Valid for Submission
G31.81 is a billable diagnosis code used to specify a medical diagnosis of alpers disease. The code G31.81 is valid during the fiscal year 2022 from October 01, 2021 through September 30, 2022 for the submission of HIPAA-covered transactions.
The ICD-10-CM code G31.81 might also be used to specify conditions or terms like cerebral degeneration in childhood, progressive neuronal degeneration of childhood or progressive sclerosing poliodystrophy.
Tabular List of Diseases and Injuries
The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code G31.81:
Inclusion TermsInclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
- Grey-matter degeneration
Index to Diseases and Injuries
The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code G31.81 are found in the index:
- - Alpers' disease - G31.81
The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:
- Cerebral degeneration in childhood
- Progressive neuronal degeneration of childhood
- Progressive sclerosing poliodystrophy
- DIFFUSE CEREBRAL SCLEROSIS OF SCHILDER-. a rare central nervous system demyelinating condition affecting children and young adults. pathologic findings include a large sharply defined asymmetric focus of myelin destruction that may involve an entire lobe or cerebral hemisphere. the clinical course tends to be progressive and includes dementia cortical blindness cortical deafness spastic hemiplegia and pseudobulbar palsy. concentric sclerosis of balo is differentiated from diffuse cerebral sclerosis of schilder by the pathologic finding of alternating bands of destruction and preservation of myelin in concentric rings. alpers' syndrome refers to a heterogeneous group of diseases that feature progressive cerebral deterioration and liver disease. from adams et al. principles of neurology 6th ed p914; dev neurosci 1991;134 5:267 73
Convert G31.81 to ICD-9 Code
The General Equivalency Mapping (GEM) crosswalk indicates an approximate mapping between the ICD-10 code G31.81 its ICD-9 equivalent. The approximate mapping means there is not an exact match between the ICD-10 code and the ICD-9 code and the mapped code is not a precise representation of the original code.
Information for Patients
Degenerative Nerve Diseases
Degenerative nerve diseases affect many of your body's activities, such as balance, movement, talking, breathing, and heart function. Many of these diseases are genetic. Sometimes the cause is a medical condition such as alcoholism, a tumor, or a stroke. Other causes may include toxins, chemicals, and viruses. Sometimes the cause is unknown.
Degenerative nerve diseases include
- Alzheimer's disease
- Amyotrophic lateral sclerosis
- Friedreich ataxia
- Huntington's disease
- Lewy body disease
- Parkinson's disease
- Spinal muscular atrophy
Degenerative nerve diseases can be serious or life-threatening. It depends on the type. Most of them have no cure. Treatments may help improve symptoms, relieve pain, and increase mobility.
[Learn More in MedlinePlus]
Genetic Brain Disorders
A genetic brain disorder is caused by a variation or a mutation in a gene. A variation is a different form of a gene. A mutation is a change in a gene. Genetic brain disorders affect the development and function of the brain.
Some genetic brain disorders are due to random gene mutations or mutations caused by environmental exposure, such as cigarette smoke. Other disorders are inherited, which means that a mutated gene or group of genes is passed down through a family. They can also be due to a combination of both genetic changes and other outside factors.
Some examples of genetic brain disorders include
- Tay-Sachs disease
- Wilson disease
Many people with genetic brain disorders fail to produce enough of certain proteins that influence brain development and function. These brain disorders can cause serious problems that affect the nervous system. Some have treatments to control symptoms. Some are life-threatening.
[Learn More in MedlinePlus]
Alpers-Huttenlocher syndrome is one of the most severe of a group of conditions called the POLG-related disorders. The conditions in this group feature a range of similar signs and symptoms involving muscle-, nerve-, and brain-related functions. Alpers-Huttenlocher syndrome typically becomes apparent in children between ages 2 and 4. People with this condition usually have three characteristic features: recurrent seizures that do not improve with treatment (intractable epilepsy), loss of mental and movement abilities (psychomotor regression), and liver disease.
People with Alpers-Huttenlocher syndrome usually have additional signs and symptoms. Most have problems with coordination and balance (ataxia) and disturbances in nerve function (neuropathy). Neuropathy can lead to abnormal or absent reflexes (areflexia). In addition, affected individuals may develop weak muscle tone (hypotonia) that worsens until they lose the ability to control their muscles and movement. Some people with Alpers-Huttenlocher syndrome lose the ability to walk, sit, or feed themselves. Other movement-related symptoms in affected individuals can include involuntary muscle twitches (myoclonus), uncontrollable movements of the limbs (choreoathetosis), or a pattern of movement abnormalities known as parkinsonism.
Affected individuals may have other brain-related signs and symptoms. Migraine headaches, often with visual sensations or auras, are common. Additionally, people with this condition may have decreased brain function that is demonstrated as sleepiness, inability to concentrate, irritability, or loss of language skills or memory. Some people with the condition may lose their eyesight or hearing. People with Alpers-Huttenlocher syndrome can survive from a few months to more than 10 years after the condition first appears.
[Learn More in MedlinePlus]