2024 ICD-10-CM Diagnosis Code T46.2X5A

Adverse effect of other antidysrhythmic drugs, initial encounter

ICD-10-CM Code:
T46.2X5A
ICD-10 Code for:
Adverse effect of other antidysrhythmic drugs, init encntr
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Not chronic
Code Navigator:

Code Classification

  • Injury, poisoning and certain other consequences of external causes
    (S00–T88)
    • Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
      (T36-T50)
      • Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system
        (T46)

T46.2X5A is a billable diagnosis code used to specify a medical diagnosis of adverse effect of other antidysrhythmic drugs, initial encounter. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

This code describes a circumstance which influences the patient's health status but not a current illness or injury. The code is unacceptable as a principal diagnosis.

T46.2X5A is an initial encounter code, includes a 7th character and should be used while the patient is receiving active treatment for a condition like adverse effect of other antidysrhythmic drugs. According to ICD-10-CM Guidelines an "initial encounter" doesn't necessarily means "initial visit". The 7th character should be used when the patient is undergoing active treatment regardless if new or different providers saw the patient over the course of a treatment. The appropriate 7th character codes should also be used even if the patient delayed seeking treatment for a condition.

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Adenosine adverse reaction
  • Adverse reaction to Cinchona alkaloid
  • Amiodarone adverse reaction
  • Amiodarone-induced corneal epithelial deposit
  • Antiarrhythmic drug adverse reaction
  • Bretylium adverse reaction
  • Cirrhosis of liver caused by amiodarone
  • Class I antiarrhythmic adverse reaction
  • Class II antiarrhythmic adverse reaction
  • Class III antiarrhythmic adverse reaction
  • Class IV antiarrhythmic adverse reaction
  • Disopyramide adverse reaction
  • Drug-induced cirrhosis of liver
  • Drug-induced corneal epithlelial deposit
  • Drug-induced disorder of cornea
  • Drug-induced lupus erythematosus
  • Drug-induced lupus erythematosus due to procainamide
  • Drug-induced pericarditis
  • Drug-induced thyroiditis
  • Esophagitis medicamentosa
  • Flecainide adverse reaction
  • Hyperthyroidism secondary to amiodarone
  • Hypothyroidism caused by amiodarone
  • Hypothyroidism caused by drug
  • Mexiletine adverse reaction
  • Moracizine adverse reaction
  • Pill esophagitis
  • Pill esophagitis due to quinidine
  • Procainamide adverse reaction
  • Procainamide-induced pericarditis
  • Propafenone adverse reaction
  • Quinidine adverse reaction
  • Quinidine toxicity by EKG
  • Thyroiditis caused by amiodarone
  • Tocainide adverse reaction

Clinical Classification

Clinical Information

  • Ajmaline

    an alkaloid found in the root of rauwolfia serpentina, among other plant sources. it is a class 1-a antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials.
  • Amiodarone

    an antianginal and class iii antiarrhythmic drug. it increases the duration of ventricular and atrial muscle action by inhibiting potassium channels and voltage-gated sodium channels. there is a resulting decrease in heart rate and in vascular resistance.
  • Aprindine

    a class ib anti-arrhythmia agent used to manage ventricular and supraventricular arrhythmias.
  • Bunaftine

    n-butyl-n-(2-(diethylamino)ethyl)-1-naphthamide. a proposed antiarrhythmic that prolongs myocardial refractory period and stabilizes cell membranes.
  • Disopyramide

    a class i anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. it also possesses some anticholinergic and local anesthetic properties.
  • Encainide

    one of the anti-arrhythmia agents, it blocks voltage-gated sodium channels and slows conduction within the his-purkinje system and myocardium.
  • Flecainide

    a potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial arrhythmias and tachycardias.
  • Lorajmine

    a monochloroacetyl derivative of ajmaline. it is a class ia antiarrhythmic agent that is rapidly hydrolyzed to ajmaline by plasma and tissue esterases.
  • Mexiletine

    antiarrhythmic agent pharmacologically similar to lidocaine. it may have some anticonvulsant properties.
  • Procainamide

    a class ia antiarrhythmic drug that is structurally-related to procaine.
  • Propafenone

    an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. it also has weak beta-blocking activity.
  • Quinidine

    an optical isomer of quinine, extracted from the bark of the chinchona tree and similar plant species. this alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. it prolongs cellular action potentials, and decreases automaticity. quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
  • Tocainide

    an antiarrhythmic agent which exerts a potential- and frequency-dependent block of sodium channels.

Coding Guidelines

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.

The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system (T46). Use the following options for the aplicable episode of care:

  • A - initial encounter
  • D - subsequent encounter
  • S - sequela

Code Edits

The Medicare Code Editor (MCE) detects and reports errors in the coding of claims data. The following ICD-10-CM Code Edits are applicable to this code:

  • Unacceptable principal diagnosis - There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Convert T46.2X5A to ICD-9-CM

  • ICD-9-CM Code: 995.29 - Adv eff med/biol NEC/NOS
    Combination Flag - Multiple codes are needed to describe the source diagnosis code. Correct coding should be done based on contextual judgment.
  • ICD-9-CM Code: E942.0 - Adv eff card rhyth regul
    Combination Flag - Multiple codes are needed to describe the source diagnosis code. Correct coding should be done based on contextual judgment.

Table of Drugs and Chemicals

The parent code T46.2X5 of the current diagnosis code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.

According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.

Substance Poisoning
Accidental
(unintentional)
Poisoning
Accidental
(self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
effect
Underdosing
Adenosine (phosphate)T46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
AjmalineT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
AmiodaroneT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
Antidysrhythmic NECT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
AprindineT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
Bretylium tosilateT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
BunaftineT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
CardiacT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
Cardiac
  »depressants
T46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
Cardiac
  »rhythm regulator
T46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
Cardiac
  »rhythm regulator
    »specified NEC
T46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
Chinidin (e)T46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
CibenzolineT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
DisopyramideT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
EncainideT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
FlecainideT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
HydroquinidineT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
LorajmineT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
LorcainideT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
MexiletineT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
Pilsicainide (hydrochloride)T46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
Prajmalium bitartrateT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
ProcainamideT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
Pronestyl (hydrochloride)T46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
PropafenoneT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
QuinagluteT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
QuinidineT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6
TocainideT46.2X1T46.2X2T46.2X3T46.2X4T46.2X5T46.2X6

Patient Education


Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

What is a drug interaction?

A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs, foods, or supplements or when taken while you have certain medical conditions. Examples include:

  • Two drugs, such as aspirin and blood thinners
  • Drugs and food, such as statins and grapefruit
  • Drugs and supplements, such as gingko and blood thinners
  • Drugs and medical conditions, such as aspirin and peptic ulcers

Interactions could cause a drug to be more or less effective, cause side effects, or change the way one or both drugs work.

What are side effects?

Side effects are unwanted, usually unpleasant, effects caused by medicines. Most are mild, such as a stomachache, dry mouth, or drowsiness, and go away after you stop taking the medicine. Others can be more serious. Sometimes a drug can interact with a disease that you have and cause a side effect. For example, if you have a heart condition, certain decongestants can cause you to have a rapid heartbeat.

What are drug allergies?

Drug allergies are another type of reaction. They can range from mild to life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is less common.

How can I stay safe when taking medicines?

When you start a new prescription or over-the-counter medicine, make sure you understand how to take it correctly. Know which other medicines, foods, and supplements you need to avoid. Always talk to your health care provider or pharmacist if you have questions about your medicines.


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.