ICD-10 Diagnosis Code C91.12

Chronic lymphocytic leukemia of B-cell type in relapse

Diagnosis Code C91.12

ICD-10: C91.12
Short Description: Chronic lymphocytic leukemia of B-cell type in relapse
Long Description: Chronic lymphocytic leukemia of B-cell type in relapse
This is the 2018 version of the ICD-10-CM diagnosis code C91.12

Valid for Submission
The code C91.12 is valid for submission for HIPAA-covered transactions.

Code Classification
  • Neoplasms (C00–D48)
    • Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96)
      • Lymphoid leukemia (C91)

Information for Medical Professionals

Diagnostic Related Groups
The diagnosis code C91.12 is grouped in the following Diagnostic Related Group(s) (MS-DRG V35.0)

  • 820 - LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURE WITH MCC
  • 821 - LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURE WITH CC
  • 822 - LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURE WITHOUT CC/MCC

Convert to ICD-9
  • 204.12 - Chr lymp leuk in relapse

Information for Patients


Chronic Lymphocytic Leukemia

Also called: CLL

Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In chronic lymphocytic leukemia (CLL), there are too many lymphocytes, a type of white blood cell.

CLL is the second most common type of leukemia in adults. It often occurs during or after middle age, and is rare in children.

Usually CLL does not cause any symptoms. If you have symptoms, they may include

  • Painless swelling of the lymph nodes in the neck, underarm, stomach, or groin
  • Fatigue
  • Pain or a feeling of fullness below the ribs
  • Fever and infection
  • Weight loss

Tests that examine the blood, bone marrow, and lymph nodes diagnose CLL. Your doctor may choose to just monitor you until symptoms appear or change. Treatments include radiation therapy, chemotherapy, surgery to remove the spleen, and targeted therapy. Targeted therapy uses substances that attack cancer cells or block the growth and spread of cancer cells.

NIH: National Cancer Institute

  • After chemotherapy - discharge (Medical Encyclopedia)
  • B-cell leukemia/lymphoma panel (Medical Encyclopedia)
  • Bone marrow transplant (Medical Encyclopedia)
  • Bone marrow transplant - discharge (Medical Encyclopedia)
  • Chronic lymphocytic leukemia (CLL) (Medical Encyclopedia)
  • Understanding Chemotherapy - NIH - Easy-to-Read (National Cancer Institute)
  • What to Know about External Beam Radiation Therapy - NIH - Easy-to-Read (National Cancer Institute)

[Read More]

ICD-10 Footnotes

General Equivalence Map Definitions
The ICD-10 and ICD-9 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.

  • Approximate Flag - The approximate flag is on, indicating that the relationship between the code in the source system and the code in the target system is an approximate equivalent.
  • No Map Flag - The no map flag indicates that a code in the source system is not linked to any code in the target system.
  • Combination Flag - The combination flag indicates that more than one code in the target system is required to satisfy the full equivalent meaning of a code in the source system.

Present on Admission
The Present on Admission (POA) indicator is used for diagnosis codes included in claims involving inpatient admissions to general acute care hospitals. POA indicators must be reported to CMS on each claim to facilitate the grouping of diagnoses codes into the proper Diagnostic Related Groups (DRG). CMS publishes a listing of specific diagnosis codes that are exempt from the POA reporting requirement.

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