2024 ICD-10-CM Diagnosis Code T42.8X5
Adverse effect of antiparkinsonism drugs and other central muscle-tone depressants
- ICD-10-CM Code:
- T42.8X5
- ICD-10 Code for:
- Adverse effect of antiparkns drug/centr muscle-tone depr
- Is Billable?
- Not Valid for Submission
- Code Navigator:
T42.8X5 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of adverse effect of antiparkinsonism drugs and other central muscle-tone depressants. The code is not specific and is NOT valid for the year 2024 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.
Specific Coding Applicable to Adverse effect of antiparkns drug/centr muscle-tone depr
Non-specific codes like T42.8X5 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for adverse effect of antiparkns drug/centr muscle-tone depr:
Approximate Synonyms
The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:
- Adverse reaction to antiparkinsonism drug
- Adverse reaction to benserazide and/or levodopa
- Adverse reaction to carbidopa and/or levodopa
- Adverse reaction to central nervous system muscle-tone depressants
- Adverse reaction to chlorphenesin
- Adverse reaction to dopamine receptor agonist
- Adverse reaction to dopamine receptor agonist
- Adverse reaction to dopamine receptor agonist
- Adverse reaction to dopamine receptor agonist
- Adverse reaction to dopamine receptor agonist
- Adverse reaction to dopamine receptor agonist
- Adverse reaction to dopamine receptor agonist
- Adverse reaction to dopamine receptor agonist
- Adverse reaction to glycol
- Adverse reaction to mephenesin
- Amantadine adverse reaction
- Baclofen adverse reaction
- Benztropine adverse reaction
- Bromocriptine adverse reaction
- Cabergoline adverse reaction
- Carisoprodol adverse reaction
- Dantrolene adverse reaction
- Decarboxylase inhibitor adverse reaction
- Ergoline drug adverse reaction
- Ergoline drug adverse reaction
- Ergoline drug adverse reaction
- Ergoline drug adverse reaction
- Ergoline drug adverse reaction
- Ergot alkaloid adverse reaction
- Ergot alkaloid adverse reaction
- Ergot alkaloid adverse reaction
- Levodopa adverse reaction
- Lysuride adverse reaction
- Monoamine oxidase inhibitor adverse reaction
- On - off phenomenon
- Orphenadrine adverse reaction
- Orphenadrine citrate adverse reaction
- Orphenadrine hydrochloride adverse reaction
- Parkinsonism due to drug
- Pergolide adverse reaction
- Quinagolide adverse reaction
- Selegiline adverse reaction
Clinical Information
Amantadine
an antiviral that is used in the prophylactic or symptomatic treatment of influenza a. it is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. the mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.Baclofen
a gamma-aminobutyric acid derivative that is a specific agonist of gaba-b receptors. it is used in the treatment of muscle spasticity, especially that due to spinal cord injuries. its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.Receptors, GABA-B
a subset of gaba receptors that signal through their interaction with heterotrimeric g-proteins.Benserazide
an inhibitor of dopa decarboxylase that does not enter the central nervous system. it is often given with levodopa in the treatment of parkinsonism to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. it has no antiparkinson actions when given alone.Bromocriptine
a semisynthetic ergotamine alkaloid that is a dopamine d2 agonist. it suppresses prolactin secretion.Cabergoline
an ergoline derivative and dopamine d2-agonist that inhibits prolactin secretion. it is used in the management of hyperprolactinemia, and to suppress lactation following childbirth for medical reasons. cabergoline is also used in the management of parkinson disease.Carisoprodol
a centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. it is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (from martindale, the extra pharmacopoeia, 30th ed, p1202)Chlorphenesin
a centrally acting muscle relaxant. its mode of action is unknown. (from martindale, the extra pharmacopoeia, 30th ed, p1203)Chlorzoxazone
a centrally acting central muscle relaxant with sedative properties. it is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (from martindale, the extra pharmacopoea, 30th ed, p1202)Dantrolene
skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. it is used in spasticity and other neuromuscular abnormalities. although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.Levodopa
the naturally occurring form of dihydroxyphenylalanine and the immediate precursor of dopamine. unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. it is rapidly taken up by dopaminergic neurons and converted to dopamine. it is used for the treatment of parkinsonian disorders and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.Lisuride
