2024 ICD-10-CM Diagnosis Code Q93.51

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

• Angelman syndrome
• Angelman syndrome due to maternal monosomy 15q11q13

Clinical Information

• Angelman Syndrome

  a syndrome characterized by multiple abnormalities, mental retardation, and movement disorders. present usually are skull and other abnormalities, frequent infantile spasms (spasms, infantile); easily provoked and prolonged paroxysms of laughter (hence "happy"); jerky puppetlike movements (hence "puppet"); continuous tongue protrusion; motor retardation; ataxia; muscle hypotonia; and a peculiar facies. it is associated with maternal deletions of chromosome 15q11-13 and other genetic abnormalities. (from am j med genet 1998 dec 4;80(4):385-90; hum mol genet 1999 jan;8(1):129-35)

• Angelman Syndrome

  a genetic syndrome characterized by mental retardation, speech impairment, microcephaly, ataxia, and seizures. the majority of cases result from deletions on the long arm of chromosome 15. a minority of cases result from mutations in the ube3a gene.

• NIPA1 Gene|NIPA1|NIPA1|Non Imprinted In Prader-Willi/Angelman Syndrome 1 Gene

  this gene may be involved in the development of the nervous system.

• NIPA1 wt Allele|FSP3|MGC102724|MGC35570|Non Imprinted In Prader-Willi/Angelman Syndrome 1 wt Allele|SPG6|Spastic Paraplegia 6 (Autosomal Dominant) Gene

  human nipa1 wild-type allele is located in the vicinity of 15q11.2 and is approximately 43 kb in length. this allele, which encodes non-imprinted in prader-willi/angelman syndrome region protein 1, may play a role in nervous system development. mutations in the gene are associated with autosomal dominant spastic paraplegia 6.

• NIPA2 Gene|NIPA2|NIPA2|Non Imprinted In Prader-Willi/Angelman Syndrome 2 Gene

  this gene may play a role in prostate cancer.

• NIPA2 wt Allele|MGC5466|Non Imprinted In Prader-Willi/Angelman Syndrome 2 wt Allele

  human nipa2 wild-type allele is located in the vicinity of 15q11.2 and is approximately 29 kb in length. this allele, which encodes non-imprinted in prader-willi/angelman syndrome region protein 2, may be involved in prostate cancer.

• Non-Imprinted In Prader-Willi/Angelman Syndrome Region Protein 1

  non-imprinted in prader-willi/angelman syndrome region protein 1 (329 aa, ~35 kda) is encoded by the human nipa1 gene. this protein may be involved in the development of the nervous system.

• Non-Imprinted In Prader-Willi/Angelman Syndrome Region Protein 2

  non-imprinted in prader-willi/angelman syndrome region protein 2 (360 aa, ~39 kda) is encoded by the human nipa2 gene. this protein may play a role in prostate cancer.

• UBE3A Gene|UBE3A|UBE3A|Ubiquitin Protein Ligase E3A (Human Papilloma Virus E6-Associated Protein, Angelman Syndrome) Gene

  this gene is involved in protein turnover.

• UBE3A wt Allele|ANCR|AS|E6-AP|E6AP|EPVE6AP|FLJ26981|HPVE6A|Ubiquitin Protein Ligase E3A (Human Papilloma Virus E6-Associated Protein, Angelman Syndrome) wt Allele

  human ube3a wild-type allele is located within 15q11-q13 and is approximately 102 kb in length. this allele, which encodes ubiquitin-protein ligase e3a, plays a role in protein turnover by targeting substrate proteins for degradation. mutations in this gene are associated with angelman syndrome.

Present on Admission (POA)

Q93.51 is exempt from POA reporting - The Present on Admission (POA) indicator is used for diagnosis codes included in claims involving inpatient admissions to general acute care hospitals. POA indicators must be reported to CMS on each claim to facilitate the grouping of diagnoses codes into the proper Diagnostic Related Groups (DRG). CMS publishes a listing of specific diagnosis codes that are exempt from the POA reporting requirement. Review other POA exempt codes here.

CMS POA Indicator Options and Definitions

POA Indicator	Reason for Code	CMS will pay the CC/MCC DRG?
Y	Diagnosis was present at time of inpatient admission.	YES
N	Diagnosis was not present at time of inpatient admission.	NO
U	Documentation insufficient to determine if the condition was present at the time of inpatient admission.	NO
W	Clinically undetermined - unable to clinically determine whether the condition was present at the time of inpatient admission.	YES
1	Unreported/Not used - Exempt from POA reporting.	NO

Replacement Code

Q9351 replaces the following previously assigned ICD-10-CM code(s):

• Q93.5 - Other deletions of part of a chromosome

Patient Education

Developmental Disabilities

Developmental disabilities are severe, long-term problems. They may be physical, such as blindness. They may affect mental ability, such as learning disabilities. Or the problem can be both physical and mental, such as Down syndrome. The problems are usually life-long, and can affect everyday living.

There are many causes of developmental disabilities, including:

• Genetic or chromosome abnormalities. These cause conditions such as Down syndrome and Rett syndrome.
• Prenatal exposure to substances. For example, drinking alcohol when pregnant can cause fetal alcohol spectrum disorders.
• Certain infections in pregnancy
• Preterm birth

Often there is no cure, but treatment can help the symptoms. Treatments include physical, speech, and occupational therapy. Special education classes and psychological counseling can also help.

NIH: National Institute of Child Health and Human Development

[Learn More in MedlinePlus]

Movement Disorders

Movement disorders are neurologic conditions that cause problems with movement, such as:

• Increased movement that can be voluntary (intentional) or involuntary (unintended)
• Decreased or slow voluntary movement

There are many different movement disorders. Some of the more common types include:

• Ataxia, the loss of muscle coordination
• Dystonia, in which involuntary contractions of your muscles cause twisting and repetitive movements. The movements can be painful.
• Huntington's disease, an inherited disease that causes nerve cells in certain parts of the brain to waste away. This includes the nerve cells that help to control voluntary movement.
• Parkinson's disease, which is disorder that slowly gets worse over time. It causes tremors, slowness of movement, and trouble walking.
• Tourette syndrome, a condition which causes people to make sudden twitches, movements, or sounds (tics)
• Tremor and essential tremor, which cause involuntary trembling or shaking movements. The movements may be in one or more parts of your body.

Causes of movement disorders include:

• Genetics
• Infections
• Medicines
• Damage to the brain, spinal cord, or peripheral nerves
• Metabolic disorders
• Stroke and vascular diseases
• Toxins

Treatment varies by disorder. Medicines can cure some disorders. Others get better when an underlying disease is treated. Often, however, there is no cure. In that case, the goal of treatment is to improve symptoms and relieve pain.

[Learn More in MedlinePlus]

Code History

• FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
• FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
• FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
• FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
• FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
• FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019