagnosis code for other fatigue. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 947 through 948. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Malaise and fatigue.

Code Identity

ICD-10-CM Code
R53.83
Billable Status
Yes — Valid for Submission
Code Describes
Other fatigue
Short Description
Other fatigue
Same as the full description in the CMS dataset.
Parent Code
R53.8
Other malaise and fatigue

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR50-R69General symptoms and signs
CategoryR53Malaise and fatigue
This CodeR53.83Other fatigue

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Asthenia
  • Difficulty eating
  • Difficulty eating due to fatigue
  • Exhausted on least exertion
  • Exhaustion
  • Exhaustion - physiological
  • Extreme exhaustion
  • Fatigability
  • Fatigue
  • Fatigue due to and following cerebrovascular accident
  • Fatigue due to and following cerebrovascular accident with intracranial hemorrhage
  • Fatigue due to and following embolic cerebrovascular accident
  • Fatigue due to and following ischemic cerebrovascular accident
  • Fatigue due to chemotherapy
  • Fatigue due to radiation therapy
  • Fatigue due to treatment
  • Fatigue with AIDS
  • Finding of general energy
  • Finding of general stamina
  • Heavy feeling
  • Increased need for rest
  • Lack of energy
  • Lack of stamina
  • Lethargy
  • Malaise
  • Malaise and fatigue
  • Occasionally tired
  • Overwork
  • Postexertional fatigue
  • Quickly exhausted
  • Reduced level of fatigue
  • Sensation of heaviness in limbs
  • Tired
  • Tired on least exertion
  • Tires quickly
  • Underactive infant
  • Underexertion

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Fatigue NOS
  • Lack of energy
  • Lethargy
  • Tiredness

Type 2 Excludes

  • exhaustion and fatigue due to depressive episode F32

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Exhaustion, exhaustive(physical NEC)
    • Fatigue
    • Fatigue
      • general
    • Lack of
      • energy
    • Lethargy
    • Overstrained
    • Overworked
    • Prostration
    • Tiredness
    • Vitality, lack or want of

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR SYM007
Malaise and fatigue
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Alert Fatigue, Health Personnel

    mental fatigue experienced by health care providers who encounter numerous alerts and reminders from the use of clinical decision support systems. as the numbers of alerts and reminders designed to provide meaningful assistance to the patient care process increases, many health personnel may ignore them.

  • Asthenopia

    term generally used to describe complaints related to refractive error, ocular muscle imbalance, including pain or aching around the eyes, burning and itchiness of the eyelids, ocular fatigue, and headaches.

  • Auditory Fatigue

    loss of sensitivity to sounds as a result of auditory stimulation, manifesting as a temporary shift in auditory threshold. the temporary threshold shift, tts, is expressed in decibels.

  • Compassion Fatigue

    emotional distress caused by repeated or prolonged expression of compassion or empathy. it may occur in individuals working in care giving professions.

  • Emotional Exhaustion

    a state of feeling emotionally overextended and drained.

  • Fatigue

    the state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.

  • Fatigue Syndrome, Chronic

    a syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. there is also considerable overlap between this condition and fibromyalgia. (from semin neurol 1998;18(2):237-42; ann intern med 1994 dec 15;121(12): 953-9)

  • Fractures, Stress

    fractures due to the strain caused by repetitive exercise. they are thought to arise from a combination of muscle fatigue and bone failure, and occur in situations where bone remodeling predominates over repair. the most common sites of stress fractures are the metatarsus; fibula; tibia; and femoral neck.

  • Heat Stress Disorders

    a group of conditions that develop due to overexposure or overexertion in excessive environmental heat.

  • Mental Fatigue

    a condition of low alertness or cognitive impairment, usually associated with prolonged mental activities or stress.

  • Muscle Fatigue

    a state arrived at through prolonged and strong contraction of a muscle. studies in athletes during prolonged submaximal exercise have shown that muscle fatigue increases in almost direct proportion to the rate of muscle glycogen depletion. muscle fatigue in short-term maximal exercise is associated with oxygen lack and an increased level of blood and muscle lactic acid, and an accompanying increase in hydrogen-ion concentration in the exercised muscle.

  • Voice Disorders

    pathological processes that affect voice production, usually involving vocal cords and the laryngeal mucosa. voice disorders can be caused by organic (anatomical), or functional (emotional or psychological) factors leading to dysphonia; aphonia; and defects in voice quality, loudness, and pitch.

  • Asthenia

    clinical sign or symptom manifested as debility, or lack or loss of strength and energy.

  • Neurocirculatory Asthenia

    a clinical syndrome characterized by palpitation, shortness of breath, labored breathing, subjective complaints of effort and discomfort, all following slight physical exertion. other symptoms may be dizziness, tremulousness, sweating, and insomnia. neurocirculatory asthenia is most typically seen as a form of anxiety disorder.

  • Lethargy

    a general state of sluggishness, listless, or uninterested, with being tired, and having difficulty concentrating and doing simple tasks. it may be related to depression or drug addiction.

