ICD-10-CM Code M35

Other systemic involvement of connective tissue

Version 2020 Non-Billable Code

Not Valid for Submission

M35 is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of other systemic involvement of connective tissue. The code is NOT valid for the year 2020 for the submission of HIPAA-covered transactions.

ICD-10:M35
Short Description:Other systemic involvement of connective tissue
Long Description:Other systemic involvement of connective tissue

Consider the following ICD-10 codes with a higher level of specificity:

  • M35.0 - Sicca syndrome [Sjogren]
  • M35.00 - Sicca syndrome, unspecified
  • M35.01 - Sicca syndrome with keratoconjunctivitis
  • M35.02 - Sicca syndrome with lung involvement
  • M35.03 - Sicca syndrome with myopathy
  • M35.04 - Sicca syndrome with tubulo-interstitial nephropathy
  • M35.09 - Sicca syndrome with other organ involvement
  • M35.1 - Other overlap syndromes
  • M35.2 - Behcet's disease
  • M35.3 - Polymyalgia rheumatica
  • M35.4 - Diffuse (eosinophilic) fasciitis
  • M35.5 - Multifocal fibrosclerosis
  • M35.6 - Relapsing panniculitis [Weber-Christian]
  • M35.7 - Hypermobility syndrome
  • M35.8 - Other specified systemic involvement of connective tissue
  • M35.9 - Systemic involvement of connective tissue, unspecified

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code M35:

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • reactive perforating collagenosis L87.1

Code Classification

  • Diseases of the musculoskeletal system and connective tissue (M00–M99)
    • Systemic connective tissue disorders (M30-M36)
      • Other systemic involvement of connective tissue (M35)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients


Connective Tissue Disorders

Your connective tissue supports many different parts of your body, such as your skin, eyes, and heart. It is like a "cellular glue" that gives your body parts their shape and helps keep them strong. It also helps some of your tissues do their work. It is made of many kinds of proteins. Cartilage and fat are types of connective tissue.

Over 200 disorders that impact connective tissue. There are different types:

  • Genetic disorders, such as Ehlers-Danlos syndrome, Marfan syndrome, and osteogenesis imperfecta
  • Autoimmune disorders, such as lupus and scleroderma
  • Cancers, like some types of soft tissue sarcoma

Each disorder has its own symptoms and needs different treatment.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases


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