2026 ICD-10-CM Diagnosis Code F19.281Other psychoactive substance dependence with psychoactive substance-induced sexual dysfunction

ICD-10-CM Codes›F01–F99›F10-F19›F19

ICD-10-CM F19.281
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

F19.281 is a billable ICD-10-CM diagnosis code for other psychoactive substance dependence with psychoactive substance-induced sexual dysfunction. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 894 through 897. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified substance-related disorders.

Code Identity

ICD-10-CM Code
F19.281
Billable Status
Yes — Valid for Submission
Code Describes
Other psychoactive substance dependence with psychoactive substance-induced sexual dysfunction
Short Description
Oth psychoactive substance dependence w sexual dysfunction
Parent Code
F19.28
Other psychoactive substance dependence with other psychoactive substance-induced disorders

Code Classification

ChapterF01–F99Mental and behavioural disorders
SectionF10-F19Mental and behavioral disorders due to psychoactive substance use
CategoryF19Other psychoactive substance related disorders
This CodeF19.281Other psychoactive substance dependence with psychoactive substance-induced sexual dysfunction

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Dependence(on) (syndrome)
      • drug NEC
        • psychoactive NEC
          • with
            • sexual dysfunction
    • Disorder(of)
      • substance use (other) (unknown)
        • moderate or severe
          • with substance-induced
            • sexual dysfunction
    • Dysfunction
      • sexual (due to)
        • psychoactive substances NEC
          • in
            • dependence

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR MBD025
Other specified substance-related disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Drug Use and Addiction

Drugs are chemical substances that can change how your body and mind work. They include prescription medicines, over-the-counter medicines, alcohol, tobacco, and illegal drugs.

The full article covers:

  • What are drugs?
  • What is drug use?
  • What is drug addiction?
  • Does everyone who takes drugs become addicted?
  • Who is at risk for drug addiction?
  • What are the signs that someone has a drug problem?
  • What are the treatments for drug addiction?
  • Can drug use and addiction be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert F19.281 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
292.89 Drug mental disorder NEC
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.
ICD-9-CM
304.60 Drug depend NEC-unspec
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About F19.281Overview

Is F19.281 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other psychoactive substance dependence with psychoactive substance-induced sexual dysfunction on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does F19.281 group to?

When other psychoactive substance dependence with psychoactive substance-induced sexual dysfunction is the principal diagnosis on an inpatient stay, it groups to MS-DRG 894, 895, 896, 897, with relative weights from 0.6169 to 1.7451 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of F19.281?

Under the General Equivalence Mappings, other psychoactive substance dependence with psychoactive substance-induced sexual dysfunction converts to ICD-9-CM 292.89 (drug mental disorder NEC) and 304.60 (drug depend NEC-unspec). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.