2026 ICD-10-CM Diagnosis Code F13.21Sedative, hypnotic or anxiolytic dependence, in remission

ICD-10-CM Codes›F01–F99›F10-F19›F13

ICD-10-CM F13.21
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

F13.21 is a billable ICD-10-CM diagnosis code for sedative, hypnotic or anxiolytic dependence, in remission. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 894 through 897. Coders also document this condition as anxiolytic dependence. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Mental and substance use disorders in remission.

Code Identity

ICD-10-CM Code
F13.21
Billable Status
Yes — Valid for Submission
Code Describes
Sedative, hypnotic or anxiolytic dependence, in remission
Short Description
Sedative, hypnotic or anxiolytic dependence, in remission
Same as the full description in the CMS dataset.
Parent Code
F13.2
Sedative, hypnotic or anxiolytic-related dependence

Code Classification

ChapterF01–F99Mental and behavioural disorders
SectionF10-F19Mental and behavioral disorders due to psychoactive substance use
CategoryF13Sedative, hypnotic, or anxiolytic related disorders
This CodeF13.21Sedative, hypnotic or anxiolytic dependence, in remission

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Anxiolytic dependence
  • Anxiolytic dependence in remission
  • Hypnotic dependence
  • Hypnotic dependence in remission

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Sedative, hypnotic or anxiolytic use disorder, moderate, in early remission
  • Sedative, hypnotic or anxiolytic use disorder, moderate, in sustained remission
  • Sedative, hypnotic or anxiolytic use disorder, severe, in early remission
  • Sedative, hypnotic or anxiolytic use disorder, severe, in sustained remission

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Dependence(on) (syndrome)
      • drug NEC
        • sedative, hypnotic or anxiolytic
          • in remission
    • Disorder(of)
      • sedative, hypnotic, or anxiolytic use
        • moderate or severe
          • in remission (early) (sustained)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR MBD026
Mental and substance use disorders in remission
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Medicines

Medicines can treat diseases and improve your health. If you are like most people, you need to take medicine at some point in your life. You may need to take medicine every day, or you may only need to take medicine once in a while. Either way, you want to make sure that your medicines are safe, and that they will help you get better.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert F13.21 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
304.13 Sed,hyp,anxiolyt dep-rem
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About F13.21Overview

Is F13.21 (Sedative, hypnotic or anxiolytic-related dependence) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report sedative, hypnotic or anxiolytic dependence, in remission on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does F13.21 group to?

When sedative, hypnotic or anxiolytic dependence, in remission is the principal diagnosis on an inpatient stay, it groups to MS-DRG 894, 895, 896, 897, with relative weights from 0.6169 to 1.7451 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of F13.21?

Under the General Equivalence Mappings, sedative, hypnotic or anxiolytic dependence, in remission converts to ICD-9-CM 304.13 (sed,hyp,anxiolyt dep-rem). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.