2026 ICD-10-CM Diagnosis Code F11.221Opioid dependence with intoxication delirium

ICD-10-CM Codes›F01–F99›F10-F19›F11

ICD-10-CM F11.221
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

F11.221 is a billable ICD-10-CM diagnosis code for opioid dependence with intoxication delirium. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 894 through 897. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Opioid-related disorders.

Code Identity

ICD-10-CM Code
F11.221
Billable Status
Yes — Valid for Submission
Code Describes
Opioid dependence with intoxication delirium
Short Description
Opioid dependence with intoxication delirium
Same as the full description in the CMS dataset.
Parent Code
F11.22
Opioid dependence with intoxication

Code Classification

ChapterF01–F99Mental and behavioural disorders
SectionF10-F19Mental and behavioral disorders due to psychoactive substance use
CategoryF11Opioid related disorders
This CodeF11.221Opioid dependence with intoxication delirium

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Delirium, delirious(acute or subacute) (not alcohol- or drug-induced)
      • due to (secondary to)
        • opioid intoxication (acute)
          • in
            • dependence
    • Dependence(on) (syndrome)
      • drug NEC
        • opioid
          • with
            • intoxication
              • with
                • delirium
    • Disorder(of)
      • opioid use
        • moderate or severe
          • with
            • opioid intoxication
              • delirium

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR MBD018
Opioid-related disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Delirium

Delirium is a mental state in which you are confused, disoriented, and not able to think or remember clearly. It usually starts suddenly. It is often temporary and treatable.

The full article covers:

  • What is delirium?
  • What causes delirium?
  • Who is more likely to get delirium?
  • What are the symptoms of delirium?
  • How is delirium diagnosed?
  • What are the treatments for delirium?
  • Can delirium be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert F11.221 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
292.81 Drug-induced delirium
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.
ICD-9-CM
304.00 Opioid dependence-unspec
ApproximateCombination The match is approximate, and more than one code can be needed to describe the source diagnosis. Confirm with contextual judgment.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About F11.221Overview

Is F11.221 (Opioid dependence with intoxication) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report opioid dependence with intoxication delirium on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does F11.221 group to?

When opioid dependence with intoxication delirium is the principal diagnosis on an inpatient stay, it groups to MS-DRG 894, 895, 896, 897, with relative weights from 0.6169 to 1.7451 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of F11.221?

Under the General Equivalence Mappings, opioid dependence with intoxication delirium converts to ICD-9-CM 292.81 (drug-induced delirium) and 304.00 (opioid dependence-unspec). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.