2026 ICD-10-CM Diagnosis Code F11.21Opioid dependence, in remission

ICD-10-CM Codes›F01–F99›F10-F19›F11

ICD-10-CM F11.21
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

F11.21 is a billable ICD-10-CM diagnosis code for opioid dependence, in remission. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 894 through 897. Coders also document this condition as combined opioid with non-opioid substance dependence. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Mental and substance use disorders in remission.

Code Identity

ICD-10-CM Code
F11.21
Billable Status
Yes — Valid for Submission
Code Describes
Opioid dependence, in remission
Short Description
Opioid dependence, in remission
Same as the full description in the CMS dataset.
Parent Code
F11.2
Opioid dependence

Code Classification

ChapterF01–F99Mental and behavioural disorders
SectionF10-F19Mental and behavioral disorders due to psychoactive substance use
CategoryF11Opioid related disorders
This CodeF11.21Opioid dependence, in remission

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Combined opioid with non-opioid substance dependence
  • Combined opioid with non-opioid substance dependence in remission
  • Opioid dependence in remission

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Opioid use disorder, moderate, in early remission
  • Opioid use disorder, moderate, in sustained remission
  • Opioid use disorder, severe, in early remission
  • Opioid use disorder, severe, in sustained remission

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Dependence(on) (syndrome)
      • drug NEC
        • opioid
          • in remission
    • Disorder(of)
      • opioid use
        • moderate or severe
          • in remission (early) (sustained)
    • Morphinism(without remission)
      • with remission
    • Morphinomania(without remission)
      • with remission

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR MBD026
Mental and substance use disorders in remission
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Opioid Dependence

    a physical and psychological reliance on opioid drugs with clinically significant distress or impairment upon abstinence.

  • Opioid Dependence with Intoxication Delirium|Opioid dependence with intoxication delirium

    evidence of opioid dependence with intoxication delirium.

  • Opioid Dependence with Intoxication with Perceptual Disturbance|Opioid dependence with intoxication with perceptual disturbance

    evidence of opioid dependence with intoxication with perceptual disturbance.

  • Opioid Dependence with Intoxication, Uncomplicated|Opioid dependence with intoxication, uncomplicated

    evidence of opioid dependence with intoxication, uncomplicated.

  • Opioid Dependence with Intoxication, Unspecified|Opioid dependence with intoxication, unspecified

    evidence of opioid dependence with intoxication.

  • Opioid Dependence with Opioid-Induced Mood Disorder|Opioid dependence with opioid-induced mood disorder

    evidence of opioid dependence with opioid-induced mood disorder.

  • Opioid Dependence with Opioid-Induced Psychotic Disorder with Delusions|Opioid dependence with opioid-induced psychotic disorder with delusions

    evidence of opioid dependence with opioid-induced psychotic disorder with delusions.

  • Opioid Dependence with Opioid-Induced Psychotic Disorder with Hallucinations|Opioid dependence with opioid-induced psychotic disorder with hallucinations

    evidence of opioid dependence with opioid-induced psychotic disorder with hallucinations.

  • Opioid Dependence with Opioid-Induced Psychotic Disorder, Unspecified|Opioid dependence with opioid-induced psychotic disorder, unspecified

    evidence of opioid dependence with opioid-induced psychotic disorder.

  • Opioid Dependence with Opioid-Induced Sexual Dysfunction|Opioid dependence with opioid-induced sexual dysfunction

    evidence of opioid dependence with opioid-induced sexual dysfunction.

  • Opioid Dependence with Opioid-Induced Sleep Disorder|Opioid dependence with opioid-induced sleep disorder

    evidence of opioid dependence with opioid-induced sleep disorder.

  • Opioid Dependence with Other Opioid-Induced Disorder|Opioid dependence with other opioid-induced disorder

    evidence of opioid dependence with other opioid-induced disorder.

  • Opioid Dependence with Unspecified Opioid-Induced Disorder|Opioid dependence with unspecified opioid-induced disorder

    evidence of opioid dependence with unspecified opioid-induced disorder.

  • Opioid Dependence with Withdrawal|Opioid dependence with withdrawal

    evidence of opioid dependence with withdrawal.

  • Opioid Dependence, in Remission|Opioid dependence, in remission

    evidence of opioid dependence, in remission.

  • Opioid Dependence, Uncomplicated|Opioid dependence, uncomplicated

    evidence of opioid dependence, uncomplicated.

Patient EducationClinical

Opioids and Opioid Use Disorder (OUD)

Opioids, sometimes called narcotics, are a type of drug. They include strong prescription pain relievers such as oxycodone, hydrocodone, fentanyl, and tramadol. The illegal drug heroin is also an opioid. Some opioids are made from the opium plant, and others are synthetic (man-made).

The full article covers:

  • What are opioids?
  • What are the side effects and risks of opioids?
  • What is opioid use disorder (OUD)?
  • How are opioid use disorder (OUD) and opioid overdose treated?
  • How can I prevent problems when taking prescription opioids?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert F11.21 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
304.03 Opioid dependence-remiss
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About F11.21Overview

Is F11.21 (Opioid dependence) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report opioid dependence, in remission on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does F11.21 group to?

When opioid dependence, in remission is the principal diagnosis on an inpatient stay, it groups to MS-DRG 894, 895, 896, 897, with relative weights from 0.6169 to 1.7451 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of F11.21?

Under the General Equivalence Mappings, opioid dependence, in remission converts to ICD-9-CM 304.03 (opioid dependence-remiss). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.