2025 ICD-10-CM Diagnosis Code Q70

Specific Coding Applicable to Syndactyly

Non-specific codes like Q70 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for syndactyly:

Clinical Information

• Poland Syndrome

  a syndrome which is characterized by symbrachydactyly and aplasia of the sternal head of pectoralis major.

• Syndactyly

  a congenital anomaly of the hand or foot, marked by the webbing between adjacent fingers or toes. syndactylies are classified as complete or incomplete by the degree of joining. syndactylies can also be simple or complex. simple syndactyly indicates joining of only skin or soft tissue; complex syndactyly marks joining of bony elements.

• Acrocephalosyndactyly

  a genetic disorder characterized by craniosynostosis and fusion of the fingers and toes.

• Fraser Syndrome|Cryptophthalmos-Syndactyly Syndrome

  a rare, autosomal recessive inherited disorder caused by mutations in the fras1, frem2, or grip1 genes. it is characterized by the presence of cryptophthalmos, cutaneous syndactyly, and genitourinary abnormalities.

• GJA1 wt Allele|AVSD3|CMDR|CX43|DFNB38|GJAL|Gap Junction Protein, Alpha 1, 43kDa (Connexin 43) Gene|Gap Junction Protein, Alpha 1, 43kDa wt Allele|Gap Junction Protein, Alpha-1 Gene|Gap Junction Protein, Alpha-Like Gene|HLHS1|HSS|ODDD|Oculodentodigital Dysplasia (Syndactyly Type III) Gene

  human gja1 wild-type allele is located in the vicinity of 6q22.31 and is approximately 14 kb in length. this allele, which encodes gap junction alpha-1 protein, plays a role in the modulation of the activity of gap junctions. mutation of the gene is associated with atrioventricular septal defect 3, autosomal recessive craniometaphyseal dysplasia, hypoplastic left heart syndrome 1, oculodentodigital dysplasia and syndactyly, type iii.

• GLI3 Gene|GLI-Kruppel Family Member GLI3 (Greig Cephalopolysyndactyly Syndrome) Gene|GLI3|GLI3

  this gene plays a regulatory role in limb development and is involved in sonic hedgehog signal transduction.

• GLI3 wt Allele|GCPS|GLI-Kruppel Family Member 3|GLI-Kruppel Family Member GLI3 (Greig Cephalopolysyndactyly Syndrome) wt Allele|GLI3|PAP-A|PAPA|PHS

  human gli3 wild-type allele is located in the vicinity of 7p13 and is approximately 272 kb in length. this allele, which encodes zinc finger protein gli3, plays a role in the regulation of sonic hedgehog-dependent transcription of specific genes during the development of multiple organ systems. this gene is the site of a mutation that is linked to greig cephalopolysyndactyly syndrome.

• Greig Syndrome|GCPS|Greig Cephalopolysyndactyly Syndrome|Greig Cephalosyndactyly Syndrome|Greig's Syndrome

  an autosomal dominant genetic disorder caused by mutations in the gli3 gene. it is characterized by physical abnormalities of the fingers and/or toes (extra fingers and/ or toes, fusion of the fingers and/or toes), large size head with prominent forehead and hypertelorism.

• Polysyndactyly

  a rare anatomical malformation characterized by polydactyly (extra fingers or toes) and syndactyly (webbed fingers or toes).

• Sclerosteosis|Cortical Hyperostosis with Syndactyly|Cortical Hyperostosis with Syndactyly

  an autosomal recessive form of craniotubular hyperostosis due to loss-of-function mutation(s) in the sost gene, encoding sclerostin. clinical features include tall stature, enlarged jaw and facial bones, and cranial nerve compression leading to hearing loss and facial palsy. about two-thirds of patients have syndactyly and/or nail malformations. increased intracranial pressure due to the thickened calvaria and skull base can occur.

• Syndactyly

  a congenital condition characterized by webbing between the fingers and/or toes, joining the digits together. in rare cases, the joining of the fingers or toes may involve bony fusion between the digits. common causes include down syndrome and hereditary syndactyly.

• TWIST1 Gene|TWIST1|TWIST1|Twist Homolog 1 (Acrocephalosyndactyly 3; Saethre-Chotzen Syndrome) (Drosophila) Gene

  this gene plays a role in regulation of transcription and the inhibition of apoptosis. it is also involved in the control of morphogenesis during embryonic development.

• TWIST1 wt Allele|ACS3|BPES2|BPES3|SCS|TWIST|Twist Homolog 1 (Acrocephalosyndactyly 3; Saethre-Chotzen Syndrome) (Drosophila) wt Allele

  human twist1 wild-type allele is located in the vicinity of 17p13.3 and is approximately 16 kb in length. this allele, which encodes twist-related protein 1, plays a role in the regulation of both transcription and cell lineage determination. mutations in the gene are associated with saethre-chotzen, robinow-sorauf, and baller-gerold syndromes.

• Twist-Related Protein 1|Acrocephalosyndactyly 3 Protein|Class A Basic Helix-Loop-Helix Protein 38|H-Twist|TWIST|TWIST1|TWIST1 Protein|Twist Homolog|Twist Homolog 1|Twist Related Protein 1|bHLHa38

  twist-related protein 1 (202 aa, ~21 kda) is encoded by the human twist1 gene. this protein plays a role in the negative regulation of both transcription and myogenesis.

• Type I Acrocephalosyndactyly|Acrocephalosyndactyly Type I|Apert Syndrome

  an autosomal dominant inherited type of acrocephalosyndactyly caused by mutations in the fgfr2 gene. it is characterized by early closure of the sutures between the skull bones, bulging eyes, low-set ears, fusion of the second, third, and forth fingers, and fusion of the toes.

