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  6. 2026 ICD-10-CM Code M35

2026 ICD-10-CM Diagnosis Code M35

Other systemic involvement of connective tissue

ICD-10-CM Code:
M35
ICD-10 Code for:
Other systemic involvement of connective tissue
Is Billable?
Not Valid for Submission
Code Navigator:

M35 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity from the list below for a diagnosis of other systemic involvement of connective tissue. The code is not specific and is NOT valid for the year 2026 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding Applicable to Other systemic involvement of connective tissue

Non-specific codes like M35 require more digits to indicate the appropriate level of specificity. Consider using any of the following billable codes with a higher level of specificity when coding for other systemic involvement of connective tissue:

  • M35.0 for Sjogren syndrome

  • Use M35.00 for Sjogren syndrome, unspecified

  • Use M35.01 for Sjogren syndrome with keratoconjunctivitis

  • Use M35.02 for Sjogren syndrome with lung involvement

  • Use M35.03 for Sjogren syndrome with myopathy

  • Use M35.04 for Sjogren syndrome with tubulo-interstitial nephropathy

  • Use M35.05 for Sjogren syndrome with inflammatory arthritis

  • Use M35.06 for Sjogren syndrome with peripheral nervous system involvement

  • Use M35.07 for Sjogren syndrome with central nervous system involvement

  • Use M35.08 for Sjogren syndrome with gastrointestinal involvement

  • Use M35.09 for Sjogren syndrome with other organ involvement

  • Use M35.0A for Sjogren syndrome with glomerular disease

  • Use M35.0B for Sjogren syndrome with vasculitis

  • Use M35.0C for Sjogren syndrome with dental involvement

  • Use M35.1 for Other overlap syndromes

  • Use M35.2 for Behcet's disease

  • Use M35.3 for Polymyalgia rheumatica

  • Use M35.4 for Diffuse (eosinophilic) fasciitis

  • Use M35.5 for Multifocal fibrosclerosis

  • Use M35.6 for Relapsing panniculitis [Weber-Christian]

  • Use M35.7 for Hypermobility syndrome

  • M35.8 for Other specified systemic involvement of connective tissue

  • Use M35.81 for Multisystem inflammatory syndrome

  • Use M35.89 for Other specified systemic involvement of connective tissue

  • Use M35.9 for Systemic involvement of connective tissue, unspecified

Code Classification

  • Diseases of the musculoskeletal system and connective tissue
    M00–M99
    • Systemic connective tissue disorders
      M30-M36
      • Other systemic involvement of connective tissue
        M35

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • reactive perforating collagenosis L87.1

Patient Education


Connective Tissue Disorders

Your connective tissue supports many different parts of your body, such as your skin, eyes, and heart. It is like a "cellular glue" that gives your body parts their shape and helps keep them strong. It also helps some of your tissues do their work. It is made of many kinds of proteins. Cartilage and fat are types of connective tissue.

Over 200 disorders that impact connective tissue. There are different types:

  • Genetic disorders, such as Ehlers-Danlos syndrome, Marfan syndrome, and osteogenesis imperfecta
  • Autoimmune disorders, such as lupus and scleroderma
  • Cancers, like some types of soft tissue sarcoma

Each disorder has its own symptoms and needs different treatment.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases


[Learn More in MedlinePlus]

Code History

  • FY 2026 - No Change, effective from 10/1/2025 through 9/30/2026
  • FY 2025 - No Change, effective from 10/1/2024 through 9/30/2025
  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.