Polyneuropathy in diseases classified elsewhere (G63)

The ICD-10 code G63 is used to identify polyneuropathy that occurs as a complication of other underlying diseases. This code captures multiple types of peripheral nerve damage linked to various systemic illnesses rather than standalone neuropathies.

Polyneuropathy in diseases classified elsewhere includes a broad range of nerve disorders caused by conditions such as infections (e.g., cytomegaloviral polyneuropathy, leprosy neuropathy), metabolic problems (uremic neuropathy, neuropathy due to vitamin B or folic acid deficiency), autoimmune diseases (polyneuropathy in rheumatoid arthritis, lupus erythematosus), and toxic or nutritional deficiencies (toxic polyneuropathy, neuropathy due to obesity or micronutrient deficits). The term covers symptoms affecting multiple peripheral nerves, often described in clinical practice by its synonyms like “neuropathy associated with endocrine disorder” or “polyneuropathy related to collagen vascular disease.” Medical coders searching for the ICD-10 code for these neuropathies should recognize G63 as the appropriate choice when nerve damage springs from these broader illnesses rather than primary nerve conditions.

Instructional Notations

Code First

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.

Type 1 Excludes

A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

Clinical Terms

The following clinical terms provide additional context, helping users better understand the clinical background and common associations for each diagnosis listed in this section. Including related terms alongside ICD-10-CM codes supports coders, billers, and healthcare professionals in improving accuracy, enhancing documentation, and facilitating research or patient education.

Herpesvirus 2, Gallid

The type species of the genus MARDIVIRUS in the family HERPESVIRIDAE. It is the etiologic agent of MAREK DISEASE, infecting domestic fowl and wild birds.

Neurolymphomatosis

Infiltration of the nervous system by malignant lymphoma cells.

Pellagra

A disease due to deficiency of NIACIN, a B-complex vitamin, or its precursor TRYPTOPHAN. It is characterized by scaly DERMATITIS which is often associated with DIARRHEA and DEMENTIA (the three D's).

POEMS Syndrome

A multisystemic disorder characterized by a sensorimotor polyneuropathy (POLYNEUROPATHIES), organomegaly, endocrinopathy, monoclonal gammopathy, and pigmentary skin changes. Other clinical features which may be present include EDEMA; CACHEXIA; microangiopathic glomerulopathy; pulmonary hypertension (HYPERTENSION, PULMONARY); cutaneous necrosis; THROMBOCYTOSIS; and POLYCYTHEMIA. This disorder is frequently associated with osteosclerotic myeloma. (From Adams et al., Principles of Neurology, 6th ed, p1335; Rev Med Interne 1997;18(7):553-62)