2026 ICD-10-CM Diagnosis Code O26.643Intrahepatic cholestasis of pregnancy, third trimester

ICD-10-CM Codes›O00-O9A›O20-O29›O26

ICD-10-CM O26.643
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

O26.643 is a billable ICD-10-CM diagnosis code for intrahepatic cholestasis of pregnancy, third trimester. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 817 through 819, 831 through 833. The code is restricted by the Medicare Code Editor to maternity cases (age 9 through 64). In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified liver disease and Other specified complications in pregnancy.

Code Identity

ICD-10-CM Code
O26.643
Billable Status
Yes — Valid for Submission
Code Describes
Intrahepatic cholestasis of pregnancy, third trimester
Short Description
Intrahepatic cholestasis of pregnancy, third trimester
Same as the full description in the CMS dataset.
Parent Code
O26.64
Intrahepatic cholestasis of pregnancy

Code Classification

ChapterO00-O9APregnancy, childbirth and the puerperium
SectionO20-O29Other maternal disorders predominantly related to pregnancy
CategoryO26Maternal care for other conditions predominantly related to pregnancy
This CodeO26.643Intrahepatic cholestasis of pregnancy, third trimester

Code EditsBilling

Medicare Code Editor checks that affect claim validity for O26.643.

Maternity diagnoses
The Medicare Code Editor detects inconsistencies in maternity cases by checking a patient's age and any diagnosis on the patient's record. The maternity code edits apply to patients age ange is 9–64 years inclusive (e.g., diabetes in pregnancy, antepartum pulmonary complication).

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR DIG019
Other specified and unspecified liver disease
Default principal diagnosis: inpatient No · outpatient No
CCSR PRG028
Other specified complications in pregnancy
Default principal diagnosis: inpatient Yes · outpatient Yes

Code History & ChangesHistory

Replacement O26.643 replaces the following previously assigned code(s):

  • O26.613 - Liver and biliary tract disord in pregnancy, third trimester
FY 2024AddedAdded to the ICD-10-CM code setEffective October 1, 2023.
FY 2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About O26.643Overview

Is O26.643 (Intrahepatic cholestasis of pregnancy) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report intrahepatic cholestasis of pregnancy, third trimester on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does O26.643 group to?

When intrahepatic cholestasis of pregnancy, third trimester is the principal diagnosis on an inpatient stay, it groups to MS-DRG 817, 818, 819, 831, 832, 833, with relative weights from 0.5229 to 1.6880 depending on complications. Higher weights mean higher Medicare reimbursement.

Who can O26.643 be reported for?

The Medicare Code Editor checks intrahepatic cholestasis of pregnancy, third trimester against patient demographics: this code is intended for maternity cases (age 9 through 64). Claims outside these limits are flagged as inconsistent.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.