2025 ICD-10-CM Diagnosis Code R53.82

Chronic fatigue, unspecified

ICD-10-CM Code:
R53.82
ICD-10 Code for:
Chronic fatigue, unspecified
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Chronic
Code Navigator:

R53.82 is a billable diagnosis code used to specify a medical diagnosis of chronic fatigue, unspecified. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2024 through September 30, 2025.

Unspecified diagnosis codes like R53.82 are acceptable when clinical information is unknown or not available about a particular condition. Although a more specific code is preferable, unspecified codes should be used when such codes most accurately reflect what is known about a patient's condition. Specific diagnosis codes should not be used if not supported by the patient's medical record.

According to ICD-10-CM guidelines this code should not to be used as a principal diagnosis code when a related definitive diagnosis has been established.

Code Classification

  • Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
    R00–R99
    • General symptoms and signs
      R50-R69
      • Malaise and fatigue
        R53

Approximate Synonyms

The following list of clinical terms are approximate synonyms, alternative descriptions, or common phrases that might be used by patients, healthcare providers, or medical coders to describe the same condition. These synonyms and related diagnosis terms are often used when searching for an ICD-10 code, especially when the exact medical terminology is unclear. Whether you're looking for lay terms, similar diagnosis names, or common language alternatives, this list can help guide you to the correct ICD-10 classification.

  • Chronic fatigue syndrome
  • Tired
  • Tired all the time

Clinical Classification

Clinical Classifications group individual ICD-10-CM diagnosis codes into broader, clinically meaningful categories. These categories help simplify complex data by organizing related conditions under common clinical themes.

They are especially useful for data analysis, reporting, and clinical decision-making. Even when diagnosis codes differ, similar conditions can be grouped together based on their clinical relevance. Each category is assigned a unique CCSR code that represents a specific clinical concept, often tied to a body system or medical specialty.

Malaise and fatigue

CCSR Code: SYM007

Inpatient Default: Y - Yes, default inpatient assignment for principal diagnosis or first-listed diagnosis.

Outpatient Default: Y - Yes, default outpatient assignment for principal diagnosis or first-listed diagnosis.

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • chronic fatigue syndrome G93.32
  • myalgic encephalomyelitis G93.32
  • other post infection and related fatigue syndromes G93.39
  • postviral fatigue syndrome G93.31

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Convert R53.82 to ICD-9-CM

Below are the ICD-9 codes that most closely match this ICD-10 code, based on the General Equivalence Mappings (GEMs). This ICD-10 to ICD-9 crosswalk tool is helpful for coders who need to reference legacy diagnosis codes for audits, historical claims, or approximate code comparisons.

Chronic fatigue syndrome

ICD-9-CM: 780.71

This is a direct match with no additional mapping qualifiers. The absence of a flag generally means the mapping is considered exact or precise. In other words, the ICD-10 code maps cleanly to the ICD-9 code without qualification, approximation, or needing multiple codes.

Patient Education


Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

What is myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, long-term illness that affects many body systems. Another name for it is chronic fatigue syndrome (CFS). ME/CFS can often make you unable to do your usual activities. Sometimes you may not even be able to get out of bed.

What causes myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?

Researchers don't yet know what causes ME/CFS. There may be more than one potential cause. It is also possible that two or more triggers might work together to cause the illness.

Researchers are studying many possible causes, including:

  • Infections
  • Immune system changes
  • Physical or emotional stress
  • Changes in the way cells in the body get their energy
  • Genetics; the illness can sometimes run in families

Who is more likely to develop myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?

Anyone can get ME/CFS, but it is most common in people between 40 and 60 years old. Adult women are more likely to develop it than adult men.

What are the symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?

The primary, or core, symptoms of ME/CFS are:

  • Not being able to do activities that you used to do before the illness, along with severe fatigue. The fatigue must last six months or longer, and it is not improved by rest.
  • Post-exertional malaise (PEM), which means that your symptoms get worse after any physical or mental activity.
  • Sleep problems.

Along with the primary symptoms, to be diagnosed with ME/CFS, you need to have one or both of these symptoms:

  • Problems with thinking and memory.
  • Worsening of symptoms while standing or sitting upright. This is called orthostatic intolerance. It can cause you to feel lightheaded, dizzy, weak, or faint while standing or sitting up.

Some of the other symptoms that ME/CFS can cause include:

  • Pain, including muscle pain, joint pain, and headaches
  • Sore throat
  • Tender lymph nodes (glands) in the neck or armpits
  • Digestive issues, like irritable bowel syndrome
  • Chills and night sweats
  • Allergies and sensitivities to foods, odors, chemicals, light, or noise

ME/CFS can be unpredictable. Your symptoms may come and go. They may change over time; sometimes they might get better, and other times they may get worse.

How is myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) diagnosed?

ME/CFS can be difficult to diagnose. There is no specific test for ME/CFS, and other illnesses can cause similar symptoms. Your health care provider has to rule out other diseases before making a diagnosis of ME/CFS.

Your provider will do a thorough medical exam, which will include:

  • Asking about your medical history and your family's medical history.
  • Asking about your current illness, including your symptoms. Some questions they may ask could include how often you have symptoms, how bad they are, how long they have lasted, and how they affect your life.
  • Thorough physical and mental status exams.
  • Blood, urine, or other tests to check for other illnesses which could be causing your symptoms.

Your provider may also ask you to see a specialist to check for other conditions which can cause similar symptoms.

What are the treatments for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?

There is no cure or approved treatment for ME/CFS, but you may be able to treat or manage some of your symptoms.

You, your family, and your provider should work together to decide on a plan. You should figure out which symptom causes you the most problems and try to treat that first. For example, if sleep problems affect you the most, you might first try using good sleep habits. If those do not help, you may need to take medicines or see a sleep specialist.

Strategies such as learning new ways to manage activity can also be helpful. You need to make sure that you do not "push and crash." This can happen when you feel better, do too much, and then get worse again.

When you have ME/CFS, it can be hard to help develop a treatment plan. It can also be difficult to try to take care of yourself. So it's important that you have support from family members and friends.

There are also various resources and strategies that might be helpful to you, such as:

  • Getting counseling to help you cope with the illness and its impact on your life.
  • Eating a healthy diet.
  • Nutritional supplements, if your provider suggests them.
  • Complementary therapies such as meditation, gentle massage, or relaxation therapy.

Make sure to talk to your provider before you try any new treatments. Some treatments that are promoted as cures for ME/CFS are unproven, often costly, and could be dangerous.

Centers for Disease Control and Prevention


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.