2026 ICD-10-CM Diagnosis Code F14.21Cocaine dependence, in remission

ICD-10-CM Codes›F01–F99›F10-F19›F14

ICD-10-CM F14.21
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

F14.21 is a billable ICD-10-CM diagnosis code for cocaine dependence, in remission. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 894 through 897. Coders also document this condition as cocaine dependence. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Mental and substance use disorders in remission.

Code Identity

ICD-10-CM Code
F14.21
Billable Status
Yes — Valid for Submission
Code Describes
Cocaine dependence, in remission
Short Description
Cocaine dependence, in remission
Same as the full description in the CMS dataset.
Parent Code
F14.2
Cocaine dependence

Code Classification

ChapterF01–F99Mental and behavioural disorders
SectionF10-F19Mental and behavioral disorders due to psychoactive substance use
CategoryF14Cocaine related disorders
This CodeF14.21Cocaine dependence, in remission

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Cocaine dependence
  • Cocaine dependence in remission
  • Psychostimulant dependence in remission

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Cocaine use disorder, moderate, in early remission
  • Cocaine use disorder, moderate, in sustained remission
  • Cocaine use disorder, severe, in early remission
  • Cocaine use disorder, severe, in sustained remission

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Dependence(on) (syndrome)
      • drug NEC
        • cocaine
          • in remission
    • Disorder(of)
      • cocaine use
        • moderate or severe
          • in remission (early) (sustained)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR MBD026
Mental and substance use disorders in remission
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Cocaine

Cocaine is a very addictive drug that is made from leaves of the coca plant found in South America. It is mostly available as an illegal drug that some people use to get high. In rare cases, it is also used as a prescription drug for for anesthesia during certain surgeries.

The full article covers:

  • What is cocaine?
  • How do people use cocaine?
  • What are the short-term effects of cocaine?
  • What are the long-term effects of cocaine?
  • Can a person overdose on cocaine?
  • What are the treatments for cocaine use disorder?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert F14.21 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
304.23 Cocaine depend-remiss
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About F14.21Overview

Is F14.21 (Cocaine dependence) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report cocaine dependence, in remission on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does F14.21 group to?

When cocaine dependence, in remission is the principal diagnosis on an inpatient stay, it groups to MS-DRG 894, 895, 896, 897, with relative weights from 0.6169 to 1.7451 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of F14.21?

Under the General Equivalence Mappings, cocaine dependence, in remission converts to ICD-9-CM 304.23 (cocaine depend-remiss). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.