2022 ICD-10-CM Code G12

Spinal muscular atrophy and related syndromes

Version 2021

Not Valid for Submission

ICD-10:G12
Short Description:Spinal muscular atrophy and related syndromes
Long Description:Spinal muscular atrophy and related syndromes

Code Classification

  • Diseases of the nervous system (G00–G99)
    • Systemic atrophies primarily affecting the central nervous system (G10-G14)
      • Spinal muscular atrophy and related syndromes (G12)

G12 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of spinal muscular atrophy and related syndromes. The code is not specific and is NOT valid for the year 2022 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding for Spinal muscular atrophy and related syndromes

Non-specific codes like G12 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10 codes with a higher level of specificity when coding for spinal muscular atrophy and related syndromes:

  • BILLABLE CODE - Use G12.0 for Infantile spinal muscular atrophy, type I [Werdnig-Hoffman]
  • BILLABLE CODE - Use G12.1 for Other inherited spinal muscular atrophy
  • NON-BILLABLE CODE - G12.2 for Motor neuron disease
  • BILLABLE CODE - Use G12.20 for Motor neuron disease, unspecified
  • BILLABLE CODE - Use G12.21 for Amyotrophic lateral sclerosis
  • BILLABLE CODE - Use G12.22 for Progressive bulbar palsy
  • BILLABLE CODE - Use G12.23 for Primary lateral sclerosis
  • BILLABLE CODE - Use G12.24 for Familial motor neuron disease
  • BILLABLE CODE - Use G12.25 for Progressive spinal muscle atrophy
  • BILLABLE CODE - Use G12.29 for Other motor neuron disease
  • BILLABLE CODE - Use G12.8 for Other spinal muscular atrophies and related syndromes
  • BILLABLE CODE - Use G12.9 for Spinal muscular atrophy, unspecified

Information for Patients


Spinal Muscular Atrophy

What is spinal muscular atrophy (SMA)?

Spinal muscular atrophy (SMA) is a group of genetic diseases that damages and kills motor neurons. Motor neurons are a type of nerve cell in the spinal cord and lower part of the brain. They control movement in your arms, legs, face, chest, throat, and tongue.

As the motor neurons die off, your muscles start to weaken and atrophy (waste away). The muscle damage gets worse over time and can affect speaking, walking, swallowing, and breathing.

What are the types of spinal muscular atrophy (SMA) and what are their symptoms?

There are different types of SMA. They are based on how serious the disease is and when the symptoms start:

What causes spinal muscular atrophy (SMA)?

Most types of SMA are caused by a change in the SMN1 gene. This gene is responsible for making a protein that the motor neurons need to be healthy and to function. But when part of the SMN1 gene is missing or abnormal, there isn't enough protein for the motor neurons. This causes the motor neurons to die off.

Most people have two copies of the SM1 gene - one from each parent. SMA normally only happens when both copies have the gene change. If only one copy has the change, there usually aren't any symptoms. But that gene could be passed down from parent to child.

Some of the less common types of SMA may be caused by changes in other genes.

How is spinal muscular atrophy (SMA) diagnosed?

Your health care provider may use many tools to diagnose SMA:

Parents who have a family history of SMA may want to do a prenatal test to check to see whether their baby has an SMN1 gene change. An amniocentesis or in some cases a chorionic villi sampling (CVS) is used to get the sample for testing.

In some states, genetic testing for SMA is part of newborn screening tests.

What are the treatments for spinal muscular atrophy (SMA)?

There is no cure for SMA. Treatments can help manage symptoms and prevent complications. They may include

NIH: National Institute of Neurological Disorders and Stroke


[Learn More in MedlinePlus]

Code History

  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016 (First year ICD-10-CM implemented into the HIPAA code set)