2027 ICD-10-CM Diagnosis Code F48.1Depersonalization-derealization syndrome

ICD-10-CM Codes›F01–F99›F40-F48›F48

ICD-10-CM F48.1
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

F48.1 is a billable ICD-10-CM diagnosis code for depersonalization-derealization syndrome. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 882. Coders also document this condition as depersonalization. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Trauma- and stressor-related disorders.

For Medicare Advantage risk adjustment, F48.1 maps to CMS-HCC Category 153 (Personality Disorders; Anorexia/Bulimia Nervosa) under the V28 model, adding a risk factor of about 0.396 for a community, non-dual, aged beneficiary in payment year 2027.

Code Identity

ICD-10-CM Code
F48.1
Billable Status
Yes — Valid for Submission
Code Describes
Depersonalization-derealization syndrome
Short Description
Depersonalization-derealization syndrome
Same as the full description in the CMS dataset.
Parent Code
Other nonpsychotic mental disorders

Code Classification

ChapterF01–F99Mental and behavioural disorders
SectionF40-F48Anxiety, dissociative, stress-related, somatoform and other nonpsychotic mental disorders
CategoryF48Other nonpsychotic mental disorders
This CodeF48.1Depersonalization-derealization syndrome

Medicare Risk Adjustment (HCC)Billing

F48.1 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.

CMS-HCC V28 Category (Payment Model)
HCC 153— Personality Disorders; Anorexia/Bulimia Nervosa
Payment HCC · PY 2027 one of 35 ICD-10-CM codes in this category
Risk Adjustment Factor (RAF) Weight
+0.396
community, non-dual, aged · ranges 0.199–0.464 across segments
Hierarchy
Superseded by HCC 151 and HCC 152
a more severe related category takes the payment when both are reported
Prior Model (CMS-HCC V24)
HCC 60
V24 retired V28 pays 100% of MA risk scores since PY 2026
Other CMS Models
ESRD (V24): HCC 60
ESRD V24 weights: 0.066 dialysis, 0.000–0.225 functioning graft
Part D (RxHCC)
RxHCC 133 — Anxiety and Other Psychiatric Disorders
also risk-adjusts in the Part D prescription drug model (V08)

Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Depersonalization
  • Depersonalization disorder
  • Depersonalization-derealization syndrome
  • Derealization
  • Derealization syndrome
  • Disturbance of perception associated with conversion and dissociative phenomenon
  • Feels own body is unreal
  • Neurosis

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to F48.1: its own notes plus those printed at Chapter 5. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From Chapter 5 (F01-F99) Mental and behavioural disorders applies to 872 codes
  • disorders of psychological development

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Chapter 5 (F01-F99) Mental and behavioural disorders applies to 872 codes
  • symptoms, signs and abnormal clinical laboratory findings, not elsewhere classified (R00-R99)

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name F48.1, its category, or a range that includes it.

Excludes2 1

These codes carry an Excludes2 note naming F48.1: its condition is not part of those codes, and both may be reported when the patient has both.

  • F93.0 Separation anxiety disorder of childhood
    nonpsychotic mental disorders (F40-F48) names F40-F48, which includes this code

Index to Diseases and InjuriesGuidance

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR MBD007
Trauma- and stressor-related disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Mental Disorders

Mental disorders (or mental illnesses) are conditions that affect your thinking, feeling, mood, and behavior. They may happen over a short period of time or come and go. Some can be chronic (long-lasting). They can affect your ability to relate to others and function each day..

The full article covers:

  • What are mental disorders?
  • What are some types of mental disorders?
  • What causes mental disorders?
  • Who is at risk for mental disorders?
  • How are mental disorders diagnosed?
  • What are the treatments for mental disorders?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert F48.1 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
300.6 Depersonalization disord
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About F48.1Overview

What is the ICD-10 code for depersonalization-derealization syndrome?

The ICD-10-CM code for depersonalization-derealization syndrome is F48.1 (sometimes written as F481). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is F48.1 (Other nonpsychotic mental disorders) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report depersonalization-derealization syndrome on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does F48.1 group to?

When depersonalization-derealization syndrome is the principal diagnosis on an inpatient stay, it groups to MS-DRG 882 (neuroses Except Depressive), which carries a relative weight of 0.9953. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of F48.1?

Under the General Equivalence Mappings, depersonalization-derealization syndrome converts to ICD-9-CM 300.6 (depersonalization disord). The mapping is a direct match.

What HCC is F48.1?

F48.1 (depersonalization-derealization syndrome) maps to CMS-HCC Category 153 (Personality Disorders; Anorexia/Bulimia Nervosa), commonly written as HCC 153, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 60 under the retired V24 model. It also maps in the ESRD (V24) model. In the Part D prescription drug model it maps to RxHCC 133.

Does F48.1 risk-adjust for Medicare Advantage payment?

Yes. When documented and reported on a Medicare Advantage encounter, F48.1 adds a risk adjustment factor of about 0.396 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.199 to 0.464 depending on the payment segment). A more severe related category (HCC 151 and HCC 152) supersedes it when both are reported. See the full factor table on the HCC 153 category page.