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  6. 2025 ICD-10-CM Code G65

2025 ICD-10-CM Diagnosis Code G65

Sequelae of inflammatory and toxic polyneuropathies

ICD-10-CM Code:
G65
ICD-10 Code for:
Sequelae of inflammatory and toxic polyneuropathies
Is Billable?
Not Valid for Submission
Code Navigator:

G65 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of sequelae of inflammatory and toxic polyneuropathies. The code is not specific and is NOT valid for the year 2025 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

G65 is a sequela code, includes a 7th character and should be used for complications that arise as a direct result of a condition like e of inflammatory and toxic polyneuropathies. According to ICD-10-CM Guidelines a "sequela" code should be used for chronic or residual conditions that are complications of an initial acute disease, illness or injury. The most common sequela is pain. Usually, two diagnosis codes are needed when reporting sequela. The first code describes the nature of the sequela while the second code describes the sequela or late effect.

Specific Coding Applicable to Sequelae of inflammatory and toxic polyneuropathies

Non-specific codes like G65 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10-CM codes with a higher level of specificity when coding for sequelae of inflammatory and toxic polyneuropathies:

  • Use G65.0 for Sequelae of Guillain-Barre syndrome - BILLABLE CODE

  • Use G65.1 for Sequelae of other inflammatory polyneuropathy - BILLABLE CODE

  • Use G65.2 for Sequelae of toxic polyneuropathy - BILLABLE CODE

Code Classification

  • Diseases of the nervous system
    G00–G99
    • Polyneuropathies and other disorders of the peripheral nervous system
      G60-G65
      • Sequelae of inflammatory and toxic polyneuropathies
        G65

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Code First

Code First
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.
  • condition resulting from (sequela) of inflammatory and toxic polyneuropathies

Patient Education


Peripheral Nerve Disorders

What are peripheral nerves?

Nerves are like wires that carry messages back and forth between your brain and your body. Your peripheral nerves branch off from your brain and spinal cord and connect to all parts of your body, including your muscles and organs. Peripheral nerves carry messages from your brain that control your movement, breathing, heartbeat, digestion, and more. They also carry messages from your body to your brain, so you can feel things, such as pain, heat, and cold.

What are peripheral nerve disorders?

Peripheral nerve disorders happen when one or more peripheral nerves are damaged. Damaged nerves may not carry messages correctly, or they may not work at all. As a result, you may have pain, trouble walking, or a variety of other problems, depending on which nerves are involved.

Peripheral nerve disorders are very common. There are more than 100 different types.

What causes peripheral nerve disorders?

Many things can damage nerves and lead to peripheral nerve disorders:

  • Diabetes is the most common cause of peripheral nerve disorders. Most people with diabetes will develop diabetic nerve problems.
  • Physical injury (trauma) that stretches, crushes, squeezes, cuts, or puts pressure on one or more nerves. Some examples of peripheral nerve disorders from physical injury include complex regional pain syndrome and brachial plexus injuries.
  • Health conditions, including:
    • Certain cancers and their treatment (chemotherapy and radiation therapy).
    • Infections, such as HIV and Lyme disease.
    • Problems with blood or blood vessels.
    • Autoimmune diseases, such as rheumatoid arthritis and lupus.
    • Kidney or liver disease.
  • Certain medicines.
  • Contact with certain toxic substances, such as lead or mercury.
  • Alcohol use disorder (AUD) and smoking.
  • Vitamin imbalances, especially a lack of vitamin B12.
  • Your genes, including changes in your genes or conditions that you inherit from your parents, such as Charcot-Marie-Tooth disease.

In certain cases, the cause of peripheral nerve disorder is not known.

What are the symptoms of peripheral nerve disorders?

The symptoms of peripheral nerve disorders depend on which nerves are affected, what is causing the damage, and how serious it is:

Types of nerves Possible symptoms of nerve damage
Motor nerves control your muscles and all your movement, such as walking, talking, and using your hands.
  • Weak or aching muscles
  • Problems with balance, walking, or using your arms and hands
  • Cramps or twitching muscles
  • Muscle shrinking
Sensory nerves carry messages to your brain from your senses, including touch, hot and cold, and pain.
  • Tingling, numbness, or pain often in the hands and feet
  • Not being able to feel heat, cold, or pain, such as a cut on your foot
  • Pain from even light touch
Autonomic nerves send messages to your organs to control breathing, digestion, and other body functions that happen without thinking about them.
  • A heartbeat that's too fast or too slow
  • Trouble swallowing
  • Sweating too much or too little
  • Vomiting, diarrhea, or constipation
  • Problems with urination or sexual function


Symptoms may range from mild to very strong. They may develop quickly over days or slowly over months and years. But they are rarely life-threatening.

How are peripheral nerve disorders diagnosed?

To find out if you have a peripheral nerve disorder, your provider will:

  • Ask about your medical history
  • Ask about your family health history
  • Do a physical exam
  • Order tests, which may include:
    • Blood tests
    • Genetic tests
    • Nerve tests that measure:
      • Electrical activity in your nerves and muscles
      • How well your autonomic nerves are working
    • A biopsy of nerve or skin tissue
    • CT or MRI scan to see what may be pressing on your nerves

What are the treatments for peripheral nerve disorders?

It's important to treat any conditions that are causing nerve damage. In certain cases, that will allow your nerves to heal over time.

Treatment for symptoms depends on the type of peripheral nerve disorder you have, where it is, and how severe. Treatment options include:

  • Braces or splints
  • Over-the-counter patches and skin creams
  • Prescription medicines
  • Non-drug pain management, such as electrical stimulation or relaxation therapy
  • Surgery to relieve pressure on a nerve

Can peripheral nerve disorders be prevented?

You can help prevent peripheral nerve disorders by:

  • Managing health conditions that may cause nerve damage, especially diabetes
  • Preventing falls and accidents
  • Avoiding toxic substances
  • Being careful to avoid repeated motions and body positions that press on your nerves
  • Eating a balanced diet, exercising, limiting alcohol, and not smoking

NIH: National Institute of Neurological Disorders and Stroke


[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.