2026 ICD-10-CM Diagnosis Code R11.16Cannabis hyperemesis syndrome
R11.16 is a billable ICD-10-CM diagnosis code for cannabis hyperemesis syndrome. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 391 through 392. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established.
Code Identity
Code Classification
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Cannabinoid hyperemesis syndrome
Code Also
- cannabis abuse F12.1
- cannabis dependence F12.2
- cannabis use, unspecified F12.92 F12.93 F12.95 F12.98 F12.99
- manifestations, such as:
- dehydration E86.0
- electrolyte imbalance (E87.8}
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
A "code also" note instructs that two codes may be required to fully describe a condition, but this note does not provide sequencing direction.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Syndrome - See Also: Disease;
- cannabinoid hyperemesis - R11.16
- cannabis hyperemesis - R11.16
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Syndrome
- cannabinoid hyperemesis
- Syndrome
- cannabis hyperemesis
Clinical InformationClinical
Postoperative Nausea and Vomiting
emesis and queasiness occurring after anesthesia.Vomiting
the forcible expulsion of the contents of the stomach through the mouth.Vomiting, Anticipatory
vomiting caused by expectation of discomfort or unpleasantness.
Code History & ChangesHistory
New Code R11.16 was added to the ICD-10-CM code set for FY 2026, effective October 1, 2025.
Replacement R11.16 replaces the following previously assigned code(s):
- R11.10 - Vomiting, unspecified
Questions About R11.16Overview
Is R11.16 (Vomiting) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report cannabis hyperemesis syndrome on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does R11.16 group to?
When cannabis hyperemesis syndrome is the principal diagnosis on an inpatient stay, it groups to MS-DRG 391, 392, with relative weights from 0.7796 to 1.2683 depending on complications. Higher weights mean higher Medicare reimbursement.
Can R11.16 be a principal diagnosis?
Use it with care. This is a symptom code, so once a definitive diagnosis explaining the cannabis hyperemesis syndrome is established, that condition takes the principal position instead.
