2022 ICD-10-CM Code C92.21

Atypical chronic myeloid leukemia, BCR/ABL-negative, in remission

Version 2021

Valid for Submission

ICD-10:C92.21
Short Description:Atypical chronic myeloid leukemia, BCR/ABL-neg, in remission
Long Description:Atypical chronic myeloid leukemia, BCR/ABL-negative, in remission

Code Classification

  • Neoplasms (C00–D48)
    • Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96)
      • Myeloid leukemia (C92)

C92.21 is a billable diagnosis code used to specify a medical diagnosis of atypical chronic myeloid leukemia, bcr/abl-negative, in remission. The code C92.21 is valid during the fiscal year 2022 from October 01, 2021 through September 30, 2022 for the submission of HIPAA-covered transactions.

Convert C92.21 to ICD-9 Code

The General Equivalency Mapping (GEM) crosswalk indicates an approximate mapping between the ICD-10 code C92.21 its ICD-9 equivalent. The approximate mapping means there is not an exact match between the ICD-10 code and the ICD-9 code and the mapped code is not a precise representation of the original code.

Information for Patients


Chronic Myeloid Leukemia

What is leukemia?

Leukemia is a term for cancers of the blood cells. Leukemia starts in blood-forming tissues such as the bone marrow. Your bone marrow makes the cells which will develop into white blood cells, red blood cells, and platelets. Each type of cell has a different job:

When you have leukemia, your bone marrow makes large numbers of abnormal cells. This problem most often happens with white blood cells. These abnormal cells build up in your bone marrow and blood. They crowd out the healthy blood cells and make it hard for your cells and blood to do their work.

What is chronic myeloid leukemia (CML)?

Chronic myeloid leukemia (CML) is a type of chronic leukemia. "Chronic" means that the leukemia usually gets worse slowly. In CML, the bone marrow makes abnormal granulocytes (a type of white blood cell). These abnormal cells are also called blasts. When the abnormal cells crowd out the healthy cells, it can lead to infection, anemia, and easy bleeding. The abnormal cells can also spread outside the blood to other parts of the body.

CML usually occurs in adults during or after middle age. It is rare in children.

What causes chronic myeloid leukemia (CML)?

Most people with CML have a genetic change called the Philadelphia chromosome. It's called that because researchers in Philadelphia discovered it. People normally have 23 pairs of chromosomes in each cell. These chromosomes contain your DNA (genetic material). In CML, part of the DNA from one chromosome moves to another chromosome. It combines with some DNA there, which creates a new gene called BCR-ABL. This gene causes your bone marrow to make an abnormal protein. This protein allows the leukemia cells to grow out of control.

The Philadelphia chromosome isn't passed from parent to child. It happens during your lifetime. The cause is unknown.

Who is at risk for chronic myeloid leukemia (CML)?

It is hard to predict who will get CML. There are a few factors that could raise your risk:

What are the symptoms of chronic myeloid leukemia (CML)?

Sometimes CML does not cause symptoms. If you do have symptoms, they can include

How is chronic myeloid leukemia (CML) diagnosed?

Your health care provider may use many tools to diagnose CML:

If you are diagnosed with CML, you may have additional tests such as imaging tests to see whether the cancer has spread.

What are the phases of chronic myeloid leukemia (CML)?

CML has three phases. The phases are based on how much the CML has grown or spread:

What are the treatments for chronic myeloid leukemia (CML)?

There are several different treatments for CML:

Which treatments you get will depend on which phase you are in, your age, your overall health, and other factors. When the signs and symptoms of CML are reduced or have disappeared, it is called remission. The CML may come back after remission, and you may need more treatment.

NIH: National Cancer Institute


[Learn More in MedlinePlus]

Code History

  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016 (First year ICD-10-CM implemented into the HIPAA code set)