2027 ICD-10-CM Diagnosis Code F43.21Adjustment disorder with depressed mood

ICD-10-CM Codes›F01–F99›F40-F48›F43

ICD-10-CM F43.21
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

F43.21 is a billable ICD-10-CM diagnosis code for adjustment disorder with depressed mood. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 881. Coders also document this condition as adjustment disorder in remission. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Trauma- and stressor-related disorders.

F43.21 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model. It still risk-adjusts in the RxHCC Part D (V08) category 133 for payment year 2027.

Code Identity

ICD-10-CM Code
F43.21
Billable Status
Yes — Valid for Submission
Code Describes
Adjustment disorder with depressed mood
Short Description
Adjustment disorder with depressed mood
Same as the full description in the CMS dataset.
Parent Code
F43.2
Adjustment disorders

Code Classification

ChapterF01–F99Mental and behavioural disorders
SectionF40-F48Anxiety, dissociative, stress-related, somatoform and other nonpsychotic mental disorders
CategoryF43Reaction to severe stress, and adjustment disorders
This CodeF43.21Adjustment disorder with depressed mood

Medicare Risk Adjustment (HCC)Billing

F43.21 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model, but it maps to payment categories in the other CMS models shown below.

CMS-HCC V28 (Medicare Advantage Payment Model)
Not mapped
no payment category in the model that pays 100% of MA risk scores
Prior Model (CMS-HCC V24)
Not mapped under V24
this diagnosis newly risk-adjusts under the V28 model
Part D (RxHCC)
RxHCC 133 — Anxiety and Other Psychiatric Disorders
also risk-adjusts in the Part D prescription drug model (V08)

Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Adjustment disorder in remission
  • Adjustment disorder with depressed mood
  • Adjustment disorder with depressed mood in remission
  • Anticipatory grief
  • Brief depressive adjustment reaction
  • Complicated grieving
  • Grieving before death
  • Grieving process during pregnancy
  • Prolonged depressive adjustment reaction
  • Working through the pain of grief

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to F43.21: its own notes plus those printed at F43.2 and Chapter 5. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From Chapter 5 (F01-F99) Mental and behavioural disorders applies to 872 codes
  • disorders of psychological development

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From F43.2 Adjustment disorders applies to 7 codes
  • separation anxiety disorder of childhood (F93.0)
From Chapter 5 (F01-F99) Mental and behavioural disorders applies to 872 codes
  • symptoms, signs and abnormal clinical laboratory findings, not elsewhere classified (R00-R99)

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name F43.21, its category, or a range that includes it.

Excludes2 4

These codes carry an Excludes2 note naming F43.21: its condition is not part of those codes, and both may be reported when the patient has both.

  • F32 Depressive episode
    adjustment disorder (F43.2) names F43.2, which includes this code
  • F41 Other anxiety disorders
    transient adjustment reaction (F43.2) names F43.2, which includes this code
  • F94.2 Disinhibited attachment disorder of childhood
    hospitalism in children (F43.2-) names F43.2-, which includes this code
  • F93.0 Separation anxiety disorder of childhood
    nonpsychotic mental disorders (F40-F48) names F40-F48, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR MBD007
Trauma- and stressor-related disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Adjustment Disorders

    maladaptive reactions to identifiable psychosocial stressors occurring within a short time after onset of the stressor. they are manifested by either impairment in social or occupational functioning or by symptoms (depression, anxiety, etc.) that are in excess of a normal and expected reaction to the stressor.

Patient EducationClinical

Mental Disorders

Mental disorders (or mental illnesses) are conditions that affect your thinking, feeling, mood, and behavior. They may happen over a short period of time or come and go. Some can be chronic (long-lasting). They can affect your ability to relate to others and function each day..

The full article covers:

  • What are mental disorders?
  • What are some types of mental disorders?
  • What causes mental disorders?
  • Who is at risk for mental disorders?
  • How are mental disorders diagnosed?
  • What are the treatments for mental disorders?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert F43.21 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
309.0 Adjustmnt dis w depressn
Approximate The match is approximate rather than exact.
ICD-9-CM
309.1 Prolong depressive react
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About F43.21Overview

What is the ICD-10 code for adjustment disorder with depressed mood?

The ICD-10-CM code for adjustment disorder with depressed mood is F43.21 (sometimes written as F4321). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is F43.21 (Adjustment disorders) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report adjustment disorder with depressed mood on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does F43.21 group to?

When adjustment disorder with depressed mood is the principal diagnosis on an inpatient stay, it groups to MS-DRG 881 (depressive Neuroses), which carries a relative weight of 0.8963. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of F43.21?

Under the General Equivalence Mappings, adjustment disorder with depressed mood converts to ICD-9-CM 309.0 (adjustmnt dis w depressn) and 309.1 (prolong depressive react). The mapping is approximate, so confirm the match fits the documentation.

Does F43.21 risk-adjust for Medicare Advantage payment?

Not for Medicare Advantage: F43.21 maps to no category in the CMS-HCC V28 model. It still risk-adjusts in the RxHCC Part D (V08) category 133 (Anxiety and Other Psychiatric Disorders).