2027 ICD-10-CM Diagnosis Code M35Other systemic involvement of connective tissue

ICD-10-CM Codes›M00–M99›M30-M36›M35

ICD-10-CM M35
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

M35 is a non-billable ICD-10-CM category code for other systemic involvement of connective tissue, so it cannot be submitted on claims. Use a more specific code from this category instead, such as M35.00, M35.01, M35.02, and M35.03.

Code Identity

ICD-10-CM Code
M35
Billable Status
No — Non-Billable Category
Code Describes
Other systemic involvement of connective tissue
Short Description
Other systemic involvement of connective tissue
Same as the full description in the CMS dataset.
Chapter
M30-M36
Systemic connective tissue disorders

Code Classification

ChapterM00–M99Diseases of the musculoskeletal system and connective tissue
SectionM30-M36Systemic connective tissue disorders
CategoryM35Other systemic involvement of connective tissue
This CodeM35Other systemic involvement of connective tissue

Specific Coding for Other systemic involvement of connective tissueOverview

Non-specific codes like M35 require more characters. Use one of these billable codes instead:

  • M35.0 for Sjogren syndrome

  • Use M35.00 for Sjogren syndrome, unspecified

  • Use M35.01 for Sjogren syndrome with keratoconjunctivitis

  • Use M35.02 for Sjogren syndrome with lung involvement

  • Use M35.03 for Sjogren syndrome with myopathy

  • Use M35.04 for Sjogren syndrome with tubulo-interstitial nephropathy

  • Use M35.05 for Sjogren syndrome with inflammatory arthritis

  • Use M35.06 for Sjogren syndrome with peripheral nervous system involvement

  • Use M35.07 for Sjogren syndrome with central nervous system involvement

  • Use M35.08 for Sjogren syndrome with gastrointestinal involvement

  • Use M35.09 for Sjogren syndrome with other organ involvement

  • Use M35.0A for Sjogren syndrome with glomerular disease

  • Use M35.0B for Sjogren syndrome with vasculitis

  • Use M35.0C for Sjogren syndrome with dental involvement

  • Use M35.1 for Other overlap syndromes

  • Use M35.2 for Behcet's disease

  • Use M35.3 for Polymyalgia rheumatica

  • Use M35.4 for Diffuse (eosinophilic) fasciitis

  • Use M35.5 for Multifocal fibrosclerosis

  • Use M35.6 for Relapsing panniculitis [Weber-Christian]

  • Use M35.7 for Hypermobility syndrome

  • M35.8 for Other specified systemic involvement of connective tissue

  • Use M35.81 for Multisystem inflammatory syndrome

  • Use M35.89 for Other specified systemic involvement of connective tissue

  • Use M35.9 for Systemic involvement of connective tissue, unspecified

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to M35: its own notes plus those printed at block M30-M36 and Chapter 13. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From Block M30-M36 Systemic connective tissue disorders applies to 84 codes
  • autoimmune disease NOS
  • collagen (vascular) disease NOS
  • systemic autoimmune disease
  • systemic collagen (vascular) disease

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

On M35 itself
  • reactive perforating collagenosis (L87.1)
From Block M30-M36 Systemic connective tissue disorders applies to 84 codes
  • autoimmune disease, single organ or single cell-type -code to relevant condition category

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Chapter 13 (M00-M99) Diseases of the musculoskeletal system and connective tissue applies to 6,687 codes
  • arthropathic psoriasis (L40.5-)
  • certain conditions originating in the perinatal period (P04-P96)
  • certain infectious and parasitic diseases (A00-B99)
  • compartment syndrome (traumatic) (T79.A-)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Notes

General instructions on how these codes are used.

From Chapter 13 (M00-M99) Diseases of the musculoskeletal system and connective tissue applies to 6,687 codes
  • Use an external cause code following the code for the musculoskeletal condition, if applicable, to identify the cause of the musculoskeletal condition

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name M35, its category, or a range that includes it.

Excludes1 2

These codes carry an Excludes1 note naming M35: they are not reported together with it, unless the two conditions are unrelated.

  • Q87.A Loeys-Dietz syndrome
    other systemic involvement of connective tissue (M35)
  • L94 Other localized connective tissue disorders
    systemic connective tissue disorders (M30-M36) names M30-M36, which includes this code

Excludes2 4

These codes carry an Excludes2 note naming M35: its condition is not part of those codes, and both may be reported when the patient has both.

  • Chapter 9 (I00-I99) Diseases of the circulatory system
    systemic connective tissue disorders (M30-M36) names M30-M36, which includes this code
  • I77 Other disorders of arteries and arterioles
    collagen (vascular) diseases (M30-M36) names M30-M36, which includes this code
  • J82 Pulmonary eosinophilia, not elsewhere classified
    pulmonary eosinophilia due to systemic connective tissue disorders (M30-M36) names M30-M36, which includes this code
  • Chapter 12 (L00-L99) Diseases of the skin and subcutaneous tissue
    systemic connective tissue disorders (M30-M36) names M30-M36, which includes this code

Code First 1

These codes say to code first a condition named in the note, and M35 is one of the conditions named.

  • J84.170 Interstitial lung disease with progressive fibrotic phenotype in diseases classified elsewhere
    systemic connective tissue disorders (M30-M36) names M30-M36, which includes this code

Patient EducationClinical

Connective Tissue Disorders

Your connective tissue supports many different parts of your body, such as your skin, eyes, and heart. It is like a "cellular glue" that gives your body parts their shape and helps keep them strong. It also helps some of your tissues do their work. It is made of many kinds of proteins. Cartilage and fat are types of connective tissue.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About M35Overview

What is the ICD-10 code for other systemic involvement of connective tissue?

M35 is the ICD-10-CM category for other systemic involvement of connective tissue, but it is a non-billable header: claims need a more specific code from this category, listed on this page.

Is M35 (Other systemic involvement of connective tissue) a billable code?

No. This is a category header that groups the codes for other systemic involvement of connective tissue, and headers cannot be submitted on claims. Claims for other systemic involvement of connective tissue need a more specific code from this category, such as M35.00, M35.01, and M35.02.

Can M35 be reported with L87.1?

Not as a rule. The Excludes1 note on M35 lists "reactive perforating collagenosis (L87.1)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).