2026 ICD-10-CM Diagnosis Code R76.12Nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis

ICD-10-CM CodesR00–R99R70-R79R76

ICD-10-CM R76.12
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

R76.12 is a billable ICD-10-CM diagnosis code for nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 177 through 179. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Abnormal findings without diagnosis.

Code Identity

ICD-10-CM Code
R76.12
Billable Status
Yes — Valid for Submission
Code Describes
Nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis
Short Description
Nonspec reaction to gamma intrfrn respns w/o actv tubrclosis
Parent Code
Nonspecific reaction to test for tuberculosis

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR70-R79Abnormal findings on examination of blood, without diagnosis
CategoryR76Other abnormal immunological findings in serum
This CodeR76.12Nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Nonspecific reaction to QuantiFERON-TB test (QFT) without active tuberculosis

Type 1 Excludes

  • nonspecific reaction to tuberculin skin test without active tuberculosis R76.11
  • positive tuberculin skin test R76.11

Index to Diseases and InjuriesGuidance

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Reaction
      • nonspecific
        • to
          • cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis
    • Reaction
      • nonspecific
        • to
          • QuantiFERON-TB test (QFT) without active tuberculosis

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR SYM017
Abnormal findings without diagnosis
Default principal diagnosis: inpatient Yes · outpatient Yes

Convert R76.12 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
795.52 Nonsp rea gma interferon
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About R76.12Overview

Is R76.12 (Nonspecific reaction to test for tuberculosis) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does R76.12 group to?

When nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis is the principal diagnosis on an inpatient stay, it groups to MS-DRG 177, 178, 179, with relative weights from 0.7550 to 1.5627 depending on complications. Higher weights mean higher Medicare reimbursement.

Can R76.12 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis is established, that condition takes the principal position instead.

What is the ICD-9 equivalent of R76.12?

Under the General Equivalence Mappings, nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis converts to ICD-9-CM 795.52 (nonsp rea gma interferon). The mapping is a direct match.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.