an ergot derivative that acts as an agonist at dopamine d2 receptors (dopamine agonists). it may also act as an antagonist at dopamine d1 receptors, and as an agonist at some serotonin receptors (serotonin receptor agonists).Mephenesin
a centrally acting muscle relaxant with a short duration of action.Metergoline
a dopamine agonist and serotonin antagonist. it has been used similarly to bromocriptine as a dopamine agonist and also for migraine disorders therapy.Methocarbamol
a centrally acting muscle relaxant whose mode of action has not been established. it is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (from martindale, the extra pharmacopoeia, 30th ed, p1206)Pergolide
a long-acting dopamine agonist which has been used to treat parkinson disease and hyperprolactinemia but withdrawn from some markets due to potential for heart valve diseases.Piribedil
a dopamine d2 agonist. it is used in the treatment of parkinson disease, particularly for alleviation of tremor. it has also been used for circulatory disorders and in other applications as a d2 agonist.Selegiline
a selective, irreversible inhibitor of type b monoamine oxidase that is used for the treatment of newly diagnosed patients with parkinson disease, and for the treatment of depressive disorders. the compound without isomeric designation is deprenyl.Zoxazolamine
a uricosuric and muscle relaxant. zoxazolamine acts centrally as a muscle relaxant, but the mechanism of its action is not understood.
Coding Guidelines
When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug.
The appropriate 7th character is to be added to each code from block Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs (T42). Use the following options for the aplicable episode of care:
- A - initial encounter
- D - subsequent encounter
- S - sequela
Table of Drugs and Chemicals
The code is referenced in the Table of Drugs and Chemicals, this table contains a classification of drugs, industrial solvents, corrosive gases, noxious plants, pesticides, and other toxic agents.
According to ICD-10-CM coding guidelines it is advised to do not code directly from the Table of Drugs and Chemicals, instead always refer back to the Tabular List when doing the initial coding. Each substance in the table is assigned a code according to the poisoning classification and external causes of adverse effects. It is important to use as many codes as necessary to specify all reported drugs, medicinal or chemical substances. If the same diagnosis code describes the causative agent for more than one adverse reaction, poisoning, toxic effect or underdosing, utilize the code only once.
Patient Education
Drug Reactions
Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.
What is a drug interaction?
A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs, foods, or supplements or when taken while you have certain medical conditions. Examples include:
- Two drugs, such as aspirin and blood thinners
- Drugs and food, such as statins and grapefruit
- Drugs and supplements, such as gingko and blood thinners
- Drugs and medical conditions, such as aspirin and peptic ulcers
Interactions could cause a drug to be more or less effective, cause side effects, or change the way one or both drugs work.
What are side effects?
Side effects are unwanted, usually unpleasant, effects caused by medicines. Most are mild, such as a stomachache, dry mouth, or drowsiness, and go away after you stop taking the medicine. Others can be more serious. Sometimes a drug can interact with a disease that you have and cause a side effect. For example, if you have a heart condition, certain decongestants can cause you to have a rapid heartbeat.
What are drug allergies?
Drug allergies are another type of reaction. They can range from mild to life-threatening. Skin reactions, such as hives and rashes, are the most common type. Anaphylaxis, a serious allergic reaction, is less common.
How can I stay safe when taking medicines?
When you start a new prescription or over-the-counter medicine, make sure you understand how to take it correctly. Know which other medicines, foods, and supplements you need to avoid. Always talk to your health care provider or pharmacist if you have questions about your medicines.
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Code History
- FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
- FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
- FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
- FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
- FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
- FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
- FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
- FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
- FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.