2026 ICD-10-CM Diagnosis Code F19.21Other psychoactive substance dependence, in remission

ICD-10-CM Codes›F01–F99›F10-F19›F19

ICD-10-CM F19.21
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

F19.21 is a billable ICD-10-CM diagnosis code for other psychoactive substance dependence, in remission. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 894 through 897. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Mental and substance use disorders in remission.

Code Identity

ICD-10-CM Code
F19.21
Billable Status
Yes — Valid for Submission
Code Describes
Other psychoactive substance dependence, in remission
Short Description
Other psychoactive substance dependence, in remission
Same as the full description in the CMS dataset.
Parent Code
F19.2
Other psychoactive substance dependence

Code Classification

ChapterF01–F99Mental and behavioural disorders
SectionF10-F19Mental and behavioral disorders due to psychoactive substance use
CategoryF19Other psychoactive substance related disorders
This CodeF19.21Other psychoactive substance dependence, in remission

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Combined opioid with non-opioid substance dependence
  • Combined opioid with non-opioid substance dependence in remission
  • Combined substance dependence, excluding opioid, in remission
  • Combined substance dependence, excluding opioids
  • H/O: recreational drug use
  • Hallucinogen dependence in remission
  • History of novel psychoactive substance misuse
  • History of substance dependency
  • Misused drugs in past
  • Opioid dependence in remission
  • PCP dependence
  • Phencyclidine dependence in remission
  • Phencyclidine use disorder
  • Previously injecting drug user
  • Substance dependence in remission

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Other (or unknown) substance use disorder, moderate, in early remission
  • Other (or unknown) substance use disorder, moderate, in sustained remission
  • Other (or unknown) substance use disorder, severe, in early remission
  • Other (or unknown) substance use disorder, severe, in sustained remission

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Dependence(on) (syndrome)
      • with remission
    • Dependence(on) (syndrome)
      • drug NEC
        • in remission
    • Dependence(on) (syndrome)
      • drug NEC
        • psychoactive NEC
          • in remission
    • Disorder(of)
      • substance use (other) (unknown)
        • moderate or severe
          • in remission (early) (sustained)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR MBD026
Mental and substance use disorders in remission
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Drug Use and Addiction

Drugs are chemical substances that can change how your body and mind work. They include prescription medicines, over-the-counter medicines, alcohol, tobacco, and illegal drugs.

The full article covers:

  • What are drugs?
  • What is drug use?
  • What is drug addiction?
  • Does everyone who takes drugs become addicted?
  • Who is at risk for drug addiction?
  • What are the signs that someone has a drug problem?
  • What are the treatments for drug addiction?
  • Can drug use and addiction be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert F19.21 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
292.85 Drug induced sleep disor
Approximate The match is approximate rather than exact.
ICD-9-CM
304.63 Drug depend NEC-in rem
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About F19.21Overview

Is F19.21 (Other psychoactive substance dependence) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other psychoactive substance dependence, in remission on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does F19.21 group to?

When other psychoactive substance dependence, in remission is the principal diagnosis on an inpatient stay, it groups to MS-DRG 894, 895, 896, 897, with relative weights from 0.6169 to 1.7451 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of F19.21?

Under the General Equivalence Mappings, other psychoactive substance dependence, in remission converts to ICD-9-CM 292.85 (drug induced sleep disor) and 304.63 (drug depend NEC-in rem). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.