2026 ICD-10-CM Diagnosis Code F15.21Other stimulant dependence, in remission

ICD-10-CM Codes›F01–F99›F10-F19›F15

ICD-10-CM F15.21
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

F15.21 is a billable ICD-10-CM diagnosis code for other stimulant dependence, in remission. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 894 through 897. Coders also document this condition as amphetamine and/or amphetamine derivative dependence. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Mental and substance use disorders in remission.

Code Identity

ICD-10-CM Code
F15.21
Billable Status
Yes — Valid for Submission
Code Describes
Other stimulant dependence, in remission
Short Description
Other stimulant dependence, in remission
Same as the full description in the CMS dataset.
Parent Code
F15.2
Other stimulant dependence

Code Classification

ChapterF01–F99Mental and behavioural disorders
SectionF10-F19Mental and behavioral disorders due to psychoactive substance use
CategoryF15Other stimulant related disorders
This CodeF15.21Other stimulant dependence, in remission

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Amphetamine and/or amphetamine derivative dependence
  • Amphetamine and/or amphetamine derivative dependence in remission
  • History of amphetamine abuse
  • History of methamphetamine abuse
  • Psychostimulant dependence in remission

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Amphetamine type substance use disorder, moderate, in early remission
  • Amphetamine type substance use disorder, moderate, in sustained remission
  • Amphetamine type substance use disorder, severe, in early remission
  • Amphetamine type substance use disorder, severe, in sustained remission
  • Other or unspecified stimulant use disorder, moderate, in early remission
  • Other or unspecified stimulant use disorder, moderate, in sustained remission
  • Other or unspecified stimulant use disorder, severe, in early remission
  • Other or unspecified stimulant use disorder, severe, in sustained remission

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Dependence(on) (syndrome)
      • drug NEC
        • stimulant NEC
          • in remission
    • Disorder(of)
      • amphetamine-type substance use
        • moderate
          • in remission (early) (sustained)
    • Disorder(of)
      • amphetamine-type substance use
        • severe
          • in remission (early) (sustained)
    • Disorder(of)
      • stimulant use (other) (unspecified)
        • moderate or severe
          • in remission (early) (sustained)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR MBD026
Mental and substance use disorders in remission
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Drug Use and Addiction

Drugs are chemical substances that can change how your body and mind work. They include prescription medicines, over-the-counter medicines, alcohol, tobacco, and illegal drugs.

The full article covers:

  • What are drugs?
  • What is drug use?
  • What is drug addiction?
  • Does everyone who takes drugs become addicted?
  • Who is at risk for drug addiction?
  • What are the signs that someone has a drug problem?
  • What are the treatments for drug addiction?
  • Can drug use and addiction be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert F15.21 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
304.43 Amphetamin depend-remiss
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About F15.21Overview

Is F15.21 (Other stimulant dependence) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other stimulant dependence, in remission on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does F15.21 group to?

When other stimulant dependence, in remission is the principal diagnosis on an inpatient stay, it groups to MS-DRG 894, 895, 896, 897, with relative weights from 0.6169 to 1.7451 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of F15.21?

Under the General Equivalence Mappings, other stimulant dependence, in remission converts to ICD-9-CM 304.43 (amphetamin depend-remiss). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.