2026 ICD-10-CM Diagnosis Code M35Other systemic involvement of connective tissue

ICD-10-CM Codes›M00–M99›M30-M36›M35

ICD-10-CM M35
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

M35 is a non-billable ICD-10-CM category code for other systemic involvement of connective tissue, so it cannot be submitted on claims. Use a more specific code from this category instead, such as M35.00, M35.01, M35.02, and M35.03.

Code Identity

ICD-10-CM Code
M35
Billable Status
No — Non-Billable Category
Code Describes
Other systemic involvement of connective tissue
Chapter
M30-M36
Systemic connective tissue disorders

Code Classification

ChapterM00–M99Diseases of the musculoskeletal system and connective tissue
SectionM30-M36Systemic connective tissue disorders
CategoryM35Other systemic involvement of connective tissue
This CodeM35Other systemic involvement of connective tissue

Specific Coding for Other systemic involvement of connective tissueOverview

Non-specific codes like M35 require more characters. Use one of these billable codes instead:

  • M35.0 for Sjogren syndrome

  • Use M35.00 for Sjogren syndrome, unspecified

  • Use M35.01 for Sjogren syndrome with keratoconjunctivitis

  • Use M35.02 for Sjogren syndrome with lung involvement

  • Use M35.03 for Sjogren syndrome with myopathy

  • Use M35.04 for Sjogren syndrome with tubulo-interstitial nephropathy

  • Use M35.05 for Sjogren syndrome with inflammatory arthritis

  • Use M35.06 for Sjogren syndrome with peripheral nervous system involvement

  • Use M35.07 for Sjogren syndrome with central nervous system involvement

  • Use M35.08 for Sjogren syndrome with gastrointestinal involvement

  • Use M35.09 for Sjogren syndrome with other organ involvement

  • Use M35.0A for Sjogren syndrome with glomerular disease

  • Use M35.0B for Sjogren syndrome with vasculitis

  • Use M35.0C for Sjogren syndrome with dental involvement

  • Use M35.1 for Other overlap syndromes

  • Use M35.2 for Behcet's disease

  • Use M35.3 for Polymyalgia rheumatica

  • Use M35.4 for Diffuse (eosinophilic) fasciitis

  • Use M35.5 for Multifocal fibrosclerosis

  • Use M35.6 for Relapsing panniculitis [Weber-Christian]

  • Use M35.7 for Hypermobility syndrome

  • M35.8 for Other specified systemic involvement of connective tissue

  • Use M35.81 for Multisystem inflammatory syndrome

  • Use M35.89 for Other specified systemic involvement of connective tissue

  • Use M35.9 for Systemic involvement of connective tissue, unspecified

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Type 1 Excludes

  • reactive perforating collagenosis L87.1

Patient EducationClinical

Connective Tissue Disorders

Your connective tissue supports many different parts of your body, such as your skin, eyes, and heart. It is like a "cellular glue" that gives your body parts their shape and helps keep them strong. It also helps some of your tissues do their work. It is made of many kinds of proteins. Cartilage and fat are types of connective tissue.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About M35Overview

Is M35 (Other systemic involvement of connective tissue) a billable code?

No. This is a category header that groups the codes for other systemic involvement of connective tissue, and headers cannot be submitted on claims. Claims for other systemic involvement of connective tissue need a more specific code from this category, such as M35.00, M35.01, and M35.02.