2027 ICD-10-CM Diagnosis Code F19.221Other psychoactive substance dependence with intoxication delirium
ICD-10-CM Codes›F01–F99›F10-F19›F19
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Risk Adjusts — HCC 137
- Chronic Condition
F19.221 is a billable ICD-10-CM diagnosis code for other psychoactive substance dependence with intoxication delirium. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 894 through 897. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 463 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified substance-related disorders.
For Medicare Advantage risk adjustment, F19.221 maps to CMS-HCC Category 137 (Drug Use Disorder, Moderate/Severe, or Drug Use with Non-Psychotic Complications) under the V28 model, adding a risk factor of about 0.424 for a community, non-dual, aged beneficiary in payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
F19.221 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to F19.221: its own notes plus those printed at F19.22, F19.2, F19, and Chapter 5. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- polysubstance drug use (indiscriminate drug use)
- disorders of psychological development
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- other psychoactive substance dependence with withdrawal (F19.23-)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name F19.221, its category, or a range that includes it.
Excludes1 3
These codes carry an Excludes1 note naming F19.221: they are not reported together with it, unless the two conditions are unrelated.
- F19.1 Other psychoactive substance abuseother psychoactive substance dependence (F19.2-) names F19.2-, which includes this code
- F19.23 Other psychoactive substance dependence with withdrawalother psychoactive substance dependence with intoxication (F19.22-) names F19.22-, which includes this code
- F19.9 Other psychoactive substance use, unspecifiedother psychoactive substance dependence (F19.2-) names F19.2-, which includes this code
Excludes2 2
These codes carry an Excludes2 note naming F19.221: its condition is not part of those codes, and both may be reported when the patient has both.
- F44.0 Dissociative amnesiaalcohol-or other psychoactive substance-induced amnestic disorder (F10, F13, F19 with .26, .96) names F19, which includes this code
- T40 Poisoning by, adverse effect of and underdosing of narcotics and psychodysleptics [hallucinogens]drug dependence and related mental and behavioral disorders due to psychoactive substance use (F10.-F19.-) names F19.-, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Disorder (of) See Also: Disease;
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Delirium
Delirium is a mental state in which you are confused, disoriented, and not able to think or remember clearly. It usually starts suddenly. It is often temporary and treatable.
The full article covers:
- What is delirium?
- What causes delirium?
- Who is more likely to get delirium?
- What are the symptoms of delirium?
- How is delirium diagnosed?
- What are the treatments for delirium?
- Can delirium be prevented?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert F19.221 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About F19.221Overview
What is the ICD-10 code for other psychoactive substance dependence with intoxication delirium?
The ICD-10-CM code for other psychoactive substance dependence with intoxication delirium is F19.221 (sometimes written as F19221). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is F19.221 (Other psychoactive substance dependence with intoxication) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other psychoactive substance dependence with intoxication delirium on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does F19.221 group to?
When other psychoactive substance dependence with intoxication delirium is the principal diagnosis on an inpatient stay, it groups to MS-DRG 894, 897, 895, 896, with relative weights from 0.6272 to 1.6610 depending on complications. Higher weights mean higher Medicare reimbursement.
Is F19.221 a CC or MCC?
CMS lists F19.221 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 463 closely related codes in its exclusion list.
Can F19.221 be reported with a code from F19.23?
Not as a rule. The Excludes1 note at F19.22, which applies to F19.221, lists "other psychoactive substance dependence with withdrawal (F19.23-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What HCC is F19.221?
F19.221 (other psychoactive substance dependence with intoxication delirium) maps to CMS-HCC Category 137 (Drug Use Disorder, Moderate/Severe, or Drug Use with Non-Psychotic Complications), commonly written as HCC 137, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 55 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. It does not map to any RxHCC in the Part D prescription drug model.
Does F19.221 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, F19.221 adds a risk adjustment factor of about 0.424 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.297 to 0.502 depending on the payment segment). A more severe related category (HCC 135 and HCC 136) supersedes it when both are reported. See the full factor table on the HCC 137 category page.
