2026 ICD-10-CM Diagnosis Code C40.22Malignant neoplasm of long bones of left lower limb
ICD-10-CM Codes›C00–D49›C40-C41›C40
- Billable — Valid for Submission
- Chronic Condition
C40.22 is a billable ICD-10-CM diagnosis code for malignant neoplasm of long bones of left lower limb. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 542 through 544. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Bone cancer.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Adamantinoma of long bone
- Adamantinoma of long bone of lower limb
- Primary adamantinoma of long bone
- Primary chondrosarcoma of bone of left lower limb
- Primary chondrosarcoma of bone of lower limb
- Primary Ewing sarcoma of bone of left lower limb
- Primary malignant adamantinoma of long bone of left lower limb
- Primary malignant adamantinoma of long bone of lower limb
- Primary malignant neoplasm of bone of left lower limb
- Primary malignant neoplasm of long bone of lower limb
- Primary osteosarcoma of bone of left lower limb
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Chondromalacia Patellae
a degeneration of the articular cartilage of the patella, caused by a decrease in sulfated mucopolysaccharides in the ground substance. when accompanied by pain, it is sometimes considered part of or confused with patellofemoral pain syndrome.Patella
the flat, triangular bone situated at the anterior part of the knee.Patella Fracture
fractures of the patella.Patellar Dislocation
displacement of the patella from the femoral groove.Patellar Ligament
a band of fibrous tissue that attaches the apex of the patella to the lower part of the tubercle of the tibia. the ligament is actually the caudal continuation of the common tendon of the quadriceps femoris. the patella is embedded in that tendon. as such, the patellar ligament can be thought of as connecting the quadriceps femoris tendon to the tibia, and therefore it is sometimes called the patellar tendon.
Table of NeoplasmsClinical
Anatomical sites in the Table of Neoplasms that reference this code family.
| Site | Malig. Primary | Malig. Secondary | Ca in situ | Benign | Uncertain | Unspec. |
|---|---|---|---|---|---|---|
| bone (periosteum) › femur (any part) | C40.2 | C79.51 | – | D16.2 | – | – |
| bone (periosteum) › fibula (any part) | C40.2 | C79.51 | – | D16.2 | – | – |
| bone (periosteum) › knee | C40.2 | C79.51 | – | D16.2 | – | – |
| bone (periosteum) › leg NEC | C40.2 | C79.51 | – | D16.2 | – | – |
| bone (periosteum) › limb NEC › lower (long bones) | C40.2 | C79.51 | – | D16.2 | – | – |
| bone (periosteum) › patella | C40.2 | C79.51 | – | – | – | – |
| bone (periosteum) › tibia (any part) | C40.2 | C79.51 | – | – | – | – |
| cartilage (articular) (joint) NEC [See Also: Neoplasm, bone] › semilunar (knee) | C40.2 | C79.51 | – | D16.2 | D48.0 | D49.2 |
| femur (any part) | C40.2 | C79.5 | – | D16.2 | – | – |
| fibula (any part) | C40.2 | C79.51 | – | D16.2 | – | – |
| meniscus, knee joint (lateral) (medial) | C40.2 | C79.51 | – | D16.2 | D48.0 | D49.2 |
| patella | C40.2 | C79.51 | – | – | – | – |
| semilunar cartilage (knee) | C40.2 | C79.51 | – | D16.2 | D48.0 | D49.2 |
| tibia (any part) | C40.2 | C79.51 | – | D16.2 | – | – |
Patient EducationClinical
Bone Cancer
Cancer that starts in a bone is uncommon. Cancer that has spread to the bone from another part of the body is more common.
Read the full article at MedlinePlus
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Convert C40.22 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About C40.22Overview
Is C40.22 (Malignant neoplasm of long bones of lower limb) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report malignant neoplasm of long bones of left lower limb on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does C40.22 group to?
When malignant neoplasm of long bones of left lower limb is the principal diagnosis on an inpatient stay, it groups to MS-DRG 542, 543, 544, with relative weights from 0.7546 to 1.7665 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of C40.22?
Under the General Equivalence Mappings, malignant neoplasm of long bones of left lower limb converts to ICD-9-CM 170.7 (mal neo long bones leg). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.