  • Fibromyalgia

    a common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). muscle pain is typically aggravated by inactivity or exposure to cold. this condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, headaches, and occasionally depression. there is significant overlap between fibromyalgia and the chronic fatigue syndrome (fatigue syndrome, chronic). fibromyalgia may arise as a primary or secondary disease process. it is most frequent in females aged 20 to 50 years. (from adams et al., principles of neurology, 6th ed, p1494-95)

  • Grade 2 Fatigue, CTCAE|CTCAE Grade 2 Fatigue (asthenia, lethargy, malaise)|Grade 2 Fatigue|Grade 2 Fatigue (asthenia, lethargy, malaise)

    fatigue not relieved by rest; limiting instrumental adl or mild/moderate impact on age-appropriate normal daily activity (pediatric)

  • Grade 2 Malaise, CTCAE|Grade 2 Malaise

    uneasiness or lack of well being limiting instrumental adl or mild/moderate impact on age-appropriate normal daily activity (pediatric)

  • Grade 3 Fatigue, CTCAE|CTCAE Grade 3 Fatigue (asthenia, lethargy, malaise)|Grade 3 Fatigue|Grade 3 Fatigue (asthenia, lethargy, malaise)

    fatigue not relieved by rest, limiting self-care adl or severe impact on age-appropriate normal daily activity (pediatric)

  • Grade 3 Malaise, CTCAE|Grade 3 Malaise

    uneasiness or lack of well being limiting self-care adl or severe impact on age-appropriate normal daily activity (pediatric)

  • How Often Experience Extreme Exhaustion Question|Frequency Experiencing Extreme Exhaustion|How Often Experience Extreme Exhaustion|How often did you experience extreme exhaustion

    a question about how often an individual experiences or experienced extreme exhaustion.

  • Fatigue, CTCAE 3.0|Fatigue (asthenia, lethargy, malaise)

    an unfavorable feeling of fatigue temporally associated with the use of a medical treatment or procedure.

  • Grade 1 Fatigue, CTCAE|CTCAE Grade 1 Fatigue (asthenia, lethargy, malaise)|Grade 1 Fatigue|Grade 1 Fatigue (asthenia, lethargy, malaise)

    fatigue relieved by rest

  • Grade 1 Malaise, CTCAE|Grade 1 Malaise

    uneasiness or lack of well being

  • Grade 2 Fatigue, CTCAE|CTCAE Grade 2 Fatigue (asthenia, lethargy, malaise)|Grade 2 Fatigue|Grade 2 Fatigue (asthenia, lethargy, malaise)

    fatigue not relieved by rest; limiting instrumental adl

  • Grade 2 Malaise, CTCAE|Grade 2 Malaise

    uneasiness or lack of well being limiting instrumental adl

  • Grade 3 Fatigue, CTCAE|CTCAE Grade 3 Fatigue (asthenia, lethargy, malaise)|Grade 3 Fatigue|Grade 3 Fatigue (asthenia, lethargy, malaise)

    fatigue not relieved by rest, limiting self care adl

  • Grade 3 Malaise, CTCAE|Grade 3 Malaise

    uneasiness or lack of well being limiting self-care adl

  • Malaise

    a feeling of general discomfort or uneasiness, an out-of-sorts feeling.

  • Malaise, CTCAE|Malaise|Malaise

    a disorder characterized by a feeling of general discomfort or uneasiness, an out-of-sorts feeling.

  • Post-Exertional Malaise|Post Exertional Malaise

    a feeling of malaise after physical or mental effort or stress.

  • Extreme Exhaustion

    extreme fatigue; inability to respond to stimuli.

  • How Often Experience Extreme Exhaustion|Frequency Experiencing Extreme Exhaustion|How often did you experience extreme exhaustion

    a question about how often an individual experiences or experienced extreme exhaustion.

  • PROMIS IB Version 1.0 Fatigue SF 7a - Often Extreme Exhaustion|PA136-Often Extreme Exhaustion|PA136-Often Extreme Exhaustion|PA136002

    promis item bank version 1.0 fatigue short form 7a (promis ib version 1.0 fatigue sf 7a) how often did you experience extreme exhaustion?

Patient EducationClinical

Fatigue

Fatigue is a feeling of weariness, tiredness, or lack of energy. It can interfere with your usual daily activities. Fatigue can be a normal response to physical activity, emotional stress, boredom, or lack of sleep. But sometimes it can be a sign of a mental or physical condition.

The full article covers:

  • What is fatigue?
  • What causes fatigue?
  • What can I do to manage fatigue?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert R53.83 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
780.79 Malaise and fatigue NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About R53.83Overview

Is R53.83 (Other malaise and fatigue) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other fatigue on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does R53.83 group to?

When other fatigue is the principal diagnosis on an inpatient stay, it groups to MS-DRG 947, 948, with relative weights from 0.8005 to 1.2694 depending on complications. Higher weights mean higher Medicare reimbursement.

Can R53.83 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the other fatigue is established, that condition takes the principal position instead.

What is the ICD-9 equivalent of R53.83?

Under the General Equivalence Mappings, other fatigue converts to ICD-9-CM 780.79 (malaise and fatigue NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.