• Type II Acrocephalopolysyndactyly|Acrocephalopolysyndactyly Type II|Acrocephalopolysyndactyly Type II|Carpenter 's Syndrome|Carpenter Syndrome|Carpenter Syndrome

  an extremely rare autosomal recessive syndrome characterized by premature closure of cranial sutures leading to cone-shaped head, fusion of the digits, and the presence of more digits than normal. it may be associated with heart defects, single horseshoe-shaped kidney, short stature, undescended testes, and mild mental retardation.

• Type III Acrocephalosyndactyly|Acrocephalosyndactyly Type III|Saethre-Chotzen Syndrome|Saethre-Chotzen Syndrome

  a rare autosomal dominant syndrome caused by mutations in the twist1 gene. it is characterized by premature closure of skull bones resulting in abnormally shaped head, high forehead, hypertelorism, and facial asymmetry. it may be associated with fusion of certain fingers or toes.

• Type V Acrocephalosyndactyly|Acrocephalosyndactyly Type V|Noack Syndrome|Pfeiffer Syndrome

  an autosomal dominant inherited type of acrocephalosyndactyly caused by mutations in the fgfr1 or fgfr2 genes. it is characterized by early closure of the sutures between the skull bones, bulging and wide-set eyes, broad thumbs, big toes, and partial syndactyly in the hands and toes.

• GLI3 wt Allele|ACLS|GCPS|GCPS-190|GLI-Kruppel Family Member 3|GLI-Kruppel Family Member GLI3 (Greig Cephalopolysyndactyly Syndrome) wt Allele|GLI3FL|PAP-A|PAPA|PAPA1|PAPB|PHS|PPDIV

  human gli3 wild-type allele is located in the vicinity of 7p13 and is approximately 272 kb in length. this allele, which encodes zinc finger protein gli3, plays a role in the regulation of sonic hedgehog-dependent transcription of specific genes during the development of multiple organ systems. this gene is the site of a mutation that is linked to greig cephalopolysyndactyly syndrome.

Patient Education

Birth Defects

What are birth defects?

A birth defect is a problem that happens while a baby is developing in the mother's body. Most birth defects happen during the first 3 months of pregnancy. One out of every 33 babies in the United States is born with a birth defect.

A birth defect may affect how the body looks, works, or both. Some birth defects like cleft lip or neural tube defects are structural problems that can be easy to see. Others, like heart disease, are found using special tests. Birth defects can range from mild to severe. How a birth defect affects a child's life depends mostly on which organ or body part is involved and how severe the defect is.

What causes birth defects?

For some birth defects, researchers know the cause. But for many birth defects, the exact cause is unknown. Researchers think that most birth defects are caused by a complex mix of factors, which can include:

• Genetics. One or more genes might have a change or mutation that prevents them from working properly. For example, this happens in Fragile X syndrome. With some defects, a gene or part of the gene might be missing.
• Chromosomal problems. In some cases, a chromosome or part of a chromosome might be missing. This is what happens in Turner syndrome. In other cases, such as with Down syndrome, the child has an extra chromosome.
• Exposures to medicines, chemicals, or other toxic substances. For example, alcohol misuse can cause fetal alcohol spectrum disorders.
• Infections during pregnancy. For example, infection with Zika virus during pregnancy can cause a serious defect in the brain.
• Lack of certain nutrients. Not getting enough folic acid before and during pregnancy is a key factor in causing neural tube defects.

Who is at risk of having a baby with birth defects?

Certain factors may increase the chances of having a baby with a birth defect, such as:

• Smoking, drinking alcohol, or taking certain "street" drugs during pregnancy
• Having certain medical conditions, such as obesity or uncontrolled diabetes, before and during pregnancy
• Taking certain medicines
• Having someone in your family with a birth defect. To learn more about your risk of having a baby with a birth defect, you can talk with a genetic counselor,
• Being an older mother, typically over the age of 34 years

How are birth defects diagnosed?

Health care providers can diagnose some birth defects during pregnancy, using prenatal testing. That's why it important to get regular prenatal care.

Other birth defects may not be found until after the baby is born. Providers may find them through newborn screening. Some defects, such as club foot, are obvious right away. Other times, the health care provider may not discover a defect until later in life, when the child has symptoms.

What are the treatments for birth defects?

Children with birth defects often need special care and treatments. Because the symptoms and problems caused by birth defects vary, the treatments also vary. Possible treatments may include surgery, medicines, assistive devices, physical therapy, and speech therapy.

Often, children with birth defects need a variety of services and may need to see several specialists. The primary health care provider can coordinate the special care that the child needs.

Can birth defects be prevented?

Not all birth defects can be prevented. But there are things you can do before and during pregnancy to increase your chance of having a healthy baby:

• Start prenatal care as soon as you think you might be pregnant, and see your health care provider regularly during pregnancy
• Get 400 micrograms (mcg) of folic acid every day. If possible, you should start taking it at least one month before you get pregnant.
• Don't drink alcohol, smoke, or use "street" drugs
• Talk to your health care provider about any medicines you are taking or thinking about taking. This includes prescription and over-the-counter medicines, as well as dietary or herbal supplements.
• Learn how to prevent infections during pregnancy
• If you have any medical conditions, try to get them under control before you get pregnant

Centers for Disease Control and Prevention

Code History

• FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
• FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
• FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
• FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
• FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
• FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
• FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
• FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
• FